UniProt P36544
Neuronal acetylcholine receptor subunit alpha-7 (P36544)
Neuronal acetylcholine receptor subunit alpha-7 (UniProt P36544): 34 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 488 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P36544
- Protein
- Neuronal acetylcholine receptor subunit alpha-7
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 488 · 27 records with a druggable one
Structures
35 records of P36544 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MAW | NMR structures of the alpha7 nAChR transmembrane domain. | solution nmr | A | — | 2 (best 0.81) |
| 2MAW | NMR structures of the ALPHA7 nachr transmembrane domain. | solution nmr | A | — | 2 (best 0.81) |
| 7EKI | human alpha 7 nicotinic acetylcholine receptor in apo-form | electron microscopy | A, B, C, D, E | NAG, CLR | 20 (best 0.79) |
| 7EKI | Human alpha 7 nicotinic acetylcholine receptor in apo-form | electron microscopy | A, B, C, D, E | NAG, CLR | — |
| 7EKP | human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 | electron microscopy | A, B, C, D, E | NAG, I33, CLR | 20 (best 0.83) |
| 7EKP | Human alpha 7 nicotinic acetylcholine receptor bound to evp-6124 | electron microscopy | A, B, C, D, E | NAG, I33, CLR | — |
| 7EKT | human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596 | electron microscopy | A, B, C, D, E | NAG, CLR, I33, I34 | 20 (best 0.82) |
| 7EKT | Human alpha 7 nicotinic acetylcholine receptor bound to evp-6124 and pnu-120596 | electron microscopy | A, B, C, D, E | NAG, CLR, I33, I34 | — |
| 7KOO | Alpha-7 nicotinic acetylcholine receptor bound to alpha-bungarotoxin in a resting state | electron microscopy | A, B, C, D, E | NAG, MAN, CA | 20 (best 0.78) |
| 7KOO | Alpha-7 nicotinic acetylcholine receptor bound to alpha-bungarotoxin in a resting state | electron microscopy | A, B, C, D, E | NAG, MAN, CA | — |
| 7KOQ | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine in a desensitized state | electron microscopy | A, B, C, D, E | NAG, EPJ, CA | 20 (best 0.81) |
| 7KOQ | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine in a desensitized state | electron microscopy | A, B, C, D, E | NAG, EPJ, CA | — |
| 7KOX | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and PNU-120596 in the activated state | electron microscopy | A, B, C, D, E | NAG, EPJ, CA | 20 (best 0.77) |
| 7KOX | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and pnu- 120596 in the activated state | electron microscopy | A, B, C, D, E | NAG, EPJ, CA | — |
| 7RPM | Structures of the Intracellular Domain and Transmembrane Domain of the Human alpha7 Nicotinic… | solution nmr | A, B, C, D, E | — | 20 (best 0.91) |
| 7RPM | Structures of the intracellular domain and transmembrane domain of the human ALPHA7 nicotinic… | solution nmr | A, B, C, D, E | — | — |
| 8C9X | human alpha7 nicotinic receptor in complex with the C4 nanobody | electron microscopy | A, B, C, D, E | NAG | 20 (best 0.69) |
| 8CAU | human alpha7 nicotinic receptor in complex with the C4 nanobody and nicotine | electron microscopy | A, B, C, D, E | NAG, NCT | 20 (best 0.74) |
| 8CE4 | Human alpha7 nicotinic receptor in complex with the E3 nanobody | electron microscopy | A, B, C, D, E | NAG | 20 (best 0.76) |
| 8CI1 | Human alpha7 nicotinic receptor in complex with the E3 nanobody and nicotine | electron microscopy | A, B, C, D, E | NAG, NCT | 20 (best 0.74) |
| 8CI2 | human alpha7 nicotinic receptor in complex with the C4 nanobody under sub-saturating conditions | electron microscopy | A, B, C, D, E | NAG | 20 (best 0.74) |
| 8F4V | Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin… | solution nmr | A, B, C, D, E | IVM | 20 (best 0.86) |
| 8P1H | Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment… | x-ray diffraction | A, B | AZI, BEZ | 4 (best 0.72) |
