MolNFT v1 · #177090 · protein
Crystal structure of enl yeats domain T3 mutant in complex with histone H3 acetylation at K27
7E74 · Protein enl: “Crystal structure of enl yeats domain T3 mutant in complex with histone H3 acetylation at K27”. X-ray diffraction, 2 pockets (best druggability 0.80). MolNFT v1 #177090 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7E74
- Type
- protein
- Length
- 562 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein enl; Ala-ala-arg-aly
- UniProt
- Q03111
- Pockets
- 2 · best druggability 0.80
Structure
x-ray diffraction · 5 distinct chains · 8% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Protein enl | protein | 137 | 9% helix, 52% strand | Q03111 |
| B | Protein enl | protein | 138 | 9% helix, 52% strand | Q03111 |
| E, F | Ala-ala-arg-aly | protein | 4 | 0% helix, 0% strand | — |
| G | Ala-ala-arg-aly | protein | 2 | 0% helix, 0% strand | — |
| H | Ala-ala-arg-aly | protein | 3 | 0% helix, 33% strand | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1067 | 0.80 | 0.81 | 104 | empty |
| 2 | 1091 | 0.79 | 0.81 | 93 | empty |
Interfaces
16 interfaces between chains.
- B–D · 578 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 556 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 505 Ų buried · 6 hydrogen bonds · protein-protein
- A–E · 394 Ų buried · 9 hydrogen bonds · protein-protein
- B–H · 377 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (acetylation).
Compared structures
- 7E74 · Crystal structure of ENL YEATS domain T3 mutant in complex with histone H3 acetylation at… · the same entry in another collection · chain H against H, TM-score 1.00
- Q03111 · AlphaFold monomer V2.0 prediction for protein enl (Q03111) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03111
- Elsewhere: RCSB PDB 7E74 · PDBe 7E74 · UniProt Q03111
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