UniProt P32322
Pyrroline-5-carboxylate reductase 1, mitochondrial (P32322)
Pyrroline-5-carboxylate reductase 1, mitochondrial (UniProt P32322), EC 1.5.1.2: 32 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 127 pockets. Binding sites, druggability and experiment against…
- UniProt
- P32322
- Protein
- Pyrroline-5-carboxylate reductase 1, mitochondrial
- EC
- 1.5.1.2
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 127 · 11 records with a druggable one
Structures
33 records of P32322 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GER | Crystal Structure and Oxidative Mechanism of Human Pyrroline-5-carboxylate Reductase | x-ray diffraction | A, B, C, D, E | — | — |
| 2GER | Crystal structure and oxidative mechanism of human pyrroline-5- carboxylate reductase | x-ray diffraction | A, B, C, D, E | — | — |
| 2GR9 | Crystal structure of P5CR complexed with NADH | x-ray diffraction | A, B, C, D, E | — | — |
| 2GR9 | Crystal structure of P5CR complexed with NADH | x-ray diffraction | A, B, C, D, E | — | — |
| 2GRA | crystal structure of Human Pyrroline-5-carboxylate Reductase complexed with nadp | x-ray diffraction | A, B, C, D, E | — | — |
| 2GRA | Crystal structure of human pyrroline-5-carboxylate reductase complexed with NADP | x-ray diffraction | A, B, C, D, E | — | — |
| 2IZZ | Crystal structure of human pyrroline-5-carboxylate reductase | x-ray diffraction | A, B, C, D, E | — | — |
| 2IZZ | Crystal structure of human pyrroline-5-carboxylate reductase | x-ray diffraction | A, B, C, D, E | — | — |
| 5UAT | Structure of human PYCR-1 complexed with NADPH | x-ray diffraction | A, B, C, D, E | SO4, NDP | — |
| 5UAT | Structure of human pycr-1 complexed with NADPH | x-ray diffraction | A, B, C, D, E | SO4, NDP | — |
| 5UAU | Structure of human PYCR-1 complexed with proline | x-ray diffraction | A, B, C, D, E | SO4 | — |
| 5UAU | Structure of human pycr-1 complexed with proline | x-ray diffraction | A, B, C, D, E | SO4 | — |
| 5UAV | Structure of human PYCR-1 complexed with NADPH and L-tetrahydrofuroic acid | x-ray diffraction | A, B, C, D, E | NDP, TFB | — |
| 5UAV | Structure of human pycr-1 complexed with NADPH and L-tetrahydrofuroic acid | x-ray diffraction | A, B, C, D, E | NDP, TFB | — |
| 5UAW | Structure of apo human pycr-1 crystallized in space group P21212 | x-ray diffraction | A, B, C, D, E | SO4 | — |
| 5UAX | Structure of apo human PYCR-1 crystallized in space group C2 | x-ray diffraction | A, B, C, D, E | CL | — |
| 5UAX | Structure of apo human pycr-1 crystallized in space group C2 | x-ray diffraction | A, B, C, D, E | CL | — |
| 6XOZ | Structure of human PYCR1 complexed with L-tetrahydro-2-furoic acid | x-ray diffraction | A, B, C, D, E | TFB, CL | — |
| 6XP0 | Structure of human PYCR1 complexed with N-formyl L-proline | x-ray diffraction | A, B, C, D, E | — | — |
| 6XP1 | Structure of human PYCR1 complexed with L-thiazolidine-2-carboxylate | x-ray diffraction | A, B, C, D, E | T2C, SO4 | — |
| 6XP2 | Structure of human PYCR1 complexed with L-thiazolidine-4-carboxylate | x-ray diffraction | A, B, C, D, E | SO4 | — |
| 6XP3 | Structure of human PYCR1 complexed with cyclopentanecarboxylic acid | x-ray diffraction | A, B, C, D, E | SO4, IQ0 | — |
| 8TCV | Structure of PYCR1 complexed with 4-bromobenzene-1,3-dicarboxylic acid | x-ray diffraction | A, B, C, D, E | SO4, ZR0 | 11 (best 0.76) |
