UniProt P29474
Nitric oxide synthase, endothelial (P29474)
Nitric oxide synthase, endothelial (UniProt P29474), EC 1.14.13.39: 84 experimental structures on GenesisL1, 50 ligands bound, 361 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P29474
- Protein
- Nitric oxide synthase, endothelial
- EC
- 1.14.13.39
- Experimental structures
- 84
- Predicted models
- 0
- Ligands
- 50
- Pockets
- 361 · 19 records with a druggable one
Structures
84 records of P29474 in the MolNFT archive: 84 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1M9J | human endothelial nitric oxide synthase with chlorzoxazone bound | x-ray diffraction | A, B | — | — |
| 1M9J | Human endothelial nitric oxide synthase with chlorzoxazone bound | x-ray diffraction | A, B | — | — |
| 1M9K | Human Endothelial Nitric Oxide Synthase with 7-Nitroindazole Bound | x-ray diffraction | A, B | — | — |
| 1M9K | Human endothelial nitric oxide synthase with 7- nitroindazole bound | x-ray diffraction | A, B | — | — |
| 1M9M | human endothelial nitric oxide synthase with 6-nitroindazole bound | x-ray diffraction | A, B | — | — |
| 1M9M | Human endothelial nitric oxide synthase with 6- nitroindazole bound | x-ray diffraction | A, B | — | — |
| 1M9Q | human endothelial nitric oxide synthase with 5-nitroindazole bound | x-ray diffraction | A, B | — | — |
| 1M9Q | Human endothelial nitric oxide synthase with 5- nitroindazole bound | x-ray diffraction | A, B | — | — |
| 1M9R | human endothelial nitric oxide synthase with 3-Bromo-7-Nitroindazole bound | x-ray diffraction | A, B | — | — |
| 1M9R | Human endothelial nitric oxide synthase with 3-bromo-7- nitroindazole bound | x-ray diffraction | A, B | — | — |
| 1NIW | Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin | x-ray diffraction | B, D, F, H | — | — |
| 1NIW | Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin | x-ray diffraction | B, D, F, H | — | — |
| 2LL7 | Solution NMR structure of CaM bound to the eNOS CaM binding domain peptide | solution nmr | B | — | — |
| 2LL7 | Solution NMR structure of cam bound to the enos cam binding domain peptide | solution nmr | B | — | — |
| 2N8J | Structure and 15N relaxation data of Calmodulin bound to the endothelial Nitric Oxide Synthase… | solution nmr | B | — | — |
| 2N8J | Structure and 15N relaxation data of calmodulin bound to the endothelial nitric oxide synthase… | solution nmr | B | — | — |
| 3EAH | Structure of inhibited human eNOS oxygenase domain | x-ray diffraction | A, B | — | — |
| 3EAH | Structure of inhibited human enos oxygenase domain | x-ray diffraction | A, B | — | — |
| 3NOS | Human endothelial nitric oxide synthase with arginine substrate | x-ray diffraction | A, B | — | — |
| 3NOS | Human endothelial nitric oxide synthase with arginine substrate | x-ray diffraction | A, B | — | — |
| 4D1O | Structure of human endothelial nitric oxide synthase heme domain with L-Arg bound | x-ray diffraction | A, B | — | — |
| 4D1O | Structure of human endothelial nitric oxide synthase heme domain with L-arg bound | x-ray diffraction | A, B | — | — |
| 4D1P | Structure of human endothelial nitric oxide synthase heme domain IN COMPLEX WITH 6-((((3S… | x-ray diffraction | A, B | — | — |
| 4D1P | Structure of human endothelial nitric oxide synthase heme domain in complex with 6-((((3S… | x-ray diffraction | A, B | — | — |
| 5UO8 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 8EV, ZN, GD | 20 (best 0.85) |
| 5UO8 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 8EV, ZN, GD | — |
| 5UO9 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 8J4, ZN, CL, GD | — |
| 5UOA | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, 8EY, ZN, CL, GD | — |
| 5UOA | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B | HEM, 8EY, ZN, CL, GD | — |
| 5UOB | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, M4R, ZN, CL, GD | 20 (best 0.85) |
| 5UOB | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, M4R, ZN, CL, GD | — |
| 5UOC | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 8FD, ZN, CL, GD | — |
| 5VVB | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 9P7, ZN, CL, GD | — |
| 5VVC | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 9OJ, ZN, CL, GD | 20 (best 0.86) |
| 5VVC | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 9OJ, ZN, CL, GD | — |
| 5VVD | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 9OG, ZN, CL, GD | 18 (best 0.85) |
| 5VVD | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 9OG, ZN, CL, GD | — |
| 5XOF | Crystal structure of human paired immunoglobulin-like type 2 receptor alpha with synthesized… | x-ray diffraction | O, P, Q, R | NDG, SIA | — |
| 6AV6 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, W68, ZN, CL, H4B, GD | — |
