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Ligand · LHV

LHV · (2S)-2-hydroxy-3-methylbutanoic acid

LHV, (2S)-2-hydroxy-3-methylbutanoic acid (C5 H10 O3, 118.1 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
LHV
Formula
C5 H10 O3
Class
ligand
Structures
3
PDB entries
3

Binding sites

LHV in 3 structures; the first of them:

  • 8TD7 · Structure of PYCR1 complexed with 2S-hydroxy-3-methylbutyric acid · LHV A401 · binds VAL231, SER233, GLY236, ALA237, THR238, ALA97, MET121, THR171 and 2 more
  • 5EC1 · Kcsa with V76ESTER mutation · LHV C76 · binds GLU71, THR74, THR75, GLY77, TYR78
  • 5EC2 · Kcsa with V76ESTER+G77DA mutations · LHV C76 · binds GLU71, THR74, THR75, DAL77, TYR78

Residues it binds most

THR 7, GLY 6, SER 5, ALA 5, VAL 5, MET 4, GLU 2, TYR 2, DAL 1 (residue and the binding sites it lines).

Found with

  • DGA · Diacyl glycerol
  • F09 · Nonan-1-ol
  • K · Potassium ion
  • SO4 · Sulfate ion
  • PEG · Di(hydroxyethyl)ether

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