MolNFT v1 · #143340 · protein
X-ray structure of the TS3 human serotonin transporter complexed with fluvoxamine at the central site
6AWP: “X-ray structure of the TS3 human serotonin transporter complexed with fluvoxamine at the central site”. X-ray diffraction, 5 ligands (FVX, CLR, NAG). MolNFT v1 #143340 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6AWP
- Type
- protein
- Length
- 976 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P31645, A0A0F7R1P3, A0A0F7R5U8
- Ligands
- FVX, CLR, NAG, NA, CL
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 544 | — | P31645 |
| B | — | protein | 218 | — | A0A0F7R1P3 |
| C | — | protein | 214 | — | A0A0F7R5U8 |
Ligands and binding sites
- FVX · Fluvoxamine · ligand · chains A
- CLR · Cholesterol · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
- NA · Sodium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6AWP · X-ray structure of the ts3 human serotonin transporter complexed with fluvoxamine at the… · the same entry in another collection · chain A against A, TM-score 1.00
- P31645 · AlphaFold monomer V2.0 prediction for sodium-dependent serotonin transporter (P31645) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31645
- Every structure of UniProt A0A0F7R1P3
- Every structure of UniProt A0A0F7R5U8
- Elsewhere: RCSB PDB 6AWP · PDBe 6AWP · UniProt P31645 · UniProt A0A0F7R1P3 · UniProt A0A0F7R5U8
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