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Ligand · 2X6

2X6 · 7-{[(1R,2S)-2-aminocyclohexyl]amino}-5-(1H-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one

2X6, 7-{[(1R,2S)-2-aminocyclohexyl]amino}-5-(1H-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one (C21 H23 N7 O, 389.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
2X6
Formula
C21 H23 N7 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

2X6 in 2 structures; the first of them:

  • 4PX6 · SYK catalytic domain in complex with a potent pyridopyrimidi inhibitor · 2X6 A701 · binds LEU377, SER379, PHE382, VAL385, ALA400, LYS402, VAL433, MET448 and 12 more
  • 4PX6 · Syk catalytic domain in complex with a potent pyridopyrimidinone inhibitor · 2X6 A701 · binds LEU377, SER379, PHE382, VAL385, ALA400, LYS402, VAL433, MET448 and 12 more

Residues it binds most

LEU 2, ALA 2, GLU 2, MET 2, SER 2, VAL 2, ARG 2, ASN 2, ASP 2, GLY 2 (residue and the binding sites it lines).

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