UniProt P78363
Retinal-specific phospholipid-transporting ATPase ABCA4 (P78363)
Retinal-specific phospholipid-transporting ATPase ABCA4 (UniProt P78363), EC 7.6.2.1: 15 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 159 pockets. Binding sites, druggability and experiment…
- UniProt
- P78363
- Protein
- Retinal-specific phospholipid-transporting ATPase ABCA4
- EC
- 7.6.2.1
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 159 · 8 records with a druggable one
Structures
16 records of P78363 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7E7I | Cryo-EM structure of human ABCA4 in the apo state | electron microscopy | A | NAG, BMA, 3PE | 20 (best 0.82) |
| 7E7I | Cryo-EM structure of human ABCA4 in the apo state | electron microscopy | A | NAG, BMA, 3PE | — |
| 7E7O | Cryo-EM structure of human ABCA4 in NRPE-bound state | electron microscopy | A | NAG, BMA, 3PE, HZL | 20 (best 0.82) |
| 7E7O | Cryo-EM structure of human ABCA4 in nrpe-bound state | electron microscopy | A | NAG, 3PE, HZL | — |
| 7E7Q | Cryo-EM structure of human ABCA4 in ATP-bound state | electron microscopy | A | NAG, BMA, ATP, MG | 20 (best 0.85) |
| 7E7Q | Cryo-EM structure of human ABCA4 in ATP-bound state | electron microscopy | A | NAG, ATP, MG | — |
| 7LKP | Structure of ATP-free human ABCA4 | electron microscopy | A | NAG, CLR, POV, AJP | 20 (best 0.84) |
| 7LKP | Structure of ATP-free human ABCA4 | electron microscopy | A | NAG, CLR, POV, AJP | — |
| 7LKZ | Structure of ATP-bound human ABCA4 | electron microscopy | A | NAG, 6OU, POV, MG, ATP | 20 (best 0.85) |
| 7LKZ | Structure of ATP-bound human ABCA4 | electron microscopy | A | NAG, 6OU, POV, MG, ATP | — |
| 7M1P | Human ABCA4 structure in the unbound state | electron microscopy | A | NAG, BMA | 19 (best 0.85) |
| 7M1P | Human ABCA4 structure in the unbound state | electron microscopy | A | NAG, BMA | — |
| 7M1Q | Human ABCA4 structure in complex with N-ret-PE | electron microscopy | A | NAG, BMA, HZL, MG | 20 (best 0.79) |
| 7M1Q | Human ABCA4 structure in complex with N-ret-pe | electron microscopy | A | NAG, BMA, HZL, MG | — |
| 8F5B | Human ABCA4 structure in complex with AMP-PNP | electron microscopy | A | NAG, MG, ANP | 20 (best 0.84) |
| P78363 | AlphaFold monomer V2.0 prediction for retinal-specific phospholipid- transporting ATPase ABCA4… | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 15 records
- BMA · beta-D-mannopyranose · in 8 records
- MG · Magnesium ion · in 7 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 4 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- HZL · [(2S)-3-[2-[(E)-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenylidene]amino]ethoxy-oxidanyl-phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxy-propyl] (Z)-octadec-9-enoate · in 4 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 2 records
- AJP · Digitonin · in 2 records
- CLR · Cholesterol · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
Experiment against prediction
- 7LKP chain A against the predicted model P78363: TM-score 0.96, RMSD 2.86 Å
- 7LKP chain A against the predicted model P78363: TM-score 0.96, RMSD 2.86 Å
- 7M1P chain A against the predicted model P78363: TM-score 0.95, RMSD 3.31 Å
- 7M1P chain A against the predicted model P78363: TM-score 0.95, RMSD 3.31 Å
- 7M1Q chain A against the predicted model P78363: TM-score 0.94, RMSD 3.45 Å
- 7M1Q chain A against the predicted model P78363: TM-score 0.94, RMSD 3.45 Å
- 7E7O chain A against the predicted model P78363: TM-score 0.94, RMSD 3.82 Å
- 7E7O chain A against the predicted model P78363: TM-score 0.94, RMSD 3.82 Å
- 7E7I chain A against the predicted model P78363: TM-score 0.93, RMSD 3.82 Å
- 7E7I chain A against the predicted model P78363: TM-score 0.93, RMSD 3.82 Å
Elsewhere
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