MolNFT v1 · #185790 · protein
Human connexin 26 at 55MM hg PCO2, PH7.4: two masked subunits, class a
7QES · Gap junction beta-2 protein: “Human connexin 26 at 55MM hg PCO2, PH7.4: two masked subunits, class a”. Electron microscopy, 1 ligand (PTY), 4 pockets (best druggability 0.82). MolNFT v1 #185790 on GenesisL1: 3D structure, binding…
- PDB
- 7QES
- Type
- protein
- Length
- 366 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gap junction beta-2 protein
- UniProt
- P29033
- Ligands
- PTY
- Pockets
- 4 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 69% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gap junction beta-2 protein | protein | 184 | 68% helix, 5% strand | P29033 |
| B | Gap junction beta-2 protein | protein | 182 | 70% helix, 5% strand | P29033 |
Ligands and binding sites
- PTY · Phosphatidylethanolamine · ligand · 2 copies · chains A, B
- LMT · Dodecyl-beta-D-maltoside · additive · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1021 | 0.82 | 0.83 | 103 | empty |
| 2 | 78 | 0.49 | 0.83 | 18 | empty |
| 3 | 83 | 0.45 | 0.80 | 18 | empty |
| 4 | 127 | 0.41 | 0.74 | 17 | LMT |
Interfaces
1 interface between chains.
- A–B · 1346 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7QES · human Connexin 26 at 55mm Hg PCO2, pH7.4: two masked subunits, class A · the same entry in another collection · chain A against A, TM-score 1.00
- P29033 · AlphaFold monomer V2.0 prediction for gap junction beta-2 protein (P29033) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29033
- Elsewhere: RCSB PDB 7QES · PDBe 7QES · UniProt P29033
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