Ligand · IZA
IZA · 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinoline-7-one
IZA, 2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinoline-7-one (C18 H16 F N3 O, 309.3 g/mol), in the MolNFT structures on GenesisL1: bound in 16 records (8 PDB entries). Every binding site with its residues within 4.5 Å…
- Component
- IZA
- Formula
- C18 H16 F N3 O
- Class
- ligand
- Structures
- 16
- PDB entries
- 8
Binding sites
IZA in 16 structures; the first of them:
- 2B7A · The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus… · IZA A2001 · binds LEU855, GLY856, LYS857, GLY858, VAL863, ALA880, VAL911, MET929 and 11 more
- 2J90 · Crystal structure of human ZIP kinase in complex with a tetracyclic pyridone inhibitor… · IZA A300 · binds LEU19, GLY20, SER21, GLY22, VAL27, ALA40, LYS42, ILE77 and 8 more
- 3EYH · Crystal structures of JAK1 and JAK2 inhibitor complexes · IZA A2001 · binds LEU881, GLY882, GLU883, GLY884, VAL889, ALA906, LYS908, VAL938 and 12 more
- 3LJ2 · IRE1 complexed with JAK Inhibitor I · IZA A1 · binds LEU680, TYR682, GLY683, VAL689, ALA700, LYS702, ILE729, LEU745 and 12 more
- 3LXL · Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in… · IZA A1 · binds LEU828, GLY829, LYS830, VAL836, ALA853, VAL884, MET902, GLU903 and 9 more
- 3LXP · Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in… · IZA A1183 · binds ARG901, LEU903, GLY904, GLU905, GLY906, VAL911, ALA928, LYS930 and 11 more
- 3NZ0 · Non-phosphorylated TYK2 kinase with CMP6 · IZA A1 · binds ARG901, LEU903, GLY904, GLU905, GLY906, VAL911, ALA928, ILE960 and 10 more
- 4GL9 · Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and… · IZA A2001 · binds LEU855, LYS857, GLY858, VAL863, ALA880, VAL911, MET929, GLU930 and 9 more
- 2B7A · The structural basis of janus kinase 2 inhibition by a potent and specific pan-janus… · IZA A2001 · binds LEU855, GLY856, LYS857, GLY858, VAL863, ALA880, VAL911, MET929 and 11 more
- 2J90 · Crystal structure of human zip kinase in complex with a tetracyclic pyridone inhibitor… · IZA A300 · binds LEU19, GLY20, SER21, GLY22, VAL27, ALA40, LYS42, ILE77 and 8 more
- 3EYH · Crystal structures of JAK1 and JAK2 inhibitor complexes · IZA A2001 · binds LEU881, GLY882, GLU883, GLY884, VAL889, ALA906, LYS908, VAL938 and 12 more
- 3LJ2 · IRE1 complexed with JAK inhibitor I · IZA A1 · binds LEU680, TYR682, GLY683, VAL689, ALA700, LYS702, ILE729, LEU745 and 12 more
- 3LXL · Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in… · IZA A1 · binds LEU828, GLY829, LYS830, VAL836, ALA853, VAL884, MET902, GLU903 and 9 more
- 3LXP · Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in… · IZA A1183 · binds ARG901, LEU903, GLY904, GLU905, GLY906, VAL911, ALA928, LYS930 and 11 more
- 3NZ0 · Non-phosphorylated TYK2 kinase with CMP6 · IZA A1 · binds ARG901, LEU903, GLY904, GLU905, GLY906, VAL911, ALA928, ILE960 and 10 more
- 4GL9 · Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and… · IZA A2001 · binds LEU855, LYS857, GLY858, VAL863, ALA880, VAL911, MET929, GLU930 and 9 more
Residues it binds most
LEU 28, GLY 28, VAL 28, ASN 28, GLU 28, ASP 28, ALA 28, LYS 26, ARG 20, MET 24 (residue and the binding sites it lines).
Found with
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