MolNFT v1 · #177514 · protein
Human alpha 7 nicotinic acetylcholine receptor bound to evp-6124 and pnu-120596
7EKT: “Human alpha 7 nicotinic acetylcholine receptor bound to evp-6124 and pnu-120596”. Electron microscopy, 4 ligands (CLR, I33, I34). MolNFT v1 #177514 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EKT
- Type
- protein
- Length
- 1,980 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P36544
- Ligands
- CLR, I33, I34, NAG
Structure
electron microscopy · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | — | protein | 396 | — | P36544 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 5 copies · chains A, B, C, D, E
- I33 · 7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide · ligand · 5 copies · chains A, E, B, C, D
- I34 · N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea · ligand · 5 copies · chains A, E, B, C, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 15 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EKT · human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596 · the same entry in another collection · chain E against E, TM-score 1.00
- P36544 · AlphaFold monomer V2.0 prediction for neuronal acetylcholine receptor subunit alpha-7… · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36544
- Elsewhere: RCSB PDB 7EKT · PDBe 7EKT · UniProt P36544
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