MolNFT v1 · #118081 · protein

Human connexin-26 (calcium-free)

5ERA · Gap junction beta-2 protein: “Human connexin-26 (calcium-free)”. X-ray diffraction, 3 pockets (best druggability 0.44). MolNFT v1 #118081 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5ERA
Type: protein
Length: 315 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gap junction beta-2 protein
UniProt: P29033
Pockets: 3 · best druggability 0.44

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Gap junction beta-2 protein	protein	155	66% helix, 8% strand	P29033
A	Gap junction beta-2 protein	protein	160	66% helix, 8% strand	P29033

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	120	0.44	0.76	19	empty
2	149	0.43	0.75	23	empty
3	87	0.41	0.78	15	empty

Interfaces

1 interface between chains.

B–A · 1184 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

5ERA · Human Connexin-26 (Calcium-free) · the same entry in another collection · chain B against B, TM-score 1.00
P29033 · AlphaFold monomer V2.0 prediction for gap junction beta-2 protein (P29033) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P29033
Elsewhere: RCSB PDB 5ERA · PDBe 5ERA · UniProt P29033

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