UniProt P34943
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (P34943)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (UniProt P34943): 44 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 131 pockets. Binding sites, druggability and experiment…
- UniProt
- P34943
- Protein
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
- Experimental structures
- 44
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 131 · 34 records with a druggable one
Structures
45 records of P34943 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7DGQ | Activity optimized supercomplex state1 | electron microscopy | R | NAP | 1 (best 0.86) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | R | NAP | 2 (best 0.88) |
| 7DGZ | Activity optimized complex I (closed form) | electron microscopy | R | NAP | — |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | R | NAP | 2 (best 0.84) |
| 7DH0 | Activity optimized complex I (open form) | electron microscopy | R | NAP | — |
| 7DKF | Activity optimized supercomplex state4 | electron microscopy | R2 | NAP | 1 (best 0.84) |
| 7QSD | Bovine complex I in the active state at 3.1 A | electron microscopy | P | PC1, NDP | 4 (best 0.87) |
| 7QSD | Bovine complex I in the active state at 3.1 a | electron microscopy | P | PC1, NDP | — |
| 7QSK | Bovine complex I in lipid nanodisc, Active-Q10 | electron microscopy | P | PC1, CDL, NDP, 3PE | 3 (best 0.87) |
| 7QSK | Bovine complex I in lipid nanodisc, active-Q10 | electron microscopy | P | PC1, CDL, NDP, 3PE | — |
| 7QSL | Bovine complex I in lipid nanodisc, active-apo | electron microscopy | P | PC1, CDL, NDP, 3PE | — |
| 7QSM | Bovine complex I in lipid nanodisc, Deactive-ligand (composite) | electron microscopy | P | PC1, NDP | 4 (best 0.87) |
| 7QSM | Bovine complex I in lipid nanodisc, deactive-ligand (composite) | electron microscopy | P | PC1, NDP | — |
| 7QSN | Bovine complex I in lipid nanodisc, Deactive-apo | electron microscopy | P | PC1, NDP | 4 (best 0.88) |
| 7QSN | Bovine complex I in lipid nanodisc, deactive-apo | electron microscopy | P | PC1, NDP | — |
| 7QSO | Bovine complex I in lipid nanodisc, State 3 (Slack) | electron microscopy | P | PC1, NDP | — |
| 7QSO | Bovine complex I in lipid nanodisc, state 3 (slack) | electron microscopy | P | PC1, NDP | — |
| 7R41 | Bovine complex I in the presence of IM1761092, active class i (Composite map) | electron microscopy | P | PC1, CDL, NDP, 3PE | 4 (best 0.90) |
| 7R42 | Bovine complex I in the presence of IM1761092, active class ii (Composite map) | electron microscopy | P | PC1, CDL, NDP, 3PE | 5 (best 0.84) |
| 7R43 | Bovine complex I in the presence of IM1761092, active class iii (Composite map) | electron microscopy | P | PC1, CDL, NDP | — |
| 7R44 | Bovine complex I in the presence of IM1761092, active class iv (Composite map) | electron microscopy | P | PC1, CDL, NDP | 5 (best 0.87) |
| 7R45 | Bovine complex I in the presence of IM1761092, deactive class i (Composite map) | electron microscopy | P | NDP | 4 (best 0.87) |
| 7R46 | Bovine complex I in the presence of IM1761092, deactive class ii (Composite map) | electron microscopy | P | NDP | 4 (best 0.87) |
| 7R47 | Bovine complex I in the presence of IM1761092, deactive class iii (Composite map) | electron microscopy | P | NDP | — |
| 7R48 | Bovine complex I in the presence of IM1761092, deactive class iv (Composite map) | electron microscopy | P | NDP | 4 (best 0.88) |
| 7R4C | Bovine complex I in the presence of IM1761092, deactive class v (Composite map) | electron microscopy | P | NDP | 4 (best 0.86) |
| 7R4D | Bovine complex I in the presence of IM1761092, deactive class vi (Composite map) | electron microscopy | P | NDP | 4 (best 0.86) |
| 7R4F | Bovine complex I in the presence of IM1761092, slack class i (Composite map) | electron microscopy | P | PC1, NDP | 4 (best 0.86) |
| 7R4G | Bovine complex I in the presence of IM1761092, slack class ii (Composite map) | electron microscopy | P | NDP | 4 (best 0.87) |
| 8Q0A | Inward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | P | PC1, PLC, CDL, NDP, 3PE | 4 (best 0.87) |
| 8Q0F | Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | P | PC1, NDP | 4 (best 0.88) |
| 8Q0J | Inward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM. | electron microscopy | P | PC1, NDP | 3 (best 0.84) |
| 8Q0M | Outward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | P | PC1, CDL, NDP, 3PE, PLC | 5 (best 0.86) |
| 8Q0O | Outward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM. | electron microscopy | P | PC1, PLC, NDP | 4 (best 0.88) |
| 8Q0Q | Outward-facing, slack proteoliposome complex I at 3.6 A. Initially purified in DDM | electron microscopy | P | PC1, NDP | 4 (best 0.84) |
| 8Q1P | Inward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially… | electron microscopy | P | PC1, NDP | 4 (best 0.88) |
| 8Q1U | Inward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially… | electron microscopy | P | PC1, CDL, NDP | 4 (best 0.86) |
| 8Q1Y | Outward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially… | electron microscopy | P | PC1, PLC, NDP | 5 (best 0.86) |
| 8Q25 | Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially… | electron microscopy | P | PC1, CDL, NDP, 3PE | 5 (best 0.86) |
| 8Q46 | Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | P | PC1, NDP | 4 (best 0.88) |
| 8Q47 | Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG. | electron microscopy | P | PC1, CDL, NDP | 4 (best 0.87) |
| 8Q48 | Outward-facing, closed proteoliposome complex I at 2.5 A. Initially purified in LMNG. | electron microscopy | P | PC1, PLC, CDL, NDP, 3PE | 5 (best 0.86) |
| 8Q49 | Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | P | PC1, PLC, FVH | 4 (best 0.87) |
| 8Q4A | Outward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG. | electron microscopy | P | PC1, CDL, NDP, 3PE | 5 (best 0.86) |
| P34943 | AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9… | predicted | A | — | 4 (best 0.79) |
Ligands
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 37 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 31 records
- CDL · Cardiolipin · in 14 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 10 records
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 6 records
- PLC · Diundecyl phosphatidyl choline · in 6 records
- FVH · [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R}, 5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate · in 1 record
Experiment against prediction
- 7R41 chain P against the predicted model P34943: TM-score 1.00, RMSD 0.40 Å
- 7R43 chain P against the predicted model P34943: TM-score 1.00, RMSD 0.40 Å
- 7R44 chain P against the predicted model P34943: TM-score 1.00, RMSD 0.40 Å
- 7QSL chain P against the predicted model P34943: TM-score 1.00, RMSD 0.40 Å
- 7QSK chain P against the predicted model P34943: TM-score 1.00, RMSD 0.40 Å
- 7QSK chain P against the predicted model P34943: TM-score 1.00, RMSD 0.40 Å
- 7QSD chain P against the predicted model P34943: TM-score 1.00, RMSD 0.40 Å
- 7QSD chain P against the predicted model P34943: TM-score 1.00, RMSD 0.40 Å
- 7R42 chain P against the predicted model P34943: TM-score 1.00, RMSD 0.41 Å
- 7R4D chain P against the predicted model P34943: TM-score 1.00, RMSD 0.41 Å
Elsewhere
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