UniProt P42262
Glutamate receptor 2 (P42262)
Glutamate receptor 2 (UniProt P42262): 31 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P42262
- Protein
- Glutamate receptor 2
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 59 · 7 records with a druggable one
Structures
32 records of P42262 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WJW | Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 1.8 A resolution | x-ray diffraction | A | — | — |
| 2WJW | Crystal structure of the human ionotropic glutamate receptor GLUR2 atd region at 1.8 a resolution | x-ray diffraction | A | — | — |
| 2WJX | Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution | x-ray diffraction | A, B, C | — | — |
| 2WJX | Crystal structure of the human ionotropic glutamate receptor GLUR2 atd region at 4.1 a resolution | x-ray diffraction | A, B, C | — | — |
| 2XHD | Crystal structure of N-((2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H… | x-ray diffraction | A, B | — | — |
| 2XHD | Crystal structure of N-((2S)-5-(6-fluoro-3-pyridinyl)-2,3… | x-ray diffraction | A, B | — | — |
| 3R7X | Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of… | x-ray diffraction | A, B | — | — |
| 3R7X | Crystal structure analysis of a quinazolinedione sulfonamide bound to human GLUR2: a novel class of… | x-ray diffraction | A, B | — | — |
| 3RN8 | Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator | x-ray diffraction | A, B, C | — | — |
| 3RN8 | Crystal structure of IGLUR2 ligand binding domain and symmetrical carboxyl containing potentiator | x-ray diffraction | A, B, C | — | — |
| 3RNN | Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator | x-ray diffraction | A, B, C | — | — |
| 3RNN | Crystal structure of IGLUR2 ligand binding domain with symmetric sulfonamide containing potentiator | x-ray diffraction | A, B, C | — | — |
| 3UA8 | Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2 | x-ray diffraction | A | — | — |
| 3UA8 | Crystal structure analysis of a 6-amino quinazolinedione sulfonamide bound to human GLUR2 | x-ray diffraction | A | — | — |
| 5H8S | Structure of the human GluA2 LBD in complex with GNE3419 | x-ray diffraction | A, C, B | GLU, 5YC, ZN | 7 (best 0.78) |
| 5H8S | Structure of the human GLUA2 lbd in complex with GNE3419 | x-ray diffraction | A, C, B | — | — |
| 5YBF | Crystal structure of the GluA2o LBD in complex with glutamate and HBT1 | x-ray diffraction | A, B, C, D, E, F | 8SR, ZN | — |
| 5YBF | Crystal structure of the GLUA2O lbd in complex with glutamate and HBT1 | x-ray diffraction | A, B, C, D, E, F | 8SR, ZN | — |
| 5YBG | Crystal structure of the GluA2o LBD in complex with glutamate and LY451395 | x-ray diffraction | A, B, C, D, E, F | 8SO, ZN | — |
| 5YBG | Crystal structure of the GLUA2O lbd in complex with glutamate and LY451395 | x-ray diffraction | A, B, C, D, E, F | 8SO, ZN | — |
| 5ZG0 | Crystal structure of the GluA2o LBD in complex with glutamate and Compound-1 | x-ray diffraction | A, B, C, D, E, F | GLU, ZN, 9C3 | 15 (best 0.83) |
| 5ZG0 | Crystal structure of the GLUA2O lbd in complex with glutamate and compound-1 | x-ray diffraction | A, B, C, D, E, F | ZN, 9C3 | — |
| 5ZG1 | Crystal structure of the GluA2o LBD in complex with glutamate and Compound-2 | x-ray diffraction | A, B | GLU, 9C0, SO4 | 4 (best 0.80) |
| 5ZG1 | Crystal structure of the GLUA2O lbd in complex with glutamate and compound-2 | x-ray diffraction | A, B | 9C0, SO4 | — |
| 5ZG2 | Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2 | x-ray diffraction | A, B | ZK1, 9C0, ZN | 3 (best 0.77) |
| 5ZG2 | Crystal structure of the GLUA2O lbd in complex with ZK200775 and compound-2 | x-ray diffraction | A, B | ZK1, 9C0, ZN | — |
| 5ZG3 | Crystal structure of the GluA2o LBD in complex with glutamate and TAK-137 | x-ray diffraction | A, B, C, D, E, F | 9C6, GLU, ZN | 13 (best 0.83) |
| 5ZG3 | Crystal structure of the GLUA2O lbd in complex with glutamate and tak- 137 | x-ray diffraction | A, B, C, D, E, F | 9C6, ZN | — |
| 7F3O | Crystal structure of the GluA2o LBD in complex with glutamate and TAK-653 | x-ray diffraction | A, B, C, D, E, F | GLU, 0YK, ZN | 13 (best 0.82) |
| 7F3O | Crystal structure of the GLUA2O lbd in complex with glutamate and tak- 653 | x-ray diffraction | A, B, C, D, E, F | 0YK, ZN | — |
| 8I0B | The crystal structure of human glutamate receptor 2 in complex with LT-102 | x-ray diffraction | A, B | SO4, NXO, NA, CL | 4 (best 0.78) |
| P42262 | AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P42262) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 13 records
- GLU · Glutamic acid · in 5 records
- 9C0 · 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-C][1,2, 4]thiadiazine 2,2-dioxide · in 4 records
- SO4 · Sulfate ion · in 3 records
- 0YK · 7-(4-cyclohexyloxyphenyl)-9-methyl-4$l^{6}-thia-1$l^{4},5,8-triazabicyclo[4.4.0]deca-1(10),6,8-triene 4,4-dioxide · in 2 records
- 8SO · N-[(2R)-2-[4-[4-[2-(methylsulfonylamino) ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide · in 2 records
- 8SR · 2-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide · in 2 records
- 9C3 · 9-{4-[(propan-2-yl)oxy]phenyl}-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione · in 2 records
- 9C6 · 9-(4-phenoxyphenyl)-3,4-dihydro-2H-2lambda~6~-pyrido[2, 1-c][1,2,4]thiadiazine-2,2-dione · in 2 records
- ZK1 · {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid · in 2 records
- 5YC · 7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one · in 1 record
- CL · Chloride ion · in 1 record
- NA · Sodium ion · in 1 record
- NXO · 8-[4-(2-fluorophenyl)phenyl]-3,4-dihydro-1,2$l^{6},3-benzoxathiazine 2,2-dioxide · in 1 record
Experiment against prediction
- 5ZG3 chain E against the predicted model P42262: TM-score 0.98, RMSD 0.83 Å
- 5ZG3 chain A against the predicted model P42262: TM-score 0.98, RMSD 0.84 Å
- 5ZG0 chain A against the predicted model P42262: TM-score 0.98, RMSD 0.85 Å
- 5ZG0 chain E against the predicted model P42262: TM-score 0.98, RMSD 0.86 Å
- 7F3O chain E against the predicted model P42262: TM-score 0.98, RMSD 1.00 Å
- 7F3O chain A against the predicted model P42262: TM-score 0.98, RMSD 1.00 Å
- 5H8S chain A against the predicted model P42262: TM-score 0.98, RMSD 0.91 Å
- 5ZG3 chain A against the predicted model P42262: TM-score 0.98, RMSD 0.84 Å
- 5ZG0 chain A against the predicted model P42262: TM-score 0.98, RMSD 0.85 Å
- 3RNN chain A against the predicted model P42262: TM-score 0.98, RMSD 0.87 Å
Elsewhere
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