MolNFT v1 · #180091 · protein
Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and pnu- 120596 in the activated state
7KOX · Neuronal acetylcholine receptor subunit alpha-7,SOLUBLE…: “Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and pnu- 120596 in the activated state”. Electron microscopy, 3 ligands (EPJ, NAG, CA), 20 pockets (best…
- PDB
- 7KOX
- Type
- protein
- Length
- 1,930 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neuronal acetylcholine receptor subunit alpha-7,SOLUBLE cytochrome B562 fusion
- UniProt
- P36544
- Ligands
- EPJ, NAG, CA
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Neuronal acetylcholine receptor subunit alpha-7,SOLUBLE cytochrome B562 fusion | protein | 386 | 39% helix, 23% strand | P36544 |
Ligands and binding sites
- EPJ · Epibatidine · ligand · 5 copies · chains A, B, C, D, E
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 20 copies · chains A, B, C, D, E
- CA · Calcium ion · metal · 5 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 638 | 0.77 | 0.82 | 81 | CA |
| 2 | 445 | 0.76 | 0.84 | 38 | empty |
| 3 | 526 | 0.73 | 0.81 | 67 | CA |
| 4 | 70 | 0.72 | 0.96 | 16 | EPJ |
| 5 | 366 | 0.70 | 0.82 | 57 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2815 Ų buried · 26 hydrogen bonds · protein-protein
- A–E · 2804 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 2796 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 2788 Ų buried · 25 hydrogen bonds · protein-protein
- D–E · 2779 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 15 glycan, 10 disulfide (N-glycosylation, disulfide).
Compared structures
- 7KOX · Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and PNU-120596 in the… · the same entry in another collection · chain E against E, TM-score 1.00
- P36544 · AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit alpha-7… · a predicted model of the same protein · chain C against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36544
- Elsewhere: RCSB PDB 7KOX · PDBe 7KOX · UniProt P36544
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.