GL1X · GenesisL1 explorer

Ligand · HAR

HAR · N-omega-hydroxy-L-arginine

HAR, N-omega-hydroxy-L-arginine (C6 H14 N4 O3, 190.2 g/mol), in the MolNFT structures on GenesisL1: bound in 25 records (17 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
HAR
Formula
C6 H14 N4 O3
Class
ligand
Structures
25
PDB entries
17

Binding sites

HAR in 25 structures; the first of them:

  • 1DWV · MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and 4-amino… · HAR A909 · binds GLN257, TRP340, TYR341, PRO344, VAL346, ASN364, GLY365, TRP366 and 4 more
  • 1DWW · MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and… · HAR A909 · binds GLN257, TRP340, TYR341, PRO344, VAL346, ASN364, GLY365, TRP366 and 3 more
  • 1DWX · MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and… · HAR A906 · binds GLN257, TRP340, TYR341, PRO344, VAL346, ASN364, GLY365, TRP366 and 3 more
  • 1HQF · Crystal structure of the binuclear manganese metalloenzyme arginase complexed with… · HAR A906 · binds HIS101, ASP124, HIS126, ASP128, ASN130, THR135, SER137, ASN139 and 8 more
  • 1LZX · Rat neuronal NOS heme domain with NG-hydroxy-L-arginine bound · HAR A770 · binds GLN478, TYR562, PRO565, VAL567, SER585, GLY586, TRP587, TYR588 and 2 more
  • 1M7Z · Structure of Nitric Oxide Synthase Heme Protein from Bacillus Subtilis with… · HAR A909 · binds GLN125, ARG128, TYR209, PRO212, ILE214, ASN232, GLY233, TRP234 and 4 more
  • 2FBZ · Heme-No complex in a bacterial Nitric Oxide Synthase · HAR X909 · binds GLN125, ARG128, TYR209, PRO212, ILE214, ASN232, GLY233, TRP234 and 4 more
  • 2FC2 · NO-HEME complex in a bacterial nitric oxide synthase. An Fe(III)-NO may cause nitrosation. · HAR A909 · binds GLN125, ARG128, TYR209, PRO212, ILE214, GLY233, TRP234, TYR235 and 3 more
  • 3HSN · Ternary structure of neuronal nitric oxide synthase with NHA and CO bound · HAR A770 · binds GLN478, TYR562, PRO565, VAL567, SER585, GLY586, TRP587, TYR588 and 4 more
  • 3HSO · Ternary structure of neuronal nitric oxide synthase with NHA and NO bound(1) · HAR A770 · binds GLN478, TYR562, PRO565, VAL567, SER585, GLY586, TRP587, TYR588 and 4 more
  • 3HSP · Ternary structure of neuronal nitric oxide synthase with NHA and NO bound(2) · HAR A770 · binds GLN478, TRP561, TYR562, PRO565, VAL567, SER585, GLY586, TRP587 and 5 more
  • 3LP7 · Crystal structure of Human Arginase I in complex with inhibitor… · HAR A906 · binds HIS101, ASP124, HIS126, ASP128, ASN130, THR135, SER137, HIS141 and 7 more
  • 3NOS · Human endothelial nitric oxide synthase with arginine substrate · HAR A512 · binds GLN247, ARG250, TRP330, TYR331, PRO334, VAL336, PHE353, SER354 and 5 more
  • 4Q3T · Crystal structure of Schistosoma mansoni arginase in complex with inhibitor NOHA · HAR A405 · binds HIS131, ASP154, HIS156, ASP158, ASN160, SER165, SER167, ASN169 and 8 more
  • 5NSE · Bovine endothelial nitric oxide synthase, H4B-free, hydroxy-arg complex · HAR A770 · binds GLN249, ARG252, TYR333, PRO336, VAL338, SER356, GLY357, TRP358 and 3 more
  • 5VKA · Ethylene forming enzyme in complex with manganese, 2-oxoglutarate and… · HAR A403 · binds GLU84, VAL85, THR86, ASP91, ARG171, ILE186, HIS189, ASP191 and 7 more
  • 5ZEE · Crystal structure of Entamoeba histolytica Arginase in complex with… · HAR A301 · binds HIS98, ASP124, HIS126, ASP128, ASN130, SER135, PRO136, SER137 and 8 more
  • 1DWV · Murine inducible nitric oxide synthase oxygenase dimer N-hydroxyarginine and 4-amino… · HAR A909 · binds GLN257, TRP340, TYR341, PRO344, VAL346, ASN364, GLY365, TRP366 and 4 more
  • 1DWW · Murine inducible nitric oxide synthase oxygenase dimer N-hydroxyarginine and… · HAR A909 · binds GLN257, TRP340, TYR341, PRO344, VAL346, ASN364, GLY365, TRP366 and 3 more
  • 1DWX · Murine inducible nitric oxide synthase oxygenase dimer N-hydroxyarginine and… · HAR A906 · binds GLN257, TRP340, TYR341, PRO344, VAL346, ASN364, GLY365, TRP366 and 3 more

Residues it binds most

ASP 37, TYR 35, GLU 49, ASN 38, GLY 48, TRP 34, HIS 15, PRO 36, GLN 34, SER 28 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • H4B · 5,6,7,8-tetrahydrobiopterin
  • MN · Manganese (II) ion
  • NO · Nitric oxide
  • SO4 · Sulfate ion
  • ACT · Acetate ion
  • H2B · 2-amino-6-(1,2-dihydroxy-propyl)-7,8-dihydro-6H-pteridin-4-one
  • GOL · Glycerol
  • 4AB · 2,4-diamino-6-[2,3-dihydroxy-prop-3-yl]-5,6,7,8-tetrahydropteridine
  • HBI · 7,8-dihydrobiopterin
  • THG · (6S)-5,6,7,8-tetrahydrofolate

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.