UniProt P30613
Pyruvate kinase PKLR (P30613)
Pyruvate kinase PKLR (UniProt P30613), EC 2.7.1.40: 36 experimental structures on GenesisL1, 26 ligands bound, 360 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P30613
- Protein
- Pyruvate kinase PKLR
- EC
- 2.7.1.40
- Experimental structures
- 36
- Predicted models
- 0
- Ligands
- 26
- Pockets
- 360 · 18 records with a druggable one
Structures
36 records of P30613 in the MolNFT archive: 36 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VGB | Human erythrocyte pyruvate kinase | x-ray diffraction | A, B, C, D | — | — |
| 2VGB | Human erythrocyte pyruvate kinase | x-ray diffraction | A, B, C, D | — | — |
| 2VGF | HUMAN ERYTHROCYTE PYRUVATE KINASE: T384M mutant | x-ray diffraction | A, B, C, D | — | — |
| 2VGF | Human erythrocyte pyruvate kinase: T384M mutant | x-ray diffraction | A, B, C, D | — | — |
| 2VGG | Human erythrocyte pyruvate kinase: R479H mutant | x-ray diffraction | A, B, C, D | — | — |
| 2VGG | Human erythrocyte pyruvate kinase: R479H mutant | x-ray diffraction | A, B, C, D | — | — |
| 2VGI | Human erythrocyte pyruvate kinase: R486W mutant | x-ray diffraction | A, B, C, D | — | — |
| 2VGI | Human erythrocyte pyruvate kinase: R486W mutant | x-ray diffraction | A, B, C, D | — | — |
| 4IP7 | Structure of the S12D variant of human liver pyruvate kinase in complex with citrate and FBP. | x-ray diffraction | A, B, C, D | — | — |
| 4IP7 | Structure of the S12D variant of human liver pyruvate kinase in complex with citrate and fbp. | x-ray diffraction | A, B, C, D | — | — |
| 6NN4 | The structure of human liver pyruvate kinase, hlpyk-D499N, in complex with fru-1,6-bp | x-ray diffraction | A, B, C, D | FBP, PEP | — |
| 6NN5 | The structure of human liver pyruvate kinase, hlpyk-W527H | x-ray diffraction | A, B, C, D | — | — |
| 6NN7 | The structure of human liver pyruvate kinase, hLPYK-GGG | x-ray diffraction | A, B, C, E, D, F, G, H | — | 20 (best 0.87) |
| 6NN7 | The structure of human liver pyruvate kinase, hlpyk-ggg | x-ray diffraction | A, B, C, E, D, F, G, H | — | — |
| 6NN8 | The structure of human liver pyruvate kinase, hLPYK-S531E | x-ray diffraction | A, B, C, D, E, F, G, H | — | 20 (best 0.88) |
| 6NN8 | The structure of human liver pyruvate kinase, hlpyk-S531E | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 7FRV | Structure of liver pyruvate kinase in complex with allosteric modulator 3 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, OD5 | — |
| 7FRW | Structure of liver pyruvate kinase in complex with allosteric modulator 4 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, OA0 | 20 (best 0.88) |
| 7FRX | Structure of liver pyruvate kinase in complex with allosteric modulator 5 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, O88 | 20 (best 0.87) |
| 7FRY | Structure of liver pyruvate kinase in complex with allosteric modulator 6 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, Y0T | 20 (best 0.88) |
| 7FRZ | Structure of liver pyruvate kinase in complex with allosteric modulator 7 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, O99 | 20 (best 0.87) |
| 7FS0 | Structure of liver pyruvate kinase in complex with allosteric modulator 8 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, O8X | 20 (best 0.87) |
| 7FS1 | Structure of liver pyruvate kinase in complex with allosteric modulator 11 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, O8F | 20 (best 0.87) |
| 7FS2 | Structure of liver pyruvate kinase in complex with allosteric modulator 13 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, O7X | 20 (best 0.87) |
| 7FS3 | Structure of liver pyruvate kinase in complex with allosteric modulator 15 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, O9I | 20 (best 0.88) |
| 7FS4 | Structure of liver pyruvate kinase in complex with allosteric modulator 16 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, O9R | 20 (best 0.88) |
