UniProt P29597
Non-receptor tyrosine-protein kinase TYK2 (P29597)
Non-receptor tyrosine-protein kinase TYK2 (UniProt P29597), EC 2.7.10.2: 81 experimental structures on GenesisL1, 39 ligands bound, 61 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P29597
- Protein
- Non-receptor tyrosine-protein kinase TYK2
- EC
- 2.7.10.2
- Experimental structures
- 81
- Predicted models
- 0
- Ligands
- 39
- Pockets
- 61 · 13 records with a druggable one
Structures
81 records of P29597 in the MolNFT archive: 81 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3LXN | Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with… | x-ray diffraction | A | — | — |
| 3LXN | Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with… | x-ray diffraction | A | — | — |
| 3LXP | Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with… | x-ray diffraction | A | — | — |
| 3LXP | Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with… | x-ray diffraction | A | — | — |
| 3NYX | Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor | x-ray diffraction | A | — | — |
| 3NYX | Non-phosphorylated TYK2 JH1 domain with quinoline-thiadiazole- thiophene inhibitor | x-ray diffraction | A | — | — |
| 3NZ0 | Non-phosphorylated TYK2 kinase with CMP6 | x-ray diffraction | A | — | — |
| 3NZ0 | Non-phosphorylated TYK2 kinase with CMP6 | x-ray diffraction | A | — | — |
| 3ZON | Human TYK2 pseudokinase domain bound to a kinase inhibitor | x-ray diffraction | A | — | — |
| 3ZON | Human TYK2 pseudokinase domain bound to a kinase inhibitor | x-ray diffraction | A | — | — |
| 4GFO | TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE | x-ray diffraction | A | — | — |
| 4GFO | TYK2 kinase (JH1 domain) with 2,6-dichloro-N-(2-oxo-2,5- dihydropyridin-4-YL)BENZAMIDE | x-ray diffraction | A | — | — |
| 4GIH | Tyk2 (JH1) in complex with 2,6-DICHLORO-N-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}BENZAMIDE | x-ray diffraction | A | — | — |
| 4GIH | TYK2 (JH1) in complex with 2,6-dichloro-N-{2-[(cyclopropylcarbonyl) AMINO]PYRIDIN-4-YL}BENZAMIDE | x-ray diffraction | A | — | — |
| 4GII | Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzam… | x-ray diffraction | A | — | — |
| 4GII | TYK2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2… | x-ray diffraction | A | — | — |
| 4GJ2 | Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4… | x-ray diffraction | A | — | — |
| 4GJ2 | TYK2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2… | x-ray diffraction | A | — | — |
| 4GJ3 | Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)p… | x-ray diffraction | A | — | — |
| 4GJ3 | TYK2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2… | x-ray diffraction | A | — | — |
| 4GVJ | Tyk2 (JH1) in complex with adenosine di-phosphate | x-ray diffraction | A | — | — |
| 4GVJ | TYK2 (JH1) in complex with adenosine di-phosphate | x-ray diffraction | A | — | — |
| 4OLI | The pseudokinase/kinase protein from JAK-family member TYK2 | x-ray diffraction | A | — | — |
| 4OLI | The PSEUDOKINASE/KINASE protein from JAK-family member TYK2 | x-ray diffraction | A | — | — |
| 4PO6 | Crystal structure of the human TYK2 FERM and SH2 domains with an IFNAR1 intracellular peptide | x-ray diffraction | A | — | — |
| 4PO6 | Crystal structure of the human TYK2 ferm and SH2 domains with an IFNAR1 intracellular peptide | x-ray diffraction | A | — | — |
| 4PY1 | Crystal structure of Tyk2 in complex with compound 15… | x-ray diffraction | A | — | — |
| 4PY1 | Crystal structure of TYK2 in complex with compound 15, 6-((2,5… | x-ray diffraction | A | — | — |
| 4WOV | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with bms-066 aka… | x-ray diffraction | A, B | 3SM, SO4 | 7 (best 0.68) |
| 4WOV | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with bms-066 aka… | x-ray diffraction | A, B | — | — |
| 5C01 | Crystal Structure of kinase | x-ray diffraction | A, B | — | — |
| 5C01 | Crystal structure of kinase | x-ray diffraction | A, B | — | — |
| 5C03 | Crystal Structure of kinase | x-ray diffraction | A, B | AGS, MG | 5 (best 0.67) |
| 5C03 | Crystal structure of kinase | x-ray diffraction | A, B | — | — |
| 5F1Z | Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidan… | x-ray diffraction | A | 5U3 | 3 (best 0.68) |
| 5F1Z | Structure of TYK2 with inhibitor 16: 3-azanyl-5-[(2~{S})-3… | x-ray diffraction | A | — | — |
| 5F20 | Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1… | x-ray diffraction | A | — | — |
| 5TKD | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with… | x-ray diffraction | A, B | 7GL, SO4 | — |
| 5WAL | Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that… | x-ray diffraction | A | 9ZS | — |
| 5WAL | Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that… | x-ray diffraction | A | 9ZS | — |
| 6AAM | Crystal structure of TYK2 in complex with peficitinib | x-ray diffraction | A | 9T6 | — |
| 6DBK | Tyk2 with compound 8 | x-ray diffraction | A | G5D | 3 (best 0.63) |
