GL1X · GenesisL1 explorer

Ligand · 0X2

0X2 · 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide

0X2, 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide (C12 H8 Cl2 N2 O2, 283.1 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
0X2
Formula
C12 H8 Cl2 N2 O2
Class
ligand
Structures
4
PDB entries
2

Binding sites

0X2 in 4 structures; the first of them:

  • 4GFM · JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE · 0X2 A1201 · binds LEU855, GLY856, LYS857, GLY858, VAL863, ALA880, VAL911, MET929 and 8 more
  • 4GFO · TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE · 0X2 A1206 · binds LEU903, GLY904, GLU905, GLY906, VAL911, ALA928, ILE960, MET978 and 8 more
  • 4GFM · JAK2 kinase (JH1 domain) with 2,6-dichloro-N-(2-oxo-2,5- dihydropyridin-4-YL)BENZAMIDE · 0X2 A1201 · binds LEU855, GLY856, LYS857, GLY858, VAL863, ALA880, VAL911, MET929 and 8 more
  • 4GFO · TYK2 kinase (JH1 domain) with 2,6-dichloro-N-(2-oxo-2,5- dihydropyridin-4-YL)BENZAMIDE · 0X2 A1206 · binds LEU903, GLY904, GLU905, GLY906, VAL911, ALA928, ILE960, MET978 and 8 more

Residues it binds most

GLY 4, LEU 4, VAL 4, GLU 4, ALA 4, ARG 4, ASN 4, ASP 4, MET 4, TYR 4 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol
  • GOL · Glycerol

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