MolNFT v1 · #80878 · protein
Crystal structure analysis of a 6-amino quinazolinedione sulfonamide bound to human GLUR2
3UA8 · Glutamate receptor 2: “Crystal structure analysis of a 6-amino quinazolinedione sulfonamide bound to human GLUR2”. X-ray diffraction, 1 ligand (08W), 1 pocket (best druggability 0.57). MolNFT v1 #80878 on GenesisL1: 3D structure…
- PDB
- 3UA8
- Type
- protein
- Length
- 257 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P42262
- Ligands
- 08W
- Pockets
- 1 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor 2 | protein | 257 | 39% helix, 21% strand | P42262 |
Ligands and binding sites
- 08W · N-methyl-1-{3-[(methylsulfonyl)amino]-2,4-dioxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-6-yl}-1H-imidazole-4-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.57 | 0.78 | 34 | 08W |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3UA8 · Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2 · the same entry in another collection · chain A against A, TM-score 1.00
- P42262 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P42262) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42262
- Elsewhere: RCSB PDB 3UA8 · PDBe 3UA8 · UniProt P42262
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