GL1X · GenesisL1 explorer

Ligand · H2B

H2B · 2-amino-6-(1,2-dihydroxy-propyl)-7,8-dihydro-6H-pteridin-4-one

H2B, 2-amino-6-(1,2-dihydroxy-propyl)-7,8-dihydro-6H-pteridin-4-one (C9 H13 N5 O3, 239.2 g/mol), in the MolNFT structures on GenesisL1: bound in 14 records (7 PDB entries). Every binding site with its residues within 4.5 Å, the residues it…

Component
H2B
Formula
C9 H13 N5 O3
Class
ligand
Structures
14
PDB entries
7

Binding sites

H2B in 14 structures; the first of them:

  • 1DWW · MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and… · H2B A902 · binds SER112, MET114, ARG375, ILE456, TRP457
  • 1TG2 · Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin… · H2B A426 · binds VAL245, GLY247, LEU248, LEU249, SER250, SER251, PHE254, LEU255 and 5 more
  • 2FBZ · Heme-No complex in a bacterial Nitric Oxide Synthase · H2B X903 · binds ARG243, THR324, TRP325
  • 2V6T · Crystal structure of a complex of pterin-4a-carbinolamine dehydratase from Toxoplasma… · H2B A1104 · binds ASP60, HIS61, HIS62, SER77, THR78, HIS79, ASP80, TYR69
  • 4CX1 · Structure of bovine endothelial nitric oxide synthase L111A mutant heme domain in complex… · H2B A600 · binds SER104, VAL106, ARG367, ALA448, TRP449, TRP76, TRP447, PHE462 and 3 more
  • 4CX2 · Structure of bovine endothelial nitric oxide synthase heme domain in complex with… · H2B A600 · binds SER104, VAL106, ARG367, ALA448, TRP449, TRP76, TRP447, PHE462 and 3 more
  • 4NOS · Human inducible nitric oxide synthase with inhibitor · H2B A511 · binds SER118, MET120, ARG381, ILE462, TRP463, TRP90, TRP461, PHE476 and 3 more
  • 1DWW · Murine inducible nitric oxide synthase oxygenase dimer N-hydroxyarginine and… · H2B A902 · binds SER112, MET114, ARG375, ILE456, TRP457
  • 1TG2 · Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8- dihydrobiopterin… · H2B A426 · binds VAL245, GLY247, LEU248, LEU249, SER250, SER251, PHE254, LEU255 and 5 more
  • 2FBZ · Heme-no complex in a bacterial nitric oxide synthase · H2B X903 · binds ARG243, THR324, TRP325
  • 2V6T · Crystal structure of a complex of pterin-4A-carbinolamine dehydratase from toxoplasma… · H2B A1104 · binds ASP60, HIS61, HIS62, SER77, THR78, HIS79, ASP80, TYR69
  • 4CX1 · Structure of bovine endothelial nitric oxide synthase L111A mutant heme domain in complex… · H2B A600 · binds SER104, VAL106, ARG367, ALA448, TRP449, TRP76, TRP447, PHE462 and 3 more
  • 4CX2 · Structure of bovine endothelial nitric oxide synthase heme domain in complex with… · H2B A600 · binds SER104, VAL106, ARG367, ALA448, TRP449, TRP76, TRP447, PHE462 and 3 more
  • 4NOS · Human inducible nitric oxide synthase with inhibitor · H2B A511 · binds SER118, MET120, ARG381, ILE462, TRP463, TRP90, TRP461, PHE476 and 3 more

Residues it binds most

TRP 16, HIS 16, SER 20, ARG 16, GLU 12, PHE 12, ALA 10, GLN 10, VAL 10, ASP 4 (residue and the binding sites it lines).

Found with

  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • HAR · N-omega-hydroxy-L-arginine
  • ACT · Acetate ion
  • H4B · 5,6,7,8-tetrahydrobiopterin
  • HW1 · 6-[5-({(3R,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}oxy)pentyl]-4-methylpyridin-2-amine
  • HW9 · 4-methyl-6-{[(3R,4R)-4-{[5-(4-methylpyridin-2-yl)pentyl]oxy}pyrrolidin-3-yl]methyl}pyridin-2-amine
  • ITU · Ethylisothiourea
  • FE · Fe (III) ion
  • NO · Nitric oxide
  • SO4 · Sulfate ion

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.