UniProt P43004
Excitatory amino acid transporter 2 (P43004)
Excitatory amino acid transporter 2 (UniProt P43004): 7 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 46 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P43004
- Protein
- Excitatory amino acid transporter 2
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 46 · 3 records with a druggable one
Structures
8 records of P43004 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7VR7 | Inward-facing structure of human EAAT2 in the WAY213613-bound state | electron microscopy | A | GJ0, 9Z9, CLR, PC1 | 6 (best 0.74) |
| 7VR7 | Inward-facing structure of human EAAT2 in the WAY213613-bound state | electron microscopy | A | GJ0, 9Z9, CLR, PC1 | — |
| 7VR8 | Inward-facing structure of human EAAT2 in the substrate-free state | electron microscopy | A | 9Z9, CLR, PC1 | — |
| 7XR4 | Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate | electron microscopy | A, B, C | GLU, Y01, PC1 | 20 (best 0.88) |
| 7XR4 | Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate | electron microscopy | A, B, C | Y01, PC1 | — |
| 7XR6 | Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613 | electron microscopy | A, B, C | GJ0, Y01, PC1, XKJ | 20 (best 0.88) |
| 7XR6 | Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with way-213613 | electron microscopy | A, B, C | GJ0, Y01, PC1, XKJ | — |
| P43004 | AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 2 (P43004) | predicted | A | — | — |
Ligands
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 7 records
- GJ0 · (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl) phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid · in 4 records
- Y01 · Cholesterol hemisuccinate · in 4 records
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 3 records
- CLR · Cholesterol · in 3 records
- XKJ · dodecyl beta-D-glucopyranoside · in 2 records
- GLU · Glutamic acid · in 1 record
Experiment against prediction
- 7XR4 chain B against the predicted model P43004: TM-score 0.63, RMSD 5.01 Å
- 7XR4 chain C against the predicted model P43004: TM-score 0.63, RMSD 5.01 Å
- 7XR4 chain A against the predicted model P43004: TM-score 0.63, RMSD 5.01 Å
- 7XR4 chain B against the predicted model P43004: TM-score 0.63, RMSD 5.01 Å
- 7XR4 chain C against the predicted model P43004: TM-score 0.63, RMSD 5.01 Å
- 7XR4 chain A against the predicted model P43004: TM-score 0.63, RMSD 5.01 Å
- 7VR7 chain A against the predicted model P43004: TM-score 0.63, RMSD 4.99 Å
- 7VR7 chain A against the predicted model P43004: TM-score 0.63, RMSD 4.99 Å
- 7VR8 chain A against the predicted model P43004: TM-score 0.63, RMSD 5.03 Å
- 7XR6 chain B against the predicted model P43004: TM-score 0.62, RMSD 4.97 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.