UniProt P78356
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (P78356)
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (UniProt P78356), EC 2.7.1.149: 45 experimental structures on GenesisL1, 9 ligands bound, 25 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P78356
- Protein
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
- EC
- 2.7.1.149
- Experimental structures
- 45
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 25 · 3 records with a druggable one
Structures
45 records of P78356 in the MolNFT archive: 45 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BO1 | Phosphatidylinositol phosphate kinase type II beta | x-ray diffraction | A, B | — | — |
| 1BO1 | Phosphatidylinositol phosphate kinase type II beta | x-ray diffraction | A, B | — | — |
| 3WZZ | Crystal structure of PIP4KIIBETA | x-ray diffraction | A, B | — | — |
| 3WZZ | Crystal structure of PIP4KIIBETA | x-ray diffraction | A, B | — | — |
| 3X01 | Crystal structure of PIP4KIIBETA complex with AMP | x-ray diffraction | A, B | — | — |
| 3X01 | Crystal structure of PIP4KIIBETA complex with AMP | x-ray diffraction | A, B | — | — |
| 3X02 | Crystal structure of PIP4KIIBETA complex with GMP | x-ray diffraction | A, B | — | — |
| 3X02 | Crystal structure of PIP4KIIBETA complex with gmp | x-ray diffraction | A, B | — | — |
| 3X03 | Crystal structure of PIP4KIIBETA complex with AMPPNP | x-ray diffraction | A, B | — | — |
| 3X03 | Crystal structure of PIP4KIIBETA complex with amppnp | x-ray diffraction | A, B | — | — |
| 3X04 | Crystal structure of PIP4KIIBETA complex with GMPPNP | x-ray diffraction | A, B | — | — |
| 3X04 | Crystal structure of PIP4KIIBETA complex with gmppnp | x-ray diffraction | A, B | — | — |
| 3X05 | Crystal structure of PIP4KIIBETA T201M complex with AMP | x-ray diffraction | A, B | — | — |
| 3X05 | Crystal structure of PIP4KIIBETA T201M complex with AMP | x-ray diffraction | A, B | — | — |
| 3X06 | Crystal structure of PIP4KIIBETA T201M complex with GMP | x-ray diffraction | A, B | — | — |
| 3X06 | Crystal structure of PIP4KIIBETA T201M complex with gmp | x-ray diffraction | A, B | — | — |
| 3X07 | Crystal structure of PIP4KIIBETA N203A complex with AMP | x-ray diffraction | A, B | — | — |
| 3X07 | Crystal structure of PIP4KIIBETA N203A complex with AMP | x-ray diffraction | A, B | — | — |
| 3X08 | Crystal structure of PIP4KIIBETA N203A complex with GMP | x-ray diffraction | A, B | — | — |
| 3X08 | Crystal structure of PIP4KIIBETA N203A complex with gmp | x-ray diffraction | A, B | — | — |
| 3X09 | Crystal structure of PIP4KIIBETA F205L complex with AMP | x-ray diffraction | A, B | — | — |
| 3X09 | Crystal structure of PIP4KIIBETA F205L complex with AMP | x-ray diffraction | A, B | — | — |
| 3X0A | Crystal structure of PIP4KIIBETA F205L complex with GMP | x-ray diffraction | A, B | — | — |
| 3X0A | Crystal structure of PIP4KIIBETA F205L complex with gmp | x-ray diffraction | A, B | — | — |
| 3X0B | Crystal structure of PIP4KIIBETA I368A complex with AMP | x-ray diffraction | A, B | — | — |
| 3X0B | Crystal structure of PIP4KIIBETA I368A complex with AMP | x-ray diffraction | A, B | — | — |
| 3X0C | Crystal structure of PIP4KIIBETA I368A complex with GMP | x-ray diffraction | A, B | — | — |
| 3X0C | Crystal structure of PIP4KIIBETA I368A complex with gmp | x-ray diffraction | A, B | — | — |
| 6K4G | Crystal structure of the PI5P4KBETA-gmppnp complex | x-ray diffraction | A, B | GNP | — |
| 6K4H | Crystal structure of the PI5P4Kbeta-AMPPNP complex | x-ray diffraction | A, B | ANP | — |
| 6K4H | Crystal structure of the PI5P4KBETA-amppnp complex | x-ray diffraction | A, B | ANP | — |
| 7EM1 | Crystal structure of the PI5P4KBETA-itp complex | x-ray diffraction | A, B | IDP, CZU | — |
| 7EM2 | Crystal structure of the PI5P4KBETA-xtp complex | x-ray diffraction | A, B | CZC, CZF | — |
| 7EM3 | Crystal structure of the PI5P4KBETA-2A-ATP complex | x-ray diffraction | A, B | CX0, CXC | — |
| 7EM4 | Crystal structure of the PI5P4Kbeta F205L-ITP complex | x-ray diffraction | A, B | IDP, CZU | 9 (best 0.61) |
| 7EM4 | Crystal structure of the PI5P4KBETA F205L-itp complex | x-ray diffraction | A, B | IDP, CZU | — |
| 7EM5 | Crystal structure of the PI5P4KBETA F205L-xtp complex | x-ray diffraction | A, B | CZC, CZF | — |
| 7EM6 | Crystal structure of the PI5P4Kbeta N203D-ITP complex | x-ray diffraction | A, B | IDP, CZU | 9 (best 0.62) |
| 7EM6 | Crystal structure of the PI5P4KBETA N203D-itp complex | x-ray diffraction | A, B | IDP, CZU | — |
| 7EM7 | Crystal structure of the PI5P4KBETA N203D-xtp complex | x-ray diffraction | A, B | CZC, CZF | — |
| 7EM8 | Crystal structure of the PI5P4KBETA T201M-2A-ATP complex | x-ray diffraction | A, B | CX0, CXC | — |
| 7N80 | Crystal structure of PI5P4KIIBETA | x-ray diffraction | A, B | — | — |
| 7N81 | Crystal Structure of PI5P4KIIBeta complex with CC260 | x-ray diffraction | A, B | HKP | 7 (best 0.74) |
| 7N81 | Crystal structure of PI5P4KIIBETA complex with CC260 | x-ray diffraction | A, B | — | — |
| P78356 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 5-phosphate 4-kinase type-2 beta (P78356) | — | — | — |
Ligands
- CZU · [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 5 records
- IDP · Inosine-5'-diphosphate · in 5 records
- CZC · [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate · in 3 records
- CZF · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 3 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- CX0 · [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate · in 2 records
- CXC · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · in 2 records
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 1 record
- HKP · (7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-[(3,5-dichloro-4-hydroxyphenyl)amino]-5-methyl-7,8-dihydropteridin-6(5H)-one · in 1 record
Elsewhere
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