UniProt P29016
T-cell surface glycoprotein CD1b (P29016)
T-cell surface glycoprotein CD1b (UniProt P29016): 32 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P29016
- Protein
- T-cell surface glycoprotein CD1b
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 27 · 4 records with a druggable one
Structures
33 records of P29016 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GZP | CD1b in complex with GM2 ganglioside | x-ray diffraction | A | — | — |
| 1GZP | CD1B in complex with GM2 ganglioside | x-ray diffraction | A | — | — |
| 1GZQ | CD1b in complex with Phophatidylinositol | x-ray diffraction | A | — | — |
| 1GZQ | CD1B in complex with phophatidylinositol | x-ray diffraction | A | — | — |
| 1UQS | The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid | x-ray diffraction | A | — | — |
| 1UQS | The crystal structure of human CD1B with a bound bacterial glycolipid | x-ray diffraction | A | — | — |
| 2H26 | human CD1b in complex with endogenous phosphatidylcholine and spacer | x-ray diffraction | A | — | — |
| 2H26 | Human CD1B in complex with endogenous phosphatidylcholine and spacer | x-ray diffraction | A | — | — |
| 3OV6 | CD1c in complex with MPM (mannosyl-beta1-phosphomycoketide) | x-ray diffraction | A | — | — |
| 3OV6 | CD1C in complex with mpm (mannosyl-BETA1-phosphomycoketide) | x-ray diffraction | A | — | — |
| 3T8X | Crystal structure of human CD1b in complex with synthetic antigenic diacylsulfoglycolipid SGL12 and… | x-ray diffraction | A, C | — | — |
| 3T8X | Crystal structure of human CD1B in complex with synthetic antigenic diacylsulfoglycolipid SGL12 and… | x-ray diffraction | A, C | — | — |
| 4ONO | CD1c in complex with PM (phosphomycoketide) | x-ray diffraction | A | — | — |
| 4ONO | CD1C in complex with pm (phosphomycoketide) | x-ray diffraction | A | — | — |
| 5C9J | Human CD1C with ligands in a' and F' channel | x-ray diffraction | A | — | — |
| 5L2J | Crystal structure of human CD1B in complex with C36-gmm | x-ray diffraction | A | NAG, FUC, 6UL, CL, 70E | — |
| 5L2K | Crystal structure of GEM42 TCR-CD1b-GMM complex | x-ray diffraction | A | NAG, SO4, CL, NA, 6UL, 70E | 6 (best 0.90) |
| 5L2K | Crystal structure of GEM42 TCR-CD1B-gmm complex | x-ray diffraction | A | NAG, SO4, CL, NA, 6UL, 70E | — |
| 5WKE | Crystal Structure of Human CD1b in Complex with PS | x-ray diffraction | A | NAG, FUC, CUY, CL, P50, NA | 6 (best 0.87) |
| 5WKE | Crystal structure of human CD1B in complex with ps | x-ray diffraction | A | NAG, FUC, CUY, CL, NA | — |
| 5WKG | Crystal Structure of Human CD1b in Complex with PA | x-ray diffraction | A | NAG, FUC, D21, CUY, CL, IOD | — |
| 5WKG | Crystal structure of human CD1B in complex with pa | x-ray diffraction | A | NAG, FUC, D21, CUY, CL, IOD | — |
| 5WKI | Crystal structure of PG90 TCR-CD1B-pg complex | x-ray diffraction | A | NAG, FUC, CUY, D3D | — |
| 5WL1 | Crystal Structure of Human CD1b in Complex with PG | x-ray diffraction | A | NAG, FUC, CUY, IOD, CL, NA | — |
| 5WL1 | Crystal structure of human CD1B in complex with pg | x-ray diffraction | A | NAG, FUC, CUY, IOD, CL, NA | — |
| 6CUG | Crystal structure of BC8B TCR-CD1B-pc complex | x-ray diffraction | A | NAG, CUY, POV | — |
| 6D64 | Crystal structure of human CD1B in complex with popc | x-ray diffraction | A | NAG, FUC, POV, CUY, CL, NA | — |
| 7MX4 | CD1c with antigen analogue 1 | x-ray diffraction | A | NAG, ZPD, D12, ZP7 | 6 (best 0.84) |
| 7MX4 | CD1C with antigen analogue 1 | x-ray diffraction | A | NAG, ZPD, D12, ZP7 | — |
| 7MXF | CD1C with antigen analogue 2 | x-ray diffraction | A | NAG, ZQ4, D12, ZP7 | — |
| 7MXH | CD1c with antigen analogue 3 | x-ray diffraction | A | NAG, ZQ7, D12, ZP7 | 9 (best 0.85) |
| 7MXH | CD1C with antigen analogue 3 | x-ray diffraction | A | NAG, ZQ7, D12, ZP7 | — |
| P29016 | AlphaFold monomer V2.0 prediction for T-cell surface glycoprotein CD1B (P29016) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 17 records
- CL · Chloride ion · in 10 records
- CUY · tetracosyl octadecanoate · in 9 records
- FUC · alpha-L-fucopyranose · in 9 records
- NA · Sodium ion · in 7 records
- D12 · Dodecane · in 5 records
- IOD · Iodide ion · in 5 records
- ZP7 · (2S)-2,3-dihydroxypropyl hexadecanoate · in 5 records
- 6UL · Tetracosyl palmitate · in 3 records
- 70E · 6-O-[(2R,3R)-3-hydroxy-2-tetradecyldocosanoyl]-alpha-L-idopyranose · in 3 records
- D3D · (19S,22R,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9E)-octadec-9-enoate · in 3 records
- D21 · (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate · in 2 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 2 records
- SO4 · Sulfate ion · in 2 records
- ZPD · (4S,8R,12S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl (1R,2S,3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl) cyclohexyl hydrogen (R)-phosphate · in 2 records
- ZQ7 · 2,6-anhydro-1-deoxy-1,1-difluoro-1-[(R)-hydroxy{[(4s, 8S,12S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-D-glycero-D-galacto-heptitol · in 2 records
- P50 · (19S,22S,25R)-25-amino-22-hydroxy-16,22,26-trioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate · in 1 record
- ZQ4 · 2,6-anhydro-1-deoxy-1-[(S)-hydroxy{[(4r,8s,12r,16r, 20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-D-glycero-D-galacto-heptitol · in 1 record
Experiment against prediction
- 3T8X chain A against the predicted model P29016: TM-score 0.99, RMSD 0.66 Å
- 3T8X chain A against the predicted model P29016: TM-score 0.99, RMSD 0.66 Å
- 1GZQ chain A against the predicted model P29016: TM-score 0.99, RMSD 0.71 Å
- 1GZQ chain A against the predicted model P29016: TM-score 0.99, RMSD 0.71 Å
- 1GZP chain A against the predicted model P29016: TM-score 0.99, RMSD 0.72 Å
- 1GZP chain A against the predicted model P29016: TM-score 0.99, RMSD 0.72 Å
- 5L2K chain A against the predicted model P29016: TM-score 0.98, RMSD 0.83 Å
- 5L2K chain A against the predicted model P29016: TM-score 0.98, RMSD 0.83 Å
- 3T8X chain C against the predicted model P29016: TM-score 0.98, RMSD 0.84 Å
- 3T8X chain C against the predicted model P29016: TM-score 0.98, RMSD 0.84 