| 8UT1 | Alpha7-nicotinic acetylcholine receptor bound to epibatidine | electron microscopy | A, B, C, D, E | NAG, CA, POV, 9Z9, EPJ | 20 (best 0.82) |
| 8UTB | Alpha7-nicotinic acetylcholine receptor bound to epibatidine and NS-1738 | electron microscopy | A, B, C, D, E | NAG, XG3, EPJ, 9Z9, POV | 20 (best 0.83) |
| 8UZJ | Alpha7-nicotinic acetylcholine receptor bound to epibatidine and ivermectin | electron microscopy | A, B, C, D, E | NAG, CA, 9Z9, EPJ, IVM, POV | 20 (best 0.83) |
| 8V80 | Alpha7-nicotinic acetylcholine receptor bound to epibatidine and (-)-TQS | electron microscopy | A, B, C, D, E | NAG, CA, POV, 9Z9, EPJ, YLR | 20 (best 0.87) |
| 8V82 | Alpha7-nicotinic acetylcholine receptor bound to epibatidine and PNU-120596 | electron microscopy | A, B, C, D, E | NAG, CA, POV, 9Z9, EPJ, I34 | 20 (best 0.84) |
| 8V86 | Alpha7-nicotinic acetylcholine receptor bound to GAT107 | electron microscopy | A, B, C, D, E | NAG, POV, 9Z9, YLI | 20 (best 0.79) |
| 8V88 | Alpha7-nicotinic acetylcholine receptor bound to epibatidine and GAT107 | electron microscopy | A, B, C, D, E | NAG, CA, POV, 9Z9, EPJ, YLI | 20 (best 0.82) |
| 8V89 | Alpha7-nicotinic acetylcholine receptor time resolved resting state | electron microscopy | A, B, C, D, E | NAG, R16, 9Z9, POV | 20 (best 0.81) |
| 8V8A | Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596… | electron microscopy | A, B, C, D, E | NAG, CA, POV, 9Z9, EPJ, I34 | 20 (best 0.81) |
| 8V8C | Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596… | electron microscopy | A, B, C, D, E | NAG, EPJ, I34, CA | 20 (best 0.81) |
| 8V8D | Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596… | electron microscopy | A, B, C, D, E | NAG, EPJ, I34, CA | 20 (best 0.85) |
| P36544 | AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit alpha-7 (P36544) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 28 records
- CA · Calcium ion · in 14 records
- EPJ · Epibatidine · in 13 records
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 9 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 9 records
- CLR · Cholesterol · in 6 records
- I34 · N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea · in 6 records
- I33 · 7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide · in 4 records
- IVM · (2ae,4e,5's,6s,6'r,7s,8e,11r,13r,15s,17ar,20r,20ar, 20BS)-6'-[(2S)-butan-2-yl]-20,20B-dihydroxy-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17A, 20,20A,20B-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside · in 2 records
- MAN · alpha-D-mannopyranose · in 2 records
- NCT · (S)-3-(1-methylpyrrolidin-2-yl)pyridine · in 2 records
- YLI · (3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide · in 2 records
- AZI · Azide ion · in 1 record
- BEZ · Benzoic acid · in 1 record
- R16 · Hexadecane · in 1 record
- XG3 · N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea · in 1 record
- YLR · (3aR,4S,9bS)-4-(naphthalen-1-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide · in 1 record
Experiment against prediction
- 8CE4 chain A against the predicted model P36544: TM-score 0.99, RMSD 0.64 Å
- 8CE4 chain C against the predicted model P36544: TM-score 0.99, RMSD 0.64 Å
- 8CE4 chain E against the predicted model P36544: TM-score 0.99, RMSD 0.65 Å
- 8CE4 chain B against the predicted model P36544: TM-score 0.99, RMSD 0.64 Å
- 8CE4 chain D against the predicted model P36544: TM-score 0.99, RMSD 0.65 Å
- 8CI1 chain D against the predicted model P36544: TM-score 0.98, RMSD 0.80 Å
- 8CI1 chain C against the predicted model P36544: TM-score 0.98, RMSD 0.80 Å
- 8CI1 chain E against the predicted model P36544: TM-score 0.98, RMSD 0.80 Å
- 8CI1 chain B against the predicted model P36544: TM-score 0.98, RMSD 0.80 Å
- 8CI1 chain A against the predicted model P36544: TM-score 0.98, RMSD 0.80 Å
Elsewhere
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