UniProt P31645
Sodium-dependent serotonin transporter (P31645)
Sodium-dependent serotonin transporter (UniProt P31645): 42 experimental structures on GenesisL1, 24 ligands bound, 89 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P31645
- Protein
- Sodium-dependent serotonin transporter
- Experimental structures
- 42
- Predicted models
- 0
- Ligands
- 24
- Pockets
- 89 · 10 records with a druggable one
Structures
42 records of P31645 in the MolNFT archive: 42 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5I6X | X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site | x-ray diffraction | A | NAG, CLR, 8PR, CL, NA | 9 (best 0.83) |
| 5I6X | X-ray structure of the TS3 human serotonin transporter complexed with paroxetine at the central site | x-ray diffraction | A | — | — |
| 5I6Z | X-ray structure of the ts2 human serotonin transporter | x-ray diffraction | A | NAG | 7 (best 0.83) |
| 5I6Z | X-ray structure of the TS2 human serotonin transporter | x-ray diffraction | A | — | — |
| 5I71 | X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central… | x-ray diffraction | A | 68P, NAG, CLR, D12, NA | 9 (best 0.84) |
| 5I71 | X-ray structure of the TS3 human serotonin transporter complexed with S-citalopram at the central… | x-ray diffraction | A | — | — |
| 5I73 | X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central… | x-ray diffraction | A | 68P, NAG, CLR, C14, NA, ACA | 9 (best 0.83) |
| 5I73 | X-ray structure of the TS3 human serotonin transporter complexed with S-citalopram at the central… | x-ray diffraction | A | — | — |
| 5I74 | X-ray structure of the ts3 human serotonin transporter complexed with Br-citalopram at the central… | x-ray diffraction | A | 69D, NAG, CLR, D12 | — |
| 5I74 | X-ray structure of the TS3 human serotonin transporter complexed with br-citalopram at the central… | x-ray diffraction | A | — | — |
| 5I75 | X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central… | x-ray diffraction | A | 68P, NAG, CLR, C14, 69D, NA | — |
| 5I75 | X-ray structure of the TS3 human serotonin transporter complexed with S-citalopram at the central… | x-ray diffraction | A | — | — |
| 6AWN | X-ray structure of the S439T human serotonin transporter complexed with paroxetine at the central… | x-ray diffraction | A | NAG, CLR, 8PR, CL, NA | — |
| 6AWO | X-ray structure of the TS3 human serotonin transporter complexed with sertraline at the central site | x-ray diffraction | A | SRE, NAG, CLR, CL, NA | — |
| 6AWP | X-ray structure of the TS3 human serotonin transporter complexed with fluvoxamine at the central… | x-ray diffraction | A | FVX, NAG, CLR, CL, NA | — |
| 6AWQ | Anomalous chloride signal reveals the position of sertraline complexed with the serotonin… | x-ray diffraction | A | SRE, NAG, CLR, CL, NA | — |
| 6DZV | Wild type human serotonin transporter in complex with 15B8 Fab bound to ibogaine in occluded… | electron microscopy | A | NAG, HJM, Y01 | 12 (best 0.82) |
| 6DZV | Wild type human serotonin transporter in complex with 15B8 Fab bound to ibogaine in occluded… | electron microscopy | A | NAG, HJM, Y01 | — |
| 6DZW | Cryo-EM structure of the ts2-inactive human serotonin transporter in complex with paroxetine and… | electron microscopy | A | NAG, 8PR | 12 (best 0.87) |
| 6DZW | Cryo-EM structure of the TS2-inactive human serotonin transporter in complex with paroxetine and… | electron microscopy | A | NAG, 8PR | — |
| 6DZY | Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6… | electron microscopy | A | NAG, HJM | — |
| 6DZY | Cryo-EM structure of the TS2-active human serotonin transporter in complex with 15B8 Fab and 8B6… | electron microscopy | A | NAG, HJM | — |
| 6DZZ | Cryo-EM Structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8… | electron microscopy | A | NAG, HJM | — |
