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Ligand · KZJ

KZJ · 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-N-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide

KZJ, 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-N-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide (C23 H20 N8 O2, 440.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
KZJ
Formula
C23 H20 N8 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

KZJ in 2 structures; the first of them:

  • 6NSL · CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH… · KZJ A901 · binds LEU595, GLY596, GLN597, VAL603, VAL640, LYS642, THR687, GLU688 and 11 more
  • 6NSL · Crystal structure of tyrosine kinase 2 JH2 (pseudo kinase domain) complexed with… · KZJ A901 · binds LEU595, GLY596, GLN597, VAL603, VAL640, LYS642, GLU688, TYR689 and 9 more

Residues it binds most

VAL 4, GLU 4, GLY 4, LEU 4, ARG 4, ASN 4, LYS 4, PRO 4, SER 4, TYR 4 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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