UniProt P68135
Actin, alpha skeletal muscle (P68135)
Actin, alpha skeletal muscle (UniProt P68135), EC 3.6.4.-: 431 experimental structures and 1 predicted model on GenesisL1, 20 ligands bound, 846 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P68135
- Protein
- Actin, alpha skeletal muscle
- EC
- 3.6.4.-
- Experimental structures
- 431
- Predicted models
- 1
- Ligands
- 20
- Pockets
- 846 · 74 records with a druggable one
Structures
432 records of P68135 in the MolNFT archive: 431 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EQY | Complex between rabbit muscle alpha-actin: human gelsolin domain 1 | x-ray diffraction | A | — | — |
| 1EQY | Complex between rabbit muscle alpha-actin: human gelsolin domain 1 | x-ray diffraction | A | — | — |
| 1ESV | Complex between latrunculin A:RABBIT muscle alpha ACTIN:HUMAN gelsolin domain 1 | x-ray diffraction | A | — | — |
| 1ESV | Complex between latrunculin A:RABBIT muscle alpha ACTIN:HUMAN gelsolin domain 1 | x-ray diffraction | A | — | — |
| 1IJJ | The X-ray crystal structure of the complex between rabbit skeletal muscle actin and latrunculin a… | x-ray diffraction | A, B | — | — |
| 1IJJ | The X-ray crystal structure of the complex between rabbit skeletal muscle actin and latrunculin a… | x-ray diffraction | A, B | — | — |
| 1J6Z | Uncomplexed actin | x-ray diffraction | A | — | — |
| 1J6Z | Uncomplexed actin | x-ray diffraction | A | — | — |
| 1KXP | Crystal structure of human vitamin D-binding protein in complex with skeletal actin | x-ray diffraction | A | — | — |
| 1KXP | Crystal structure of human vitamin D-binding protein in complex with skeletal actin | x-ray diffraction | A | — | — |
| 1LCU | Polylysine Induces an Antiparallel Actin Dimer that Nucleates Filament Assembly: Crystal Structure… | x-ray diffraction | A, B | — | — |
| 1LCU | Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure… | x-ray diffraction | A, B | — | — |
| 1LOT | Crystal structure of the complex of actin with vitamin D-binding protein | x-ray diffraction | B | — | — |
| 1LOT | Crystal structure of the complex of actin with vitamin D-binding protein | x-ray diffraction | B | — | — |
| 1M8Q | Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle | electron microscopy | 7, 8, 9, V, W, X, Y, Z, 0, 1, 2, 3, 4, 5 | — | — |
| 1M8Q | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 7, 8, 9, V, W, X, Y, Z, 0, 1, 2, 3, 4, 5 | — | — |
| 1MA9 | Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin | x-ray diffraction | B | — | — |
| 1MA9 | Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin | x-ray diffraction | B | — | — |
| 1MVW | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1MVW | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1NWK | Crystal structure of monomeric actin in the ATP state | x-ray diffraction | A | — | — |
| 1NWK | Crystal structure of monomeric actin in the ATP state | x-ray diffraction | A | — | — |
| 1O18 | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O18 | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O19 | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O19 | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1A | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1A | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1B | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 0, 1, 2, 3, 4, 5, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1B | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 0, 1, 2, 3, 4, 5, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1C | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 0, 1, 2, 3, 4, 5, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1C | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 0, 1, 2, 3, 4, 5, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1D | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 0, 1, 2, 3, 4, 5, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1D | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 0, 1, 2, 3, 4, 5, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1E | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1E | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1F | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 0, 1, 2, 3, 4, 5, 6, 7, 8, V, W, X, Y, Z | — | — |
| 1O1F | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 0, 1, 2, 3, 4, 5, 6, 7, 8, V, W, X, Y, Z | — | — |
| 1O1G | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1O1G | Molecular models of averaged rigor crossbridges from tomograms of insect flight muscle | electron microscopy | 1, 2, 3, 4, 5, 6, 7, 8, 9, V, W, X, Y, Z | — | — |
| 1P8Z | Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156 | x-ray diffraction | A | — | — |
| 1P8Z | Complex between rabbit muscle alpha-actin: human gelsolin residues VAL26-GLU156 | x-ray diffraction | A | — | — |
| 1QZ5 | Structure of rabbit actin in complex with kabiramide C | x-ray diffraction | A | — | — |
| 1QZ5 | Structure of rabbit actin in complex with kabiramide C | x-ray diffraction | A | — | — |
| 1QZ6 | Structure of rabbit actin in complex with jaspisamide A | x-ray diffraction | A | — | — |
| 1QZ6 | Structure of rabbit actin in complex with jaspisamide a | x-ray diffraction | A | — | — |
| 1RDW | Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and… | x-ray diffraction | X | — | — |
| 1RDW | Actin crystal dynamics: structural implications for F-actin nucleation, polymerization and… | x-ray diffraction | X | — | — |
| 1RFQ | Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and… | x-ray diffraction | A, B | — | — |
| 1RFQ | Actin crystal dynamics: structural implications for F-actin nucleation, polymerization and… | x-ray diffraction | A, B | — | — |
| 1RGI | Crystal structure of gelsolin domains G1-G3 bound to actin | x-ray diffraction | A | — | — |
| 1RGI | Crystal structure of gelsolin domains G1-G3 bound to actin | x-ray diffraction | A | — | — |
| 1S22 | Absolute Stereochemistry of Ulapualide A | x-ray diffraction | A | — | — |
| 1S22 | Absolute stereochemistry of ulapualide a | x-ray diffraction | A | — | — |
| 1SQK | Crystal structure of ciboulot in complex with skeletal actin | x-ray diffraction | A | — | — |
| 1SQK | Crystal structure of ciboulot in complex with skeletal actin | x-ray diffraction | A | — | — |
| 1WUA | The structure of Aplyronine A-actin complex | x-ray diffraction | A | — | — |
| 1WUA | The structure of aplyronine a-actin complex | x-ray diffraction | A | — | — |
| 1Y64 | Bni1p Formin Homology 2 Domain complexed with ATP-actin | x-ray diffraction | A | — | — |
| 1Y64 | BNI1P formin homology 2 domain complexed with ATP-actin | x-ray diffraction | A | — | — |
372 records more on the page itself.
