MolNFT v1 · #166616 · protein
Human connexin-26 (neutral pH open conformation)
6UVR · Gap junction beta-2 protein: “Human connexin-26 (neutral pH open conformation)”. Electron microscopy, 20 pockets (best druggability 0.76). MolNFT v1 #166616 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6UVR
- Type
- protein
- Length
- 1,920 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gap junction beta-2 protein
- UniProt
- P29033
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 64% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, K, L, B, H, C, I, D, J, E, F, G | Gap junction beta-2 protein | protein | 160 | 64% helix, 6% strand | P29033 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 436 | 0.76 | 0.85 | 58 | empty |
| 2 | 544 | 0.76 | 0.83 | 63 | empty |
| 3 | 424 | 0.76 | 0.85 | 56 | empty |
| 4 | 448 | 0.76 | 0.84 | 58 | empty |
| 5 | 367 | 0.75 | 0.85 | 49 | empty |
Interfaces
24 interfaces between chains.
- H–D · 937 Ų buried · 5 hydrogen bonds · protein-protein
- J–F · 930 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 921 Ų buried · 5 hydrogen bonds · protein-protein
- J–E · 918 Ų buried · 6 hydrogen bonds · protein-protein
- A–I · 917 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 disulfide (disulfide).
Compared structures
- 6UVR · Human Connexin-26 (Neutral pH open conformation) · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29033
- Elsewhere: RCSB PDB 6UVR · PDBe 6UVR · UniProt P29033
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