| 6DBK | TYK2 with compound 8 | x-ray diffraction | A | G5D | — |
| 6DBM | Tyk2 with compound 23 | x-ray diffraction | A | G4J | — |
| 6DBM | TYK2 with compound 23 | x-ray diffraction | A | G4J | — |
| 6NSL | CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound-6c AKA… | x-ray diffraction | A, B | KZJ, SO4 | 4 (best 0.69) |
| 6NSL | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with compound-6C aka… | x-ray diffraction | A, B | KZJ, SO4 | — |
| 6NZE | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with COMPOUND_5 aka… | x-ray diffraction | A, B | L8Y, SO4 | — |
| 6NZF | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with COMPOUND_5 aka… | x-ray diffraction | A, B | L91, SO4 | — |
| 6NZH | CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_40 AKA… | x-ray diffraction | A, B | L9A | — |
| 6NZH | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with COMPOUND_40 aka… | x-ray diffraction | A, B | L9A | — |
| 6NZP | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with compound-11 aka… | x-ray diffraction | A, B | LB7, CL | — |
| 6NZP | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with compound-11 aka… | x-ray diffraction | A, B | LB7, CL | — |
| 6NZQ | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with COMPOUND_29 aka… | x-ray diffraction | A, B | LB4 | — |
| 6NZR | Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with COMPOUND_12 aka… | x-ray diffraction | A, B | LAJ, SO4 | — |
| 6OVA | Crystal structure of TYK2 with novel pyrrolidinone inhibitor | x-ray diffraction | A | N9G | — |
| 6VNS | Crystal structure of TYK2 kinase with compound 13 | x-ray diffraction | A | R5D | 1 (best 0.73) |
| 6VNS | Crystal structure of TYK2 kinase with compound 13 | x-ray diffraction | A | R5D | — |
| 6VNV | Crystal structure of TYK2 kinase with compound 14 | x-ray diffraction | A | R4Y | — |
| 6VNX | Crystal structure of TYK2 kinase with compound 19 | x-ray diffraction | A | R4V | 1 (best 0.73) |
21 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 9 records
- 9ZS · N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide · in 2 records
- CL · Chloride ion · in 2 records
- G4J · [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone · in 2 records
- G5D · 4-({4-[(1S,4S)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-N-ethylbenzamide · in 2 records
- KZJ · 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-N-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide · in 2 records
- L9A · 6-[(cyclopropanecarbonyl)amino]-N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide · in 2 records
- LB7 · 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide · in 2 records
- OV0 · 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl) anilino]-5H-pyrrolo[3,4-b]pyridin-5-one · in 2 records
- OV5 · 6-{[(2M)-2-(2-chloro-6-fluorophenyl)-5-oxo-5H-pyrrolo[3,4-b]pyridin-4-yl]amino}-N-ethylpyridine-3-carboxamide · in 2 records
- R4V · (1S)-2,2-difluoro-N-[(1S,5R,6R)-3-{5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-6-methyl-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide · in 2 records
- R5D · (1R,2R)-2-cyano-N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide · in 2 records
- 3SM · 2-methoxy-N-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide · in 1 record
- 5U3 · 3-azanyl-5-[(2~{S})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{H}-pyrazolo[4,3-c]pyridin-4-one · in 1 record
- 7GL · 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1, 2-b]pyridazine-3-carboxamide · in 1 record
- 9T6 · 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2, 3-b]pyridine-5-carboxamide · in 1 record
- AGS · Phosphothiophosphoric acid-adenylate ester · in 1 record
- CA · Calcium ion · in 1 record
- L8Y · 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl) amino]-N-methylpyridine-3-carboxamide · in 1 record
- L91 · 6-[(5-fluoropyridin-2-yl)amino]-N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide · in 1 record
- LAJ · N-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide · in 1 record
- LB4 · 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-N-methylpyridine-3-carboxamide · in 1 record
- MG · Magnesium ion · in 1 record
- N9G · 6-({4-[(3S)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-N,N-dimethylpyridine-3-carboxamide · in 1 record
- NM7 · 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide · in 1 record
- OVC · 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5H-pyrrolo[3,4-d]pyrimidin-5-one · in 1 record
- OVI · 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5H-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-N-ethylacetamide · in 1 record
- PO4 · Phosphate ion · in 1 record
- R4S · N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide · in 1 record
- R4Y · (1S,2S)-2-cyano-N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide · in 1 record
Elsewhere
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