Ligands
- ADP · Adenosine-5'-diphosphate · in 147 records
- MG · Magnesium ion · in 117 records
- ATP · Adenosine-5'-triphosphate · in 40 records
- CA · Calcium ion · in 26 records
- PO4 · Phosphate ion · in 26 records
- LAB · Latrunculin B · in 16 records
- 9UE · Jasplakinolide · in 10 records
- 9ZK · (4~{R},7~{R},10~{S},13~{S},15~{E},19~{S})-10-(4-azanylbutyl)-4-(4-hydroxyphenyl)-7-(1~{H}-indol-3-ylmethyl)-8,13,15,19-tetramethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone · in 6 records
- BEF · Beryllium trifluoride ion · in 4 records
- RLZ · ~{N}-[4-[(4~{R},7~{R},10~{S},13~{S},15~{E},19~{S})-4-(4-hydroxyphenyl)-7-(1~{H}-indol-3-ylmethyl)-8,13,15, 19-tetramethyl-2,6,9,12-tetrakis(oxidanylidene)-1-oxa-5,8,11-triazacyclononadec-15-en-10-yl]butyl]-~{N}'-[5-methoxy-2-[(~{Z})-(3,4,5-trimethoxyphenyl) diazenyl]phenyl]butanediamide · in 3 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- AR6 · [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate · in 2 records
- COA · Coenzyme A · in 2 records
- CV9 · (2~{R},3~{R},5~{S},6~{E},8~{E},10~{Z},12~{S},13~{R}, 16~{Z},18~{E},20~{Z},22~{E},24~{R},25~{S},26~{E}, 28~{Z})-13-[(2~{S},3~{S},5~{S})-3,5-bis(oxidanyl) hexan-2-yl]-25-[(2~{R},3~{R},4~{S},5~{R},6~{R})-3,4-dimethoxy-6-methyl-5-oxidanyl-oxan-2-yl]oxy-3-methoxy-2,12,22,24-tetramethyl-5-oxidanyl-14,32-dioxa-33-azabicyclo[28.2.1]tritriaconta-1(33),6,8,10,16,18,20, 22,26,28,30-undecaen-15-one · in 2 records
- JQV · Mycalolide B · in 2 records
- TFJ · (1E,3R,4R,5S,6R,9S,10S,12S)-12-[(4-aminobutanoyl)oxy]-1-[ethyl(formyl)amino]-4,10-dimethoxy-3,5,9,13-tetramethyltetradec-1-en-6-yl (2R)-oxolane-2-carboxylate · in 2 records
- ACO · Acetyl coenzyme *A · in 1 record
- APR · Adenosine-5-diphosphoribose · in 1 record
- MN · Manganese (II) ion · in 1 record
- PEO · Hydrogen peroxide · in 1 record
Experiment against prediction
- 2VYP chain A against the predicted model P68135: TM-score 1.00, RMSD 0.49 Å
- 2VYP chain A against the predicted model P68135: TM-score 1.00, RMSD 0.49 Å
- 2YJE chain A against the predicted model P68135: TM-score 0.99, RMSD 0.49 Å
- 2YJE chain A against the predicted model P68135: TM-score 0.99, RMSD 0.49 Å
- 2YJE chain C against the predicted model P68135: TM-score 0.99, RMSD 0.50 Å
- 2YJE chain C against the predicted model P68135: TM-score 0.99, RMSD 0.50 Å
- 8BR0 chain A against the predicted model P68135: TM-score 0.99, RMSD 0.55 Å
- 8BR1 chain A against the predicted model P68135: TM-score 0.99, RMSD 0.55 Å
- 2FF6 chain A against the predicted model P68135: TM-score 0.99, RMSD 0.56 Å
- 2FF6 chain A against the predicted model P68135: TM-score 0.99, RMSD 0.56 Å
Elsewhere
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