MolNFT v1 · #190650 · protein

Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with way-213613

7XR6: “Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with way-213613”. Electron microscopy, 4 ligands (PC1, GJ0, Y01). MolNFT v1 #190650 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7XR6
Type: protein
Length: 1,272 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P43004
Ligands: PC1, GJ0, Y01, XKJ

Structure

electron microscopy · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	—	protein	424	—	P43004

Ligands and binding sites

PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 30 copies · chains A, B, C
GJ0 · (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl) phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid · ligand · 3 copies · chains A, B, C
Y01 · Cholesterol hemisuccinate · ligand · 3 copies · chains A, B, C
XKJ · dodecyl beta-D-glucopyranoside · ligand · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7XR6 · Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613 · the same entry in another collection · chain A against A, TM-score 1.00
P43004 · AlphaFold monomer V2.0 prediction for excitatory amino acid transporter 2 (P43004) · a predicted model of the same protein · chain B against A, TM-score 0.62

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43004
Elsewhere: RCSB PDB 7XR6 · PDBe 7XR6 · UniProt P43004

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