CZF · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate

Binding sites

CZF in 7 structures; the first of them:

• 6TX0 · Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with xtp, dampnpp… · CZF A706 · binds LYS116, VAL117, ILE118, ILE136, ASN137, GLN142, ARG145, PHE165 and 5 more
• 6TXA · Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with xtp, dgmpnpp… · CZF A706 · binds LYS116, VAL117, ILE118, ILE136, ASN137, GLN142, ARG145, PHE165 and 6 more
• 6TXF · Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with xtp, dampnpp… · CZF A706 · binds LYS116, VAL117, ILE118, ASN137, GLN142, ARG145, PHE165, TYR155 and 4 more
• 6YOM · Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with xtp, datp… · CZF A706 · binds LYS116, VAL117, ILE118, VAL133, ILE136, ASN137, GLN142, ARG145 and 6 more
• 7EM2 · Crystal structure of the PI5P4KBETA-xtp complex · CZF A502 · binds LYS72, LYS96, TYR98, SER154, VAL157, ALA158, HIS161, ARG188 and 2 more
• 7EM5 · Crystal structure of the PI5P4KBETA F205L-xtp complex · CZF A502 · binds LYS96, TYR98, SER154, VAL157, ALA158, HIS161, ARG188, GLU195 and 1 more
• 7EM7 · Crystal structure of the PI5P4KBETA N203D-xtp complex · CZF A502 · binds LYS96, TYR98, SER154, ALA158, HIS161, ARG188, GLU195, TYR197

Residues it binds most

VAL 24, LYS 25, ARG 25, ILE 22, TYR 25, ASN 22, GLN 22, PHE 22, ALA 3, GLU 3 (residue and the binding sites it lines).

Found with

• FE · Fe (III) ion
• CZC · [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate
• MG · Magnesium ion
• DZ4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]adenosine
• MN · Manganese (II) ion
• 0KX · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]cytidine
• DTP · 2'-deoxyadenosine 5'-triphosphate
• XG4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine
• SO4 · Sulfate ion