Ligand · HVI

HVI · 6-[(6-aminopyridin-2-yl)methyl]-4-methyl-2-[(1H-pyrazol-3-yl)methyl]-4,6-dihydro-5H-[1,3]thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one

HVI, 6-[(6-aminopyridin-2-yl)methyl]-4-methyl-2-[(1H-pyrazol-3-yl)methyl]-4,6-dihydro-5H-[1,3]thiazolo[5',4':4,5]pyrrolo[2,3-d]pyridazin-5-one (C18 H16 N8 O S, 392.4 g/mol), in the MolNFT structures on GenesisL1: bound in 1 record (1 PDB…

Component: HVI
Formula: C18 H16 N8 O S
Class: ligand
Structures: 1
PDB entries: 1

Binding sites

HVI in 1 structure; the first of them:

8TBS · Structure of human erythrocyte pyruvate kinase in complex with an allosteric activator… · HVI B601 · binds PHE69, LEU70, LEU73, LEU396, ASP397, TYR433, GLN436, LEU437 and 12 more

Residues it binds most

LEU 4, GLN 4, GLU 4, PHE 4, TYR 4, ASP 4, ASN 4, GLY 4 (residue and the binding sites it lines).

Found with

FBP · 1,6-di-O-phosphono-beta-D-fructofuranose
PYR · Pyruvic acid
K · Potassium ion
MN · Manganese (II) ion

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