| 8TCW | Structure of PYCR1 complexed with 2-methyl-3-(2-oxoimidazolidin-1-yl)benzoic acid | x-ray diffraction | A, B, C, D, E | ZR6, SO4 | 12 (best 0.79) |
| 8TCY | Structure of PYCR1 complexed with 7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-carboxylic acid | x-ray diffraction | A, B, C, D, E | ZRE, SO4 | 11 (best 0.76) |
| 8TCZ | Structure of PYCR1 complexed with 2-(pyridin-2-yl)cyclopropane-1-carboxylic acid | x-ray diffraction | A, B, C, D, E | SO4, ZRI | 11 (best 0.75) |
| 8TD0 | Structure of PYCR1 complexed with 5-oxo-7a-phenyl-hexahydropyrrolo[2,1-b][1,3]thiazole-3-carboxylic… | x-ray diffraction | A, B, C, D, E | SO4, ZS5 | 12 (best 0.77) |
| 8TD1 | Structure of PYCR1 complexed with 3-(6-Oxa-9-azaspiro(4.5)decane-9-carbonyl)benzoic acid | x-ray diffraction | A, B, C, D, E | ZRZ, SO4 | 13 (best 0.76) |
| 8TD4 | Structure of PYCR1 complexed with NADH and 1,3-Dithiolane-2-carboxylic acid | x-ray diffraction | A, B, C, D, E | NAI, SO4, UJD | 14 (best 0.78) |
| 8TD6 | Structure of PYCR1 complexed with NADH and 2-(Methylthio)acetic acid | x-ray diffraction | A, B, C, D, E | NAI, MTG, SO4 | 11 (best 0.77) |
| 8TDC | Structure of PYCR1 complexed with NADH and 1,3-dithiane-2-carboxylic acid | x-ray diffraction | A, B, C, D, E | NAI, SO4, GIW | 14 (best 0.76) |
| 8VRE | Structure of PYCR1 complexed with NADH and N-formyl-L-proline | x-ray diffraction | A, B, C, D, E | NAI, FPK, SO4 | 14 (best 0.80) |
| P32322 | AlphaFold monomer V2.0 prediction for pyrroline-5-carboxylate reductase 1, mitochondrial (P32322) | predicted | A | — | 4 (best 0.56) |
Ligands
- SO4 · Sulfate ion · in 18 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 4 records
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 4 records
- CL · Chloride ion · in 3 records
- TFB · Tetrahydrofuran-2-carboxylic acid · in 3 records
- FPK · 1-formyl-L-proline · in 1 record
- GIW · 1,3-dithiane-2-carboxylic acid · in 1 record
- IQ0 · Cyclopentanecarboxylic acid · in 1 record
- MTG · [methylthio]acetate · in 1 record
- T2C · (2S)-1,3-thiazolidine-2-carboxylic acid · in 1 record
- UJD · 1,3-dithiolane-2-carboxylic acid · in 1 record
- ZR0 · 4-bromobenzene-1,3-dicarboxylic acid · in 1 record
- ZR6 · 2-methyl-3-(2-oxoimidazolidin-1-yl)benzoic acid · in 1 record
- ZRE · 7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-carboxylic acid · in 1 record
- ZRI · (1S,2S)-2-(pyridin-2-yl)cyclopropane-1-carboxylic acid · in 1 record
- ZRZ · 3-(6-oxa-9-azaspiro[4.5]decane-9-carbonyl)benzoic acid · in 1 record
- ZS5 · (3R,4S,7aR)-5-oxo-7a-phenylhexahydropyrrolo[2,1-b][1,3]thiazole-3-carboxylic acid · in 1 record
Experiment against prediction
- 2IZZ chain E against the predicted model P32322: TM-score 1.00, RMSD 0.33 Å
- 2IZZ chain E against the predicted model P32322: TM-score 1.00, RMSD 0.33 Å
- 8TD6 chain C against the predicted model P32322: TM-score 1.00, RMSD 0.35 Å
- 5UAX chain E against the predicted model P32322: TM-score 1.00, RMSD 0.34 Å
- 5UAX chain E against the predicted model P32322: TM-score 1.00, RMSD 0.34 Å
- 6XOZ chain E against the predicted model P32322: TM-score 1.00, RMSD 0.39 Å
- 6XP1 chain A against the predicted model P32322: TM-score 0.99, RMSD 0.43 Å
- 8TCZ chain C against the predicted model P32322: TM-score 0.99, RMSD 0.29 Å
- 5UAX chain D against the predicted model P32322: TM-score 0.99, RMSD 0.29 Å
- 5UAX chain D against the predicted model P32322: TM-score 0.99, RMSD 0.29 Å
Elsewhere
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