MolNFT v1 · #53076 · protein
Crystal structure of the human ionotropic glutamate receptor GLUR2 atd region at 1.8 a resolution
2WJW · Glutamate receptor 2: “Crystal structure of the human ionotropic glutamate receptor GLUR2 atd region at 1.8 a resolution”. X-ray diffraction, 3 ligands (NAG, CL, SO4), 4 pockets (best druggability 0.73). MolNFT v1 #53076 on…
- PDB
- 2WJW
- Type
- protein
- Length
- 368 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P42262
- Ligands
- NAG, CL, SO4
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor 2 | protein | 368 | 37% helix, 22% strand | P42262 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
- CL · Chloride ion · ion · chains A
- SO4 · Sulfate ion · ion · chains A
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 547 | 0.73 | 0.81 | 51 | empty |
| 2 | 53 | 0.31 | 0.76 | 12 | empty |
| 3 | 56 | 0.30 | 0.75 | 18 | empty |
| 4 | 56 | 0.28 | 0.74 | 12 | empty |
Modifications
Observed in the structure: 1 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 2WJW · Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 1.8 A… · the same entry in another collection · chain A against A, TM-score 1.00
- P42262 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P42262) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42262
- Elsewhere: RCSB PDB 2WJW · PDBe 2WJW · UniProt P42262
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.