| 6DZZ | Cryo-EM structure of the wild-type human serotonin transporter in complex with ibogaine and 15B8… | electron microscopy | A | NAG, HJM | — |
| 6VRH | Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab | electron microscopy | A | NAG, 8PR, CL | — |
| 6VRK | Cryo-EM structure of the wild-type human serotonin transporter complexed with br-paroxetine and 8B6… | electron microscopy | A | NAG, RFS | — |
| 6VRL | Cryo-EM structure of the wild-type human serotonin transporter complexed with I-paroxetine and 8B6… | electron microscopy | A | NAG, RFY | — |
| 6W2B | Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin… | x-ray diffraction | A | NAG, RFS | 7 (best 0.85) |
| 6W2B | Anomalous bromine signal reveals the position of br-paroxetine complexed with the serotonin… | x-ray diffraction | A | NAG, RFS | — |
| 6W2C | Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin… | x-ray diffraction | A | RFY | — |
| 7LI6 | Apo sert reconstituted in lipid nanodisc in kcl | electron microscopy | A | NAG, CL, R16, HP6, D10, D12 | — |
| 7LI7 | Apo serotonin transporter reconstituted in lipid nanodisc in presence of nacl in occluded… | electron microscopy | A | NAG, D12, HP6, LNK, CLR, D10 | — |
| 7LI8 | apo serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in inward open… | electron microscopy | A | NAG, R16, D10, D12, HP6, LNK | — |
| 7LI8 | Apo serotonin transporter reconstituted in lipid nanodisc in presence of nacl in inward open… | electron microscopy | A | NAG, R16, D10, D12, HP6, LNK | — |
| 7LI9 | 5-ht bound serotonin transporter reconstituted in lipid nanodisc in kcl | electron microscopy | A | NAG, D12, HP6, D10, LNK, SRO | — |
| 7LIA | 5-HT bound serotonin transporter reconstituted in lipid nanodisc in presence of NaCl in outward… | electron microscopy | A | NAG, SRO, CL, NA, D10, HP6 | 7 (best 0.77) |
| 7LIA | 5-ht bound serotonin transporter reconstituted in lipid nanodisc in presence of nacl in outward… | electron microscopy | A | NAG, SRO, CL, NA, D10, HP6 | — |
| 7LWD | Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone… | electron microscopy | A | IXX, YG7, NAG | — |
| 7MGW | 5-HT bound serotonin transporter reconstituted in lipid nanodisc in NaCl in occluded conformation | electron microscopy | A | NAG, CL, D12, LNK, HP6, D10 | 11 (best 0.73) |
| 7MGW | 5-ht bound serotonin transporter reconstituted in lipid nanodisc in nacl in occluded conformation | electron microscopy | A | NAG, CL, D12, D10, HP6, SRO | — |
| 7TXT | Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl | electron microscopy | S | KWC | 6 (best 0.80) |
| P31645 | AlphaFold monomer V2.0 prediction for sodium-dependent serotonin transporter (P31645) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 33 records
- CLR · Cholesterol · in 14 records
- CL · Chloride ion · in 12 records
- NA · Sodium ion · in 10 records
- D10 · Decane · in 9 records
- D12 · Dodecane · in 9 records
- HP6 · Heptane · in 9 records
- LNK · Pentane · in 8 records
- HJM · (5beta)-12-methoxyibogamine · in 6 records
- 8PR · Paroxetine · in 5 records
- SRO · Serotonin · in 5 records
- 68P · (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile · in 3 records
- R16 · Hexadecane · in 3 records
- RFS · Br-paroxetine · in 3 records
- 69D · (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile · in 2 records
- C14 · Tetradecane · in 2 records
- RFY · I-paroxetine · in 2 records
- SRE · (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine · in 2 records
- Y01 · Cholesterol hemisuccinate · in 2 records
- ACA · 6-aminohexanoic acid · in 1 record
- FVX · Fluvoxamine · in 1 record
- IXX · 3-(5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine · in 1 record
- KWC · 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine · in 1 record
- YG7 · 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide · in 1 record
Elsewhere
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