| 7FS5 | Structure of liver pyruvate kinase in complex with allosteric modulator 17 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, O8O | 20 (best 0.87) |
| 7FS6 | Structure of liver pyruvate kinase in complex with allosteric modulator 18 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, Y3Z | 20 (best 0.88) |
| 7FS9 | Structure of liver pyruvate kinase in complex with allosteric modulator 22 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, OB0 | 20 (best 0.87) |
| 7FSB | Structure of liver pyruvate kinase in complex with allosteric modulator 41 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, OE0 | — |
| 7FSC | Structure of liver pyruvate kinase in complex with allosteric modulator 42 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXL, MG, K, ODL | 20 (best 0.87) |
| 7QDN | Structure of human liver pyruvate kinase from which the B domain has been deleted | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXD, MG, K, NA | 20 (best 0.87) |
| 7QDN | Structure of human liver pyruvate kinase from which the B domain has been deleted | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, OXD, MG, K, NA | — |
| 8TBS | Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator AG-946 | x-ray diffraction | A, B, C, D, E, F, G, H | FBP, MN, K, PYR, HVI | 20 (best 0.89) |
| 8TBU | Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator Compound 12 | x-ray diffraction | A, B, C, D, E, F, G, H | I0R, PYR, FBP, MN, K | 20 (best 0.89) |
| P30613 | AlphaFold monomer V2.0 prediction for pyruvate kinase pklr (P30613) | — | — | — |
Ligands
- FBP · 1,6-di-O-phosphono-beta-D-fructofuranose · in 20 records
- K · Potassium ion · in 19 records
- MG · Magnesium ion · in 17 records
- OXL · Oxalate ion · in 15 records
- MN · Manganese (II) ion · in 2 records
- NA · Sodium ion · in 2 records
- OXD · Oxalic acid · in 2 records
- PYR · Pyruvic acid · in 2 records
- HVI · 6-[(6-aminopyridin-2-yl)methyl]-4-methyl-2-[(1H-pyrazol-3-yl)methyl]-4,6-dihydro-5H-[1,3]thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one · in 1 record
- I0R · 6-[(4-hydroxyphenyl)methyl]-2,4-dimethyl-4,6-dihydro-5H-[1,3]thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one · in 1 record
- O7X · (1P)-3',4,4',5-tetrahydroxy-N-{[4-(3-hydroxybenzene-1-sulfonyl)phenyl]methyl}[1,1'-biphenyl]-2-sulfonamide · in 1 record
- O88 · N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-3,4-dihydroxybenzene-1-sulfonamide · in 1 record
- O8F · (1P)-N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-3',4,4',5-tetrahydroxy[1,1'-biphenyl]-2-sulfonamide · in 1 record
- O8O · (10aP)-6-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-2,3,8,9-tetrahydroxy-5lambda~6~-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione · in 1 record
- O8X · 3,4-dihydroxy-N-{2-[4-(3-hydroxybenzene-1-sulfonyl)phenyl]ethyl}benzene-1-sulfonamide · in 1 record
- O99 · 3,4-dihydroxy-N-{[4-(3-hydroxybenzene-1-sulfonyl)phenyl]methyl}benzene-1-sulfonamide · in 1 record
- O9I · N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-4,4',5-trihydroxy[1,1'-biphenyl]-2-sulfonamide · in 1 record
- O9R · 4,4',5-trihydroxy-N-{[4-(3-hydroxybenzene-1-sulfonyl)phenyl]methyl}[1,1'-biphenyl]-2-sulfonamide · in 1 record
- OA0 · (10aM)-3,8,9-trihydroxy-6H-6lambda~6~-dibenzo[c,e][1,2]oxathiine-6,6-dione · in 1 record
- OB0 · 4-[4-(4-aminobenzene-1-sulfonyl)piperazine-1-sulfonyl]benzene-1,2-diol · in 1 record
- OD5 · 4,4'-sulfonyldi(benzene-1,2-diol) · in 1 record
- ODL · N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)benzenesulfonamide · in 1 record
- OE0 · N-({4-[(3,4-dihydroxyphenyl)methyl]phenyl}methyl)-3,4-dihydroxybenzene-1-sulfonamide · in 1 record
- PEP · Phosphoenolpyruvate · in 1 record
- Y0T · N-{2-[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]ethyl}-3,4-dihydroxybenzene-1-sulfonamide · in 1 record
- Y3Z · (10aM)-6-{2-[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]ethyl}-2,3,8,9-tetrahydroxy-5lambda~6~-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione · in 1 record
Elsewhere
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