MolNFT v1 · #181667 · protein

Human ABCA4 structure in the unbound state

7M1P · Retinal-specific phospholipid-transporting ATPase ABCA4: “Human ABCA4 structure in the unbound state”. Electron microscopy, 3 ligands (NAG, BMA, MAN), 19 pockets (best druggability 0.85). MolNFT v1 #181667 on GenesisL1: 3D…

PDB: 7M1P
Type: protein
Length: 1,938 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Retinal-specific phospholipid-transporting ATPase ABCA4
EC: 7.6.2.1
UniProt: P78363
Ligands: NAG, BMA, MAN
Pockets: 19 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 44% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Retinal-specific phospholipid-transporting ATPase ABCA4 (EC 7.6.2.1)	protein	1938	44% helix, 8% strand	P78363

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A
BMA · beta-D-mannopyranose · sugar · 2 copies · chains A
MAN · alpha-D-mannopyranose · sugar · 2 copies

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1012	0.85	0.85	123	empty
2	1068	0.84	0.85	132	empty
3	1073	0.82	0.83	152	empty
4	766	0.72	0.77	71	empty
5	430	0.71	0.82	71	empty

Modifications

Observed in the structure: 6 glycan, 5 disulfide (N-glycosylation, disulfide).

Compared structures

7M1P · Human ABCA4 structure in the unbound state · the same entry in another collection · chain A against A, TM-score 1.00
P78363 · AlphaFold monomer V2.0 prediction for retinal-specific phospholipid- transporting ATPase… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P78363
Elsewhere: RCSB PDB 7M1P · PDBe 7M1P · UniProt P78363

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