MolNFT v2 · #181103 · protein

Structure of liver pyruvate kinase in complex with allosteric modulator 3

7FRV: “Structure of liver pyruvate kinase in complex with allosteric modulator 3”. X-ray diffraction at 2.004, 5 ligands (OXL, OD5, FBP). MolNFT v2 #181103 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7FRV
Type: protein
Length: 3,405 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.004
Source: Homo sapiens
UniProt: P30613
Ligands: OXL, OD5, FBP, MG, K

Structure

x-ray diffraction · resolution 2.004 · 7 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	422	—	P30613
B	—	protein	436	—	P30613
C	—	protein	425	—	P30613
D, H	—	protein	425	—	P30613
E	—	protein	419	—	P30613
F	—	protein	432	—	P30613
G	—	protein	421	—	P30613

Ligands and binding sites

OXL · Oxalate ion · ligand · 8 copies · chains A, B, C, D, E, F, G, H
OD5 · 4,4'-sulfonyldi(benzene-1,2-diol) · ligand · 4 copies · chains A, C, B, D, F, H, E, G
FBP · 1,6-di-O-phosphono-beta-D-fructofuranose · sugar · 8 copies · chains A, B, C, G, D, E, F, H
MG · Magnesium ion · metal · 8 copies · chains A, B, C, D, E, F, G, H
K · Potassium ion · metal · 8 copies · chains A, B, C, D, E, F, G, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

P30613 · AlphaFold monomer V2.0 prediction for pyruvate kinase pklr (P30613) · a predicted model of the same protein · chain G against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30613
Elsewhere: RCSB PDB 7FRV · PDBe 7FRV · UniProt P30613

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