UniProt P43405
Tyrosine-protein kinase SYK (P43405)
Tyrosine-protein kinase SYK (UniProt P43405), EC 2.7.10.2: 142 experimental structures and 1 predicted model on GenesisL1, 28 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P43405
- Protein
- Tyrosine-protein kinase SYK
- EC
- 2.7.10.2
- Experimental structures
- 142
- Predicted models
- 1
- Ligands
- 28
- Pockets
- 9 · 6 records with a druggable one
Structures
143 records of P43405 in the MolNFT archive: 142 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A81 | Crystal structure of the tandem SH2 domain of the syk kinase bound to a dually… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1A81 | Crystal structure of the tandem SH2 domain of the syk kinase bound to a dually… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1CSY | Syk tyrosine kinase C-terminal SH2 domain complexed with a phosphopeptidefrom the gamma chain of… | solution nmr | A | — | — |
| 1CSY | Syk tyrosine kinase C-terminal SH2 domain complexed with a phosphopeptidefrom the gamma chain of… | solution nmr | A | — | — |
| 1CSZ | Syk tyrosine kinase C-terminal SH2 domain complexed with a phosphopeptidefrom the gamma chain of… | solution nmr | A | — | — |
| 1CSZ | Syk tyrosine kinase C-terminal SH2 domain complexed with a phosphopeptidefrom the gamma chain of… | solution nmr | A | — | — |
| 1XBA | Crystal structure of apo syk tyrosine kinase domain | x-ray diffraction | A | — | — |
| 1XBA | Crystal structure of apo syk tyrosine kinase domain | x-ray diffraction | A | — | — |
| 1XBB | Crystal structure of the syk tyrosine kinase domain with Gleevec | x-ray diffraction | A | — | — |
| 1XBB | Crystal structure of the syk tyrosine kinase domain with gleevec | x-ray diffraction | A | — | — |
| 1XBC | Crystal structure of the syk tyrosine kinase domain with Staurosporin | x-ray diffraction | A | — | — |
| 1XBC | Crystal structure of the syk tyrosine kinase domain with staurosporin | x-ray diffraction | A | — | — |
| 3BUW | Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk | x-ray diffraction | A, C | — | — |
| 3BUW | Crystal structure of C-cbl-tkb domain complexed with its binding motif in syk | x-ray diffraction | A, C | — | — |
| 3EMG | Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen… | x-ray diffraction | A | — | — |
| 3EMG | Discovery and sar of novel 4-thiazolyl-2- phenylaminopyrimidines as potent inhibitors of spleen… | x-ray diffraction | A | — | — |
| 3FQE | Crystal structure of spleen tyrosine kinase complexed with YM193306 | x-ray diffraction | A | — | — |
| 3FQE | Crystal structure of spleen tyrosine kinase complexed with YM193306 | x-ray diffraction | A | — | — |
| 3FQH | Crystal structure of spleen tyrosine kinase complexed with a 2-substituted 7-azaindole | x-ray diffraction | A, B | — | — |
| 3FQH | Crystal structure of spleen tyrosine kinase complexed with a 2- substituted 7-azaindole | x-ray diffraction | A, B | — | — |
| 3FQS | Crystal structure of spleen tyrosine kinase complexed with R406 | x-ray diffraction | A | — | — |
| 3FQS | Crystal structure of spleen tyrosine kinase complexed with R406 | x-ray diffraction | A | — | — |
| 3SRV | Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide… | x-ray diffraction | A, B | — | — |
| 3SRV | Crystal structure of spleen tyrosine kinase (syk) in complex with a diaminopyrimidine carboxamide… | x-ray diffraction | A, B | — | — |
| 3TUB | Crystal structure of SYK kinase domain with 1-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-3-((1R… | x-ray diffraction | A | — | — |
| 3TUB | Crystal structure of syk kinase domain with 1-(5-(6,7… | x-ray diffraction | A | — | — |
| 3TUC | Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-y… | x-ray diffraction | A | — | — |
| 3TUC | Crystal structure of syk kinase domain with 1-benzyl-N-(5-(6,7… | x-ray diffraction | A | — | — |
| 3TUD | Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydr… | x-ray diffraction | A | — | — |
| 3TUD | Crystal structure of syk kinase domain with N-(4-methyl-3-(8-methyl-7… | x-ray diffraction | A | — | — |
| 3VF8 | Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Pyrazolylbenzimidazole… | x-ray diffraction | A | — | — |
| 3VF8 | Crystal structure of spleen tyrosine kinase syk catalytic domain with pyrazolylbenzimidazole… | x-ray diffraction | A | — | — |
| 3VF9 | Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Thienopyrazolylindole… | x-ray diffraction | A | — | — |
| 3VF9 | Crystal structure of spleen tyrosine kinase syk catalytic domain with thienopyrazolylindole… | x-ray diffraction | A | — | — |
| 4DFL | Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine… | x-ray diffraction | A | — | — |
| 4DFL | Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine… | x-ray diffraction | A | — | — |
| 4DFN | Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor | x-ray diffraction | A | — | — |
| 4DFN | Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor | x-ray diffraction | A | — | — |
| 4F4P | SYK in COMPLEX WITH LIGAND LASW836 | x-ray diffraction | A | — | — |
| 4F4P | Syk in complex with ligand LASW836 | x-ray diffraction | A | — | — |
| 4FL1 | Structural and Biophysical Characterization of the Syk Activation Switch | x-ray diffraction | A | — | — |
| 4FL1 | Structural and biophysical characterization of the syk activation switch | x-ray diffraction | A | — | — |
| 4FL2 | Structural and Biophysical Characterization of the Syk Activation Switch | x-ray diffraction | A | — | — |
| 4FL2 | Structural and biophysical characterization of the syk activation switch | x-ray diffraction | A | — | — |
