HZL · [(2S)-3-[2-[(E)-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenylidene]amino]ethoxy-oxidanyl-phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxy-propyl] (Z)-octadec-9-enoate

Binding sites

HZL in 4 structures; the first of them:

• 7E7O · Cryo-EM structure of human ABCA4 in NRPE-bound state · HZL A2311 · binds LEU42, TRP339, TYR340, TYR345, PHE348, ARG587, TYR588, ILE649 and 12 more
• 7M1Q · Human ABCA4 structure in complex with N-ret-PE · HZL A2304 · binds TRP41, LEU42, ALA45, ASN46, TRP339, TYR340, GLU341, TYR345 and 16 more
• 7E7O · Cryo-EM structure of human ABCA4 in nrpe-bound state · HZL A2311 · binds TYR340, TYR345, ARG587, TYR588, ILE649, ILE650, ARG653, ILE657 and 4 more
• 7M1Q · Human ABCA4 structure in complex with N-ret-pe · HZL A2304 · binds LEU42, ASN46, TYR340, TYR345, ARG587, TYR588, ILE649, ARG653 and 5 more

Residues it binds most

LEU 4, TYR 4, PHE 4, ILE 4, ARG 4, SER 4, VAL 2, TRP 2, ASN 2, ALA 1 (residue and the binding sites it lines).

Found with

• BMA · beta-D-mannopyranose
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine
• MG · Magnesium ion
• MAN · alpha-D-mannopyranose