UniProt P60953
Cell division control protein 42 homolog (P60953)
Cell division control protein 42 homolog (UniProt P60953), EC 3.6.5.2: 79 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P60953
- Protein
- Cell division control protein 42 homolog
- EC
- 3.6.5.2
- Experimental structures
- 79
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 5 · 1 record with a druggable one
Structures
80 records of P60953 in the MolNFT archive: 79 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A4R | G12V mutant of human placental CDC42 GTPase in the GDP form | x-ray diffraction | A, B | — | — |
| 1A4R | G12V mutant of human placental CDC42 GTPase in the GDP form | x-ray diffraction | A, B | — | — |
| 1AJE | CDC42 from human, NMR, 20 structures | solution nmr | A | — | — |
| 1AJE | CDC42 from human, NMR, 20 structures | solution nmr | A | — | — |
| 1AM4 | Complex between CDC42HS.GMPPNP and P50 rhogap (H. sapiens) | x-ray diffraction | D, E, F | — | — |
| 1AM4 | Complex between CDC42HS.GMPPNP and P50 rhogap (H. sapiens) | x-ray diffraction | D, E, F | — | — |
| 1AN0 | CDC42HS-GDP complex | x-ray diffraction | A, B | — | — |
| 1AN0 | CDC42HS-GDP complex | x-ray diffraction | A, B | — | — |
| 1CEE | Solution structure of CDC42 in complex with the GTPase binding domain of wasp | solution nmr | A | — | — |
| 1CEE | Solution structure of CDC42 in complex with the GTPase binding domain of wasp | solution nmr | A | — | — |
| 1CF4 | CDC42/ACK GTPase-binding domain complex | solution nmr | A | — | — |
| 1CF4 | CDC42/ACK GTPase-binding domain complex | solution nmr | A | — | — |
| 1DOA | Structure of the rho family gtp-binding protein cdc42 in complex with the multifunctional regulator… | x-ray diffraction | A | — | — |
| 1DOA | Structure of the rho family GTP-binding protein CDC42 in complex with the multifunctional regulator… | x-ray diffraction | A | — | — |
| 1E0A | Cdc42 complexed with the GTPase binding domain of p21 activated kinase | solution nmr | A | — | — |
| 1E0A | CDC42 complexed with the GTPase binding domain of P21 activated kinase | solution nmr | A | — | — |
| 1EES | Solution structure of CDC42HS complexed with a peptide derived from P-21 activated kinase, NMR, 20… | solution nmr | A | — | — |
| 1EES | Solution structure of CDC42HS complexed with a peptide derived from P- 21 activated kinase, NMR, 20… | solution nmr | A | — | — |
| 1GRN | Crystal structure of the CDC42/CDC42GAP/ALF3 complex. | x-ray diffraction | A | — | — |
| 1GRN | Crystal structure of the CDC42/CDC42GAP/ALF3 complex. | x-ray diffraction | A | — | — |
| 1KI1 | Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 | x-ray diffraction | A, C | — | — |
| 1KI1 | Guanine nucleotide exchange region of intersectin in complex with CDC42 | x-ray diffraction | A, C | — | — |
| 1KZ7 | Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of… | x-ray diffraction | B, D | — | — |
| 1KZ7 | Crystal structure of the DH/PH fragment of murine dbs in complex with the placental isoform of… | x-ray diffraction | B, D | — | — |
| 1KZG | DbsCdc42(Y889F) | x-ray diffraction | B, D | — | — |
| 1KZG | DBSCDC42(Y889F) | x-ray diffraction | B, D | — | — |
| 1NF3 | Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6 | x-ray diffraction | A, B | — | — |
| 1NF3 | Structure of CDC42 in a complex with the GTPase-binding domain of the cell polarity protein, PAR6 | x-ray diffraction | A, B | — | — |
| 2ASE | NMR structure of the F28L mutant of Cdc42Hs | solution nmr | A | — | — |
| 2ASE | NMR structure of the F28L mutant of CDC42HS | solution nmr | A | — | — |
| 2DFK | Crystal structure of the CDC42-Collybistin II complex | x-ray diffraction | B, D | — | — |
| 2DFK | Crystal structure of the CDC42-collybistin II complex | x-ray diffraction | B, D | — | — |
| 2KB0 | Cdc42(T35A) | solution nmr | A | — | — |
| 2KB0 | CDC42(T35A) | solution nmr | A | — | — |
| 2NGR | Transition state complex for GTP hydrolysis by CDC42: comparisons of the high resolution structures… | x-ray diffraction | A | — | — |
