MolNFT v1 · #167658 · protein

Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab

6VRH: “Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab”. Electron microscopy, 3 ligands (8PR, NAG, CL). MolNFT v1 #167658 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6VRH
Type: protein
Length: 764 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P31645, A0A0U5BC76
Ligands: 8PR, NAG, CL

Structure

electron microscopy · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	541	—	P31645
C	—	protein	106	—	A0A0U5BC76
B	—	protein	117	—	—

Ligands and binding sites

8PR · Paroxetine · ligand · chains A
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, C
CL · Chloride ion · ion · chains A
LMT · Dodecyl-beta-D-maltoside · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6VRH · Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine… · the same entry in another collection · chain A against A, TM-score 1.00
P31645 · AlphaFold monomer V2.0 prediction for sodium-dependent serotonin transporter (P31645) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31645
Every structure of UniProt A0A0U5BC76
Elsewhere: RCSB PDB 6VRH · PDBe 6VRH · UniProt P31645 · UniProt A0A0U5BC76

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