| 6AV7 | Structure of human endothelial nitric oxide synthase heme domain in complex with HW69 | x-ray diffraction | A, B, C, D | HEM, H4B, W69, ZN, CL, GD | 20 (best 0.85) |
| 6AV7 | Structure of human endothelial nitric oxide synthase heme domain in complex with HW69 | x-ray diffraction | A, B, C, D | HEM, H4B, W69, ZN, CL, GD | — |
| 6CIE | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, 7R2, ZN, CL, GD | — |
| 6CIF | Structure of the human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, F2J, ZN, CL, GD | — |
| 6POU | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D, E, F | HEM, M16, ZN, GD | — |
| 6POU | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D, E, F | HEM, M16, ZN, GD | — |
| 6POV | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OUG, ZN, GD | 20 (best 0.86) |
| 6POV | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OUG, ZN, GD | — |
| 6POW | Structure of human endotheial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OUA, ZN, CL, GD | 20 (best 0.85) |
| 6POW | Structure of human endotheial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OUA, ZN, CL, GD | — |
| 6POX | Structure of human endothelialnitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OSJ, ZN, CL, GD | — |
| 6POY | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OSG, ZN, CL, GD | 20 (best 0.85) |
| 6POY | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OSG, ZN, CL, GD | — |
| 6POZ | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OSD, ZN, CL, GD | 20 (best 0.84) |
| 6POZ | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OSD, ZN, CL, GD | — |
| 6PP0 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OUP, ZN, CL, GD | — |
| 6PP0 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OUP, ZN, CL, GD | — |
| 6PP1 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OU1, CL, ZN, GD | — |
| 6PP2 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OUM, ZN, CL, GD | — |
| 6PP2 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OUM, ZN, CL, GD | — |
| 6PP3 | Structure of human endothelial nitric oxide synthase heme domain in complex with… | x-ray diffraction | A, B, C, D | HEM, H4B, OS7, ZN, CL, GD | — |
24 records more on the page itself.
Ligands
- GD · Gadolinium atom · in 58 records
- HEM · Protoporphyrin IX containing Fe · in 58 records
- ZN · Zinc ion · in 58 records
- CL · Chloride ion · in 51 records
- H4B · 5,6,7,8-tetrahydrobiopterin · in 51 records
- 8EV · 3-[(2-aminoquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile · in 2 records
- 8EY · 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(methylamino)methyl]benzonitrile · in 2 records
- 9OG · 4-(2-{[(2-amino-4-methylquinolin-7-yl) methyl]amino}ethyl)benzonitrile · in 2 records
- 9OJ · 4-(2-{[(2-amino-4-methylquinolin-7-yl) methyl]amino}ethyl)-2-methylbenzonitrile · in 2 records
- CA · Calcium ion · in 2 records
- K7U · 6-[3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl]-4-methylpyridin-2-amine · in 2 records
- K90 · 4-methyl-6-[3-(4-methylpiperazin-1-yl)prop-1-yn-1-yl]pyridin-2-amine · in 2 records
- KMI · 4-methyl-6-{3-[(methylamino)methyl]phenyl}pyridin-2-amine · in 2 records
- M16 · 7-[4-(2-aminoethyl)phenyl]-4-methylquinolin-2-amine · in 2 records
- M4R · 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2R)-2-(methylamino)propyl]benzonitrile · in 2 records
- M5L · 6-[3-(4,4-difluoropiperidin-1-yl)propyl]-4-methylpyridin-2-amine · in 2 records
- OSD · 7-{3-(aminomethyl)-4-[(propan-2-yl)oxy]phenyl}-4-methylquinolin-2-amine · in 2 records
- OSG · 7-[3-(aminomethyl)-4-propoxyphenyl]-4-methylquinolin-2-amine · in 2 records
- OUA · 7-[5-(aminomethyl)pyridin-3-yl]-4-methylquinolin-2-amine · in 2 records
- OUG · 7-[3-(aminomethyl)phenyl]-4-methylquinolin-2-amine · in 2 records
- OUM · 4-{[2-(aminomethyl)-4-(2-amino-4-methylquinolin-7-yl) phenoxy]methyl}benzonitrile · in 2 records
- OUP · 7-[3-(aminomethyl)-4-(cyclobutylmethoxy)phenyl]-4-methylquinolin-2-amine · in 2 records
- W69 · 6-(2-{3-[3-(dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine · in 2 records
- 7R2 · N-(1-{2-[ethyl(methyl)amino]ethyl}-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide · in 1 record
- 8FD · 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-[(2S)-2-(methylamino)propyl]benzonitrile · in 1 record
- 8J4 · 7-({3-ethyl-5-[(methylamino)methyl]phenoxy}methyl) quinolin-2-amine · in 1 record
- 9P7 · 4-(2-{[(2-aminoquinolin-7-yl)methyl]amino}ethyl)-2-methylbenzonitrile · in 1 record
- F2J · N-[1-(piperidin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide · in 1 record
- K8F · 6-[3-(3,3-difluoroazetidin-1-yl)propyl]-4-methylpyridin-2-amine · in 1 record
- K8O · 6-[3-(4,4-difluoropiperidin-1-yl)prop-1-yn-1-yl]-4-methylpyridin-2-amine · in 1 record
Elsewhere
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