UniProt P32021
2-oxoglutarate-dependent ethylene/succinate-forming enzyme (P32021)
2-oxoglutarate-dependent ethylene/succinate-forming enzyme (UniProt P32021), EC 1.13.12.19, 1.14.11.34: 28 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 38 pockets. Binding sites, druggability and…
- UniProt
- P32021
- Protein
- 2-oxoglutarate-dependent ethylene/succinate-forming enzyme
- EC
- 1.13.12.19, 1.14.11.34, 1.14.20.7
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 38 · 6 records with a druggable one
Structures
29 records of P32021 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5LSQ | Ethylene Forming Enzyme from Pseudomonas syringae pv. phaseolicola - I222 crystal form | x-ray diffraction | A | MN, CL | — |
| 5LSQ | Ethylene forming enzyme from pseudomonas syringae pv. phaseolicola - I222 crystal form | x-ray diffraction | A | MN, CL | — |
| 5LUN | Ethylene Forming Enzyme from Pseudomonas syringae pv. phaseolicola - P1 ultra-high resolution… | x-ray diffraction | A, B, C, D | FE, OGA, ARG | 15 (best 0.76) |
| 5LUN | Ethylene forming enzyme from pseudomonas syringae pv. phaseolicola - P1 ultra-high resolution… | x-ray diffraction | A, B, C, D | FE, OGA | — |
| 5MOF | Ethylene forming enzyme from pseudomonas syringae pv. phaseolicola - I222 crystal form in complex… | x-ray diffraction | A | MN, CL, AKG | — |
| 5V2T | Ethylene forming enzyme in complex with manganese and tartrate | x-ray diffraction | A | MN | — |
| 5V2U | Ethylene forming enzyme apo form | x-ray diffraction | A | — | — |
| 5V2U | Ethylene forming enzyme apo form | x-ray diffraction | A | — | — |
| 5V2V | Ethylene forming enzyme in complex with nickel | x-ray diffraction | A | NI | 2 (best 0.63) |
| 5V2V | Ethylene forming enzyme in complex with nickel | x-ray diffraction | A | NI | — |
| 5V2X | Ethylene forming enzyme in complex with manganese and 2-oxoglutarate | x-ray diffraction | A, B | MN, AKG | — |
| 5V2X | Ethylene forming enzyme in complex with manganese and 2-oxoglutarate | x-ray diffraction | A, B | MN, AKG | — |
| 5V2Y | Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and L-arginine | x-ray diffraction | A | MN, ARG, AKG | 3 (best 0.73) |
| 5V2Y | Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and L-arginine | x-ray diffraction | A | MN, AKG | — |
| 5V2Z | Ethylene forming enzyme in complex with manganese, 2-oxoadipic acid and L-arginine | x-ray diffraction | A | MN, OOG, ARG | 3 (best 0.75) |
| 5V2Z | Ethylene forming enzyme in complex with manganese, 2-oxoadipic acid and L-arginine | x-ray diffraction | A | MN, OOG | — |
| 5V31 | Ethylene forming enzyme in complex with manganese and L-arginine | x-ray diffraction | A | MN | — |
| 5V32 | Ethylene forming enzyme in complex with manganese and malic acid | x-ray diffraction | A | MN, MLT | — |
| 5V34 | Ethylene forming enzyme in complex with manganese, malic acid and L- arginine | x-ray diffraction | A | MN, MLT | — |
| 5VKA | Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and N-omega-hydroxy-L-arginine | x-ray diffraction | A | MN, AKG | — |
| 5VKA | Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and N-omega-hydroxy-L-arginine | x-ray diffraction | A | MN, AKG | — |
| 5VKB | Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and argininamide | x-ray diffraction | A | MN, AKG | — |
| 6CBA | Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and canavanine | x-ray diffraction | A | MN, AKG | — |
| 6CF3 | Ethylene forming enzyme Y306A variant in complex with manganese and 2-oxoglutarate | x-ray diffraction | A | MN, AKG | 2 (best 0.71) |
| 6CF3 | Ethylene forming enzyme Y306A variant in complex with manganese and 2- oxoglutarate | x-ray diffraction | A | MN, AKG | — |
| 6VP4 | Ethylene forming enzyme (efe) in complex with FE(II), L-arginine, and 2OG | x-ray diffraction | A, B, C, D | FE, AKG | — |
| 6VP5 | Ethylene forming enzyme (EFE) D191E variant in complex with Fe(II), L-arginine, and 2OG | x-ray diffraction | A, B, C, D | FE, AKG, ARG | 13 (best 0.78) |
| 6VP5 | Ethylene forming enzyme (efe) D191E variant in complex with FE(II), L- arginine, and 2OG | x-ray diffraction | A, B, C, D | FE, AKG | — |
| P32021 | AlphaFold monomer V2.0 prediction for 2-oxoglutarate-dependent ETHYLENE/SUCCINATE-forming enzyme… | predicted | A | — | — |
Ligands
- MN · Manganese (II) ion · in 19 records
- AKG · 2-oxoglutaric acid · in 14 records
- FE · Fe (III) ion · in 5 records
- ARG · Arginine · in 4 records
- CL · Chloride ion · in 3 records
- MLT · D-malate · in 2 records
- NI · Nickel (II) ion · in 2 records
- OGA · N-oxalylglycine · in 2 records
- OOG · 2-oxoadipic acid · in 2 records
Experiment against prediction
- 5V2V chain A against the predicted model P32021: TM-score 0.99, RMSD 0.68 Å
- 5V2V chain A against the predicted model P32021: TM-score 0.99, RMSD 0.68 Å
- 6VP5 chain C against the predicted model P32021: TM-score 0.99, RMSD 0.71 Å
- 6VP5 chain D against the predicted model P32021: TM-score 0.99, RMSD 0.71 Å
- 5LUN chain B against the predicted model P32021: TM-score 0.99, RMSD 0.77 Å
- 5LUN chain A against the predicted model P32021: TM-score 0.99, RMSD 0.74 Å
- 6VP5 chain A against the predicted model P32021: TM-score 0.99, RMSD 0.81 Å
- 5LUN chain C against the predicted model P32021: TM-score 0.99, RMSD 0.81 Å
- 5V32 chain A against the predicted model P32021: TM-score 0.99, RMSD 0.81 Å
- 6VP5 chain C against the predicted model P32021: TM-score 0.99, RMSD 0.71 Å
Elsewhere
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