MolNFT v1 · #177108 · protein
Cryo-EM structure of human ABCA4 in ATP-bound state
7E7Q · Retinal-specific phospholipid-transporting ATPase ABCA4: “Cryo-EM structure of human ABCA4 in ATP-bound state”. Electron microscopy, 4 ligands (ATP, NAG, BMA), 20 pockets (best druggability 0.85). MolNFT v1 #177108 on GenesisL1: 3D…
- PDB
- 7E7Q
- Type
- protein
- Length
- 1,958 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinal-specific phospholipid-transporting ATPase ABCA4
- EC
- 7.6.2.1
- UniProt
- P78363
- Ligands
- ATP, NAG, BMA, MG
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 44% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinal-specific phospholipid-transporting ATPase ABCA4 (EC 7.6.2.1) | protein | 1958 | 44% helix, 9% strand | P78363 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 11 copies · chains A
- BMA · beta-D-mannopyranose · sugar · 6 copies · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 764 | 0.85 | 0.88 | 58 | empty |
| 2 | 862 | 0.81 | 0.84 | 83 | empty |
| 3 | 580 | 0.81 | 0.86 | 50 | empty |
| 4 | 839 | 0.79 | 0.82 | 91 | ATP, MG |
| 5 | 1111 | 0.75 | 0.77 | 88 | empty |
Modifications
Observed in the structure: 9 glycan, 6 disulfide (N-glycosylation, disulfide).
Compared structures
- 7E7Q · Cryo-EM structure of human ABCA4 in ATP-bound state · the same entry in another collection · chain A against A, TM-score 1.00
- P78363 · AlphaFold monomer V2.0 prediction for retinal-specific phospholipid- transporting ATPase… · a predicted model of the same protein · chain A against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78363
- Elsewhere: RCSB PDB 7E7Q · PDBe 7E7Q · UniProt P78363
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.