UniProt P36121
DNA-directed RNA polymerase III subunit RPC5 (P36121)
DNA-directed RNA polymerase III subunit RPC5 (UniProt P36121): 31 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P36121
- Protein
- DNA-directed RNA polymerase III subunit RPC5
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 38 · 12 records with a druggable one
Structures
32 records of P36121 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FJ8 | Cryo-EM structure of yeast RNA polymerase III elongation complex at 3. 9 A | electron microscopy | M | — | — |
| 5FJ8 | Cryo-EM structure of yeast RNA polymerase III elongation complex at 3. 9 a | electron microscopy | M | — | — |
| 5FJ9 | Cryo-EM structure of yeast apo RNA polymerase III at 4.6 A | electron microscopy | M | — | — |
| 5FJ9 | Cryo-EM structure of yeast apo RNA polymerase III at 4.6 a | electron microscopy | M | — | — |
| 5FJA | Cryo-EM structure of yeast RNA polymerase III at 4.7 A | electron microscopy | M | — | 3 (best 0.86) |
| 5FJA | Cryo-EM structure of yeast RNA polymerase III at 4.7 a | electron microscopy | M | — | — |
| 6CNB | Yeast RNA polymerase III initial transcribing complex | electron microscopy | M | — | — |
| 6CNC | Yeast RNA polymerase III open complex | electron microscopy | M | — | — |
| 6CND | Yeast RNA polymerase III natural open complex (noc) | electron microscopy | M | — | — |
| 6CNF | Yeast RNA polymerase III elongation complex | electron microscopy | M | — | — |
| 6EU0 | RNA polymerase III open pre-initiation complex (oc-pic) | electron microscopy | M | — | — |
| 6EU1 | RNA Polymerase III - open DNA complex (OC-POL3). | electron microscopy | M | — | — |
| 6EU1 | RNA polymerase III - open DNA complex (oc-POL3). | electron microscopy | M | — | — |
| 6EU2 | Apo RNA Polymerase III - open conformation (oPOL3) | electron microscopy | M | — | 3 (best 0.77) |
| 6EU2 | Apo RNA polymerase III - open conformation (OPOL3) | electron microscopy | M | — | — |
| 6EU3 | Apo RNA Polymerase III - closed conformation (cPOL3) | electron microscopy | M | — | 3 (best 0.76) |
| 6EU3 | Apo RNA polymerase III - closed conformation (CPOL3) | electron microscopy | M | — | — |
| 6F40 | RNA polymerase III open complex | electron microscopy | M | — | — |
| 6F41 | RNA Polymerase III initially transcribing complex | electron microscopy | M | — | 5 (best 0.80) |
| 6F41 | RNA polymerase III initially transcribing complex | electron microscopy | M | — | — |
| 6F42 | RNA Polymerase III closed complex CC1. | electron microscopy | M | — | 3 (best 0.80) |
| 6F42 | RNA polymerase III closed complex CC1. | electron microscopy | M | — | — |
| 6F44 | RNA Polymerase III closed complex CC2. | electron microscopy | M | — | 4 (best 0.81) |
| 6F44 | RNA polymerase III closed complex CC2. | electron microscopy | M | — | — |
| 6TUT | Cryo-EM structure of the RNA Polymerase III-Maf1 complex | electron microscopy | M | — | 2 (best 0.78) |
| 6TUT | Cryo-EM structure of the RNA polymerase III-MAF1 complex | electron microscopy | M | — | — |
| 7Z1L | Structure of yeast RNA Polymerase III Pre-Termination Complex (PTC) | electron microscopy | M | — | 3 (best 0.75) |
| 7Z1M | Structure of yeast RNA Polymerase III Elongation Complex (EC) | electron microscopy | M | — | 3 (best 0.77) |
| 7Z1O | Structure of yeast RNA Polymerase III PTC + NTPs | electron microscopy | M | — | 3 (best 0.74) |
| 7Z2Z | Structure of yeast RNA Polymerase III-DNA-Ty1 integrase complex (Pol III-DNA-IN1) at 3.1 A | electron microscopy | M | — | 2 (best 0.76) |
| 8BWS | Structure of yeast RNA Polymerase III elongation complex at 3.3 A | electron microscopy | M | 4QM | 3 (best 0.77) |
| P36121 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase III subunit RPC5 (P36121) | predicted | A | — | 1 (best 0.43) |
Ligands
- 4QM · (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-pentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7,12-triol · in 1 record
Experiment against prediction
- 6TUT chain M against the predicted model P36121: TM-score 0.93, RMSD 1.45 Å
- 6TUT chain M against the predicted model P36121: TM-score 0.93, RMSD 1.45 Å
- 7Z1M chain M against the predicted model P36121: TM-score 0.93, RMSD 1.70 Å
- 7Z1O chain M against the predicted model P36121: TM-score 0.92, RMSD 1.77 Å
- 7Z1L chain M against the predicted model P36121: TM-score 0.92, RMSD 1.79 Å
- 6F42 chain M against the predicted model P36121: TM-score 0.92, RMSD 1.48 Å
- 6F42 chain M against the predicted model P36121: TM-score 0.92, RMSD 1.48 Å
- 7Z2Z chain M against the predicted model P36121: TM-score 0.91, RMSD 1.71 Å
- 6F44 chain M against the predicted model P36121: TM-score 0.91, RMSD 1.74 Å
- 6F44 chain M against the predicted model P36121: TM-score 0.91, RMSD 1.74 Å
Elsewhere
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