UniProt Q03111
Protein ENL (Q03111)
Protein ENL (UniProt Q03111): 43 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q03111
- Protein
- Protein ENL
- Experimental structures
- 43
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 15 · 5 records with a druggable one
Structures
44 records of Q03111 in the MolNFT archive: 43 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5J9S | ENL YEATS in complex with histone H3 acetylation at K27 | x-ray diffraction | A | SO4 | — |
| 5J9S | Enl yeats in complex with histone H3 acetylation at K27 | x-ray diffraction | A | — | — |
| 6HPW | Crystal structure of ENL (MLLT1) in complex with compound 20 | x-ray diffraction | A | GKT | — |
| 6HPW | Crystal structure of enl (MLLT1) in complex with compound 20 | x-ray diffraction | A | GKT | — |
| 6HPX | Crystal structure of ENL (MLLT1) in complex with compound 19 | x-ray diffraction | A | GKQ | — |
| 6HPX | Crystal structure of enl (MLLT1) in complex with compound 19 | x-ray diffraction | A | GKQ | — |
| 6HPY | Crystal structure of ENL (MLLT1) in complex with compound 12 | x-ray diffraction | A | SO4, GKN | — |
| 6HPY | Crystal structure of enl (MLLT1) in complex with compound 12 | x-ray diffraction | A | SO4, GKN | — |
| 6HPZ | Crystal structure of ENL (MLLT1) in complex with acetyllysine | x-ray diffraction | A | — | — |
| 6HPZ | Crystal structure of enl (MLLT1) in complex with acetyllysine | x-ray diffraction | A | — | — |
| 6HQ0 | Crystal structure of ENL (MLLT1), apo form | x-ray diffraction | A | — | — |
| 6HQ0 | Crystal structure of enl (MLLT1), apo form | x-ray diffraction | A | — | — |
| 6HT0 | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with compound 94 | x-ray diffraction | A | SO4, GQ8 | — |
| 6HT0 | Crystal structure of MLLT1 (enl) yeats domain in complexed with compound 94 | x-ray diffraction | A | SO4, GQ8 | — |
| 6HT1 | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with SGC-iMLLT (compound 92) | x-ray diffraction | A | SO4, GQ5 | — |
| 6HT1 | Crystal structure of MLLT1 (enl) yeats domain in complexed with sgc- imllt (compound 92) | x-ray diffraction | A | SO4, GQ5 | — |
| 6T1I | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 1 | x-ray diffraction | A | M7W | — |
| 6T1I | Crystal structure of MLLT1 (enl) yeats domain in complexed with piperazine-urea derivative 1 | x-ray diffraction | A | M7W | — |
| 6T1J | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 2 | x-ray diffraction | A | M7T | — |
| 6T1J | Crystal structure of MLLT1 (enl) yeats domain in complexed with piperazine-urea derivative 2 | x-ray diffraction | A | M7T | — |
| 6T1L | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 3 | x-ray diffraction | A | M7N | — |
| 6T1L | Crystal structure of MLLT1 (enl) yeats domain in complexed with piperazine-urea derivative 3 | x-ray diffraction | A | M7N | — |
| 6T1M | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 4 | x-ray diffraction | A | M8K | — |
| 6T1M | Crystal structure of MLLT1 (enl) yeats domain in complexed with benzimidazole-amide derivative 4 | x-ray diffraction | A | M8K | — |
| 6T1N | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 5 | x-ray diffraction | A | M7Z | — |
| 6T1N | Crystal structure of MLLT1 (enl) yeats domain in complexed with benzimidazole-amide derivative 5 | x-ray diffraction | A | M7Z | — |
| 6T1O | Crystal structure of MLLT1 (ENL) YEATS domain in complexed with benzimidazole-amide derivative 6 | x-ray diffraction | A | M82 | — |
| 6T1O | Crystal structure of MLLT1 (enl) yeats domain in complexed with benzimidazole-amide derivative 6 | x-ray diffraction | A | M82 | — |
| 7B0T | Crystal structure of MLLT1 YEATS domain T3 mutant in complex with benzimidazole-amide based… | x-ray diffraction | A | GKT | — |
| 7B0T | Crystal structure of MLLT1 yeats domain T3 mutant in complex with benzimidazole-amide based… | x-ray diffraction | A | GKT | — |
| 7B10 | Crystal structure of MLLT1 YEATS domain T1 mutant in complex with benzimidazole-amide based… | x-ray diffraction | A | GKT, IOD | — |
| 7B10 | Crystal structure of MLLT1 yeats domain T1 mutant in complex with benzimidazole-amide based… | x-ray diffraction | A | GKT, IOD | — |
| 7E74 | Crystal structure of ENL YEATS domain T3 mutant in complex with histone H3 acetylation at K27 | x-ray diffraction | A, B, C, D | — | 2 (best 0.80) |
| 7E74 | Crystal structure of enl yeats domain T3 mutant in complex with histone H3 acetylation at K27 | x-ray diffraction | A, B, C, D | — | — |
| 7E7A | Crystal structure of apo ENL YEATS domain T3 mutant | x-ray diffraction | A, B, C, D | — | 5 (best 0.77) |
| 7E7A | Crystal structure of apo enl yeats domain T3 mutant | x-ray diffraction | A, B, C, D | — | — |
| 7E7C | Crystal structure of ENL YEATS domain T1 mutant in complex with histone H3 acetylation at K27 | x-ray diffraction | A | IOD | — |
| 7E7C | Crystal structure of enl yeats domain T1 mutant in complex with histone H3 acetylation at K27 | x-ray diffraction | A | IOD | — |
| 7X88 | Crystal structure of ENL YEATS domain T2 mutant in complex with histone H3 acetylation at K27 | x-ray diffraction | A | — | — |
| 7X8B | Crystal structure of ENL T1 mutant YEATS domain in complex with histone H3 acetylation at K27 | x-ray diffraction | A, C | — | 3 (best 0.62) |
| 7X8F | Crystal structure of ENL T4 mutant YEATS domain in complex with histone H3 acetylation at K27 | x-ray diffraction | A, C | CL | 2 (best 0.64) |
| 7X8G | Crystal structure of ENL T1(H116P) mutant YEATS domain in complex with histone H3 acetylation at K27 | x-ray diffraction | A, C | — | 3 (best 0.64) |
| 8PJI | MLLT1 in complex with compound 10a | x-ray diffraction | A | ZJF, SO4 | — |
| Q03111 | AlphaFold monomer V2.0 prediction for protein enl (Q03111) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 8 records
- GKT · 3-iodanyl-4-methyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide · in 6 records
- IOD · Iodide ion · in 4 records
- GKN · 3-[4-[(4-~{tert}-butylphenyl) carbonylamino]phenyl]propanoic acid · in 2 records
- GKQ · ~{N}-[(3-chlorophenyl)methyl]-1-(2-pyrrolidin-1-ylethyl)benzimidazole-5-carboxamide · in 2 records
- GQ5 · 1-methyl-~{N}-[2-[[(2~{S})-2-methylpyrrolidin-1-yl]methyl]-3~{H}-benzimidazol-5-yl]indazole-5-carboxamide · in 2 records
- GQ8 · 1-cyclopropyl-~{N}-[2-[[(2~{S})-2-methylpyrrolidin-1-yl]methyl]-3~{H}-benzimidazol-5-yl]indazole-5-carboxamide · in 2 records
- M7N · ~{N}-[[4-(diethylaminomethyl)phenyl]methyl]-4-pyrimidin-2-yl-piperazine-1-carboxamide · in 2 records
- M7T · ~{N}-[[4-(pyrrolidin-1-ylmethyl)phenyl]methyl]-4-thiophen-2-ylcarbonyl-piperazine-1-carboxamide · in 2 records
- M7W · 4-(4-ethanoylphenyl)-~{N}-[(6-methoxypyridin-3-yl) methyl]piperazine-1-carboxamide · in 2 records
- M7Z · 4-chloranyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide · in 2 records
- M82 · 4-iodanyl-~{N}-[2-(piperidin-1-ylmethyl)-3~{H}-benzimidazol-5-yl]benzamide · in 2 records
- M8K · 4-cyano-~{N}-[2-(piperidin-1-ylmethyl)-1~{H}-benzimidazol-5-yl]benzamide · in 2 records
- CL · Chloride ion · in 1 record
- ZJF · ~{N}-cyclopentyl-1-(3-hydroxyphenyl)imidazole-4-carboxamide · in 1 record
Experiment against prediction
- 8PJI chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.47 Å
- 6HT0 chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.51 Å
- 6HT0 chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.51 Å
- 6HQ0 chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.50 Å
- 6HQ0 chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.50 Å
- 6T1L chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.53 Å
- 6T1L chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.53 Å
- 6HT1 chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.55 Å
- 6HT1 chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.55 Å
- 7B0T chain A against the predicted model Q03111: TM-score 0.99, RMSD 0.57 Å
Elsewhere
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