UniProt P29033
Gap junction beta-2 protein (P29033)
Gap junction beta-2 protein (UniProt P29033): 33 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 134 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P29033
- Protein
- Gap junction beta-2 protein
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 134 · 7 records with a druggable one
Structures
34 records of P29033 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ZW3 | Structure of the connexin-26 gap junction channel at 3.5 angstrom resolution | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2ZW3 | Structure of the connexin-26 gap junction channel at 3.5 ångström resolution | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3IZ1 | C-alpha model fitted into the EM structure of Cx26M34A | electron crystallography | A, B, C | — | — |
| 3IZ1 | C-alpha model fitted into the EM structure of CX26M34A | electron crystallography | A, B, C | — | — |
| 3IZ2 | C-alpha model fitted into the EM structure of Cx26M34Adel2-7 | electron crystallography | A, B, C | — | — |
| 3IZ2 | C-alpha model fitted into the EM structure of CX26M34ADEL2-7 | electron crystallography | A, B, C | — | — |
| 5ER7 | Connexin-26 Bound to Calcium | x-ray diffraction | B, A | CA | — |
| 5ER7 | Connexin-26 bound to calcium | x-ray diffraction | B, A | — | — |
| 5ERA | Human Connexin-26 (Calcium-free) | x-ray diffraction | B, A | — | — |
| 5ERA | Human connexin-26 (calcium-free) | x-ray diffraction | B, A | — | — |
| 5KJ3 | Connexin 26 WT peptide NMR Structure | solution nmr | A | — | — |
| 5KJ3 | Connexin 26 wt peptide NMR structure | solution nmr | A | ACE | — |
| 5KJG | Connexin 26 G12R mutant NMR structure | solution nmr | A | — | — |
| 5KJG | Connexin 26 G12R mutant NMR structure | solution nmr | A | ACE | — |
| 6UVR | Human connexin-26 (neutral pH open conformation) | electron microscopy | A, K, L, B, H, C, I, D, J, E, F, G | — | — |
| 6UVS | Human Connexin-26 (Low pH open conformation) | electron microscopy | A, K, L, B, H, C, I, D, J, E, F, G | — | 20 (best 0.84) |
| 6UVS | Human connexin-26 (low pH open conformation) | electron microscopy | A, K, L, B, H, C, I, D, J, E, F, G | — | — |
| 6UVT | Human Connexin-26 (Low pH closed conformation) | electron microscopy | A, K, L, B, H, C, I, D, J, E, F, G | — | 14 (best 0.62) |
| 6UVT | Human connexin-26 (low pH closed conformation) | electron microscopy | A, K, L, B, H, C, I, D, J, E, F, G | — | — |
| 7QEO | Human connexin 26 at 55MM hg PCO2, PH7.4: two masked subunits, class C | electron microscopy | A, B | PTY | — |
| 7QEQ | Human connexin 26 dodecamer at 90MMHG PCO2, PH7.4 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | PTY | — |
| 7QER | Human connexin 26 dodecamer at 55MM hg PCO2, PH7.4 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | PTY | — |
| 7QES | Human connexin 26 at 55MM hg PCO2, PH7.4: two masked subunits, class a | electron microscopy | A, B | PTY | — |
| 7QET | Human connexin 26 dodecamer at 20MMHG PCO2, PH7.4 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | PTY | — |
| 7QEU | human Connexin 26 at 55mmHg PCO2, pH7.4: two masked subunits, class B | electron microscopy | A, B | PTY | — |
| 7QEU | Human connexin 26 at 55MMHG PCO2, PH7.4: two masked subunits, class B | electron microscopy | A, B | PTY | — |
| 7QEV | Human connexin 26 at 55MM hg PCO2, PH7.4:TWO masked subunits, class D | electron microscopy | A, B | PTY | — |
| 7QEW | human Connexin 26 class 2 hexamer at 90mmHg PCO2, pH7.4 | electron microscopy | G, H, I, J, K, L | PTY | 20 (best 0.81) |
| 7QEW | Human connexin 26 class 2 hexamer at 90MMHG PCO2, PH7.4 | electron microscopy | G, H, I, J, K, L | PTY | — |
| 8QA0 | Cryo-EM structure of Cx26 solubilised in LMNG - hemichannel classification - NConst conformation | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | PTY | 20 (best 0.80) |
| 8QA1 | Cryo-EM structure of Cx26 solubilised in LMNG - Hemichannel classification NFlex conformation | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | PTY | 20 (best 0.77) |
| 8QA2 | Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; Nconst-mon conformation | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | PTY | 20 (best 0.82) |
| 8QA3 | Cryo-EM structure of Cx26 solubilised in LMNG: classification on subunit A; NFlex conformation | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | PTY | 20 (best 0.76) |
| P29033 | AlphaFold monomer V2.0 prediction for gap junction beta-2 protein (P29033) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8QA3 chain I against the predicted model P29033: TM-score 0.97, RMSD 0.91 Å
- 8QA3 chain G against the predicted model P29033: TM-score 0.97, RMSD 0.94 Å
- 8QA3 chain H against the predicted model P29033: TM-score 0.97, RMSD 0.98 Å
- 8QA0 chain I against the predicted model P29033: TM-score 0.97, RMSD 0.97 Å
- 8QA2 chain K against the predicted model P29033: TM-score 0.97, RMSD 0.96 Å
- 8QA0 chain G against the predicted model P29033: TM-score 0.97, RMSD 0.97 Å
- 8QA0 chain J against the predicted model P29033: TM-score 0.97, RMSD 0.97 Å
- 8QA2 chain F against the predicted model P29033: TM-score 0.97, RMSD 1.01 Å
- 8QA0 chain H against the predicted model P29033: TM-score 0.97, RMSD 0.98 Å
- 8QA2 chain H against the predicted model P29033: TM-score 0.97, RMSD 0.99 Å
Elsewhere
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