| 4FL3 | Structural and Biophysical Characterization of the Syk Activation Switch | x-ray diffraction | A | — | — |
| 4FL3 | Structural and biophysical characterization of the syk activation switch | x-ray diffraction | A | — | — |
| 4FYN | Crystal structure of spleen tyrosine kinase complexed with… | x-ray diffraction | A | — | — |
| 4FYN | Crystal structure of spleen tyrosine kinase complexed with 3-(8-{4… | x-ray diffraction | A | — | — |
| 4FYO | Crystal structure of spleen tyrosine kinase complexed with… | x-ray diffraction | A | — | — |
| 4FYO | Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1… | x-ray diffraction | A | — | — |
| 4FZ6 | Crystal structure of spleen tyrosine kinase complexed with… | x-ray diffraction | A | — | — |
| 4FZ6 | Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2… | x-ray diffraction | A | — | — |
| 4FZ7 | Crystal structure of spleen tyrosine kinase complexed with… | x-ray diffraction | A | — | — |
| 4FZ7 | Crystal structure of spleen tyrosine kinase complexed with 6-((1R,2S)… | x-ray diffraction | A | — | — |
| 4GFG | Crystal structure of spleen tyrosine kinase complexed with r9021 | x-ray diffraction | A | — | — |
| 4GFG | Crystal structure of spleen tyrosine kinase complexed with R9021 | x-ray diffraction | A | — | — |
| 4I0R | Crystal structure of spleen tyrosine kinase complexed with… | x-ray diffraction | A | — | — |
| 4I0R | Crystal structure of spleen tyrosine kinase complexed with 2-(3,4,5… | x-ray diffraction | A | — | — |
| 4I0S | Crystal structure of spleen tyrosine kinase complexed with… | x-ray diffraction | A | — | — |
| 4I0S | Crystal structure of spleen tyrosine kinase complexed with 2-(6… | x-ray diffraction | A | — | — |
83 records more on the page itself.
Ligands
- 5JG · 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine · in 2 records
- 6ZF · 7-[6-(dimethylamino)pyridin-3-yl]-~{N}-[[(3~{S})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine · in 2 records
- GDK · 2-(4-methylphenyl)-3-(pyridin-2-ylmethoxy)pyridine · in 2 records
- QF8 · ~{N},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{R})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide · in 2 records
- 3YT · 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide · in 1 record
- 4DQ · N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-N~4~-ethyl-5-fluoro-N~4~-(1H-indazol-4-yl)pyrimidine-2,4-diamine · in 1 record
- 4DT · 3-[6-({4-[ethyl(1H-indazol-4-yl)amino]-5-fluoropyrimidin-2-yl}amino)-2,4-dihydro-1H-indazol-1-yl]propan-1-ol · in 1 record
- 55M · (4R)-4-[(1R)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one · in 1 record
- 55U · N-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine · in 1 record
- 6ZG · ~{N}'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine · in 1 record
- 77V · N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3, 2-d]pyrimidine-2,4-diamine · in 1 record
- 7CU · 5-{[(2S)-2-aminopropyl]amino}-3-(1H-indol-2-yl) pyrazine-2-carboxamide · in 1 record
- 7KF · 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one · in 1 record
- 7KG · 6-{[(1R,2S)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one · in 1 record
- 8OR · 2-[[(1S,2S)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6H-pyrido[4,3-d]pyrimidin-5-one · in 1 record
- 8OU · 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one · in 1 record
- BR · Bromide ion · in 1 record
- CL · Chloride ion · in 1 record
- GDH · 7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{H}-3-benzazepine · in 1 record
- LUE · ~{N}-[4-[5-[(dimethylamino)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-yl]-3-methyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)imidazo[1,5-a]pyridin-7-amine · in 1 record
- PO4 · Phosphate ion · in 1 record
- QDZ · ~{N},~{N}-dimethyl-1-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]methanamine · in 1 record
- QFB · 7-[[4-[4-[[(3~{R},4~{R})-3-azanyloxan-4-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{N},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide · in 1 record
- QFE · (3~{R},4~{R})-~{N}4-[1-[2-(1-methylindol-4-yl)-3~{H}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine · in 1 record
- QFK · 7-[[4-[4-[(dimethylamino)methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{N},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide · in 1 record
- QFQ · ~{N},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{R})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide · in 1 record
- R6D · 6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine · in 1 record
- X6G · 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol · in 1 record
Experiment against prediction
- 4FL3 chain A against the predicted model P43405: TM-score 0.99, RMSD 0.67 Å
- 4FL3 chain A against the predicted model P43405: TM-score 0.99, RMSD 0.67 Å
- 4FL2 chain A against the predicted model P43405: TM-score 0.98, RMSD 1.12 Å
- 4FL2 chain A against the predicted model P43405: TM-score 0.98, RMSD 1.12 Å
- 3TUC chain A against the predicted model P43405: TM-score 0.92, RMSD 1.87 Å
- 3TUC chain A against the predicted model P43405: TM-score 0.92, RMSD 1.87 Å
- 3FQH chain B against the predicted model P43405: TM-score 0.92, RMSD 1.78 Å
- 3FQH chain B against the predicted model P43405: TM-score 0.92, RMSD 1.78 Å
- 4XG9 chain A against the predicted model P43405: TM-score 0.92, RMSD 1.80 Å
- 4XG8 chain C against the predicted model P43405: TM-score 0.92, RMSD 1.62 Å
Elsewhere
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