| 2NGR | Transition state complex for GTP hydrolysis by CDC42: comparisons of the high resolution structures… | x-ray diffraction | A | — | — |
| 2ODB | The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase… | x-ray diffraction | A | — | — |
| 2ODB | The crystal structure of human CDC42 in complex with the crib domain of human P21-activated kinase… | x-ray diffraction | A | — | — |
| 2QRZ | Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required | x-ray diffraction | A, B | — | — |
| 2QRZ | CDC42 bound to gmp-pcp: induced fit by effector is required | x-ray diffraction | A, B | — | — |
| 2WM9 | Structure of the complex between DOCK9 and Cdc42. | x-ray diffraction | B | — | — |
| 2WM9 | Structure of the complex between DOCK9 and CDC42. | x-ray diffraction | B | — | — |
| 2WMN | Structure of the complex between DOCK9 and Cdc42-GDP. | x-ray diffraction | B | — | — |
| 2WMN | Structure of the complex between DOCK9 and CDC42-GDP. | x-ray diffraction | B | — | — |
| 2WMO | Structure of the complex between DOCK9 and Cdc42. | x-ray diffraction | B | — | — |
| 2WMO | Structure of the complex between DOCK9 and CDC42. | x-ray diffraction | B | — | — |
| 3GCG | crystal structure of MAP and CDC42 complex | x-ray diffraction | A | — | — |
| 3GCG | Crystal structure of MAP and CDC42 complex | x-ray diffraction | A | — | — |
| 3QBV | Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of… | x-ray diffraction | A, C | — | — |
| 3QBV | Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of… | x-ray diffraction | A, C | — | — |
| 3VHL | Crystal structure of the DHR-2 domain of DOCK8 in complex with Cdc42 (T17N mutant) | x-ray diffraction | B | — | — |
| 3VHL | Crystal structure of the dhr-2 domain of DOCK8 in complex with CDC42 (T17N mutant) | x-ray diffraction | B | — | — |
| 4DID | Crystal structure of Salmonella effector N-terminal domain SopB in complex with Cdc42 | x-ray diffraction | A | — | — |
| 4DID | Crystal structure of salmonella effector N-terminal domain sopb in complex with CDC42 | x-ray diffraction | A | — | — |
| 4ITR | Crystal Structure of IbpAFic2-H3717A in complex with adenylylated Cdc42 | x-ray diffraction | C, D | — | — |
| 4ITR | Crystal structure of IBPAFIC2-H3717A in complex with adenylylated CDC42 | x-ray diffraction | C, D | — | — |
| 4JS0 | Complex of Cdc42 with the CRIB-PR domain of IRSp53 | x-ray diffraction | A | — | — |
| 4JS0 | Complex of CDC42 with the crib-pr domain of IRSP53 | x-ray diffraction | A | — | — |
| 4YC7 | Crystal structure of human FMNL2 GBD-FH3 Domains bound to Cdc42-GppNHp | x-ray diffraction | A | — | — |
| 4YC7 | Crystal structure of human FMNL2 gbd-FH3 domains bound to CDC42-gppnhp | x-ray diffraction | A | — | — |
20 records more on the page itself.
Ligands
- GDP · Guanosine-5'-diphosphate · in 6 records
- MG · Magnesium ion · in 3 records
- SO4 · Sulfate ion · in 3 records
- LJN · [(2~{R},3~{S},4~{R},5~{R})-5-[4-(acetamidomethyl)-1,2, 3-triazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate · in 2 records
- FMN · Flavin mononucleotide · in 1 record
- GNP · Phosphoaminophosphonic acid-guanylate ester · in 1 record
- UDP · Uridine-5'-diphosphate · in 1 record
Experiment against prediction
- 4JS0 chain A against the predicted model P60953: TM-score 0.99, RMSD 0.41 Å
- 4JS0 chain A against the predicted model P60953: TM-score 0.99, RMSD 0.41 Å
- 2ODB chain A against the predicted model P60953: TM-score 0.99, RMSD 0.45 Å
- 2ODB chain A against the predicted model P60953: TM-score 0.99, RMSD 0.45 Å
- 5UPL chain B against the predicted model P60953: TM-score 0.99, RMSD 0.51 Å
- 5UPL chain B against the predicted model P60953: TM-score 0.99, RMSD 0.51 Å
- 4YC7 chain A against the predicted model P60953: TM-score 0.99, RMSD 0.47 Å
- 4YC7 chain A against the predicted model P60953: TM-score 0.99, RMSD 0.47 Å
- 5UPK chain C against the predicted model P60953: TM-score 0.98, RMSD 0.63 Å
- 4YDH chain B against the predicted model P60953: TM-score 0.98, RMSD 0.63 Å
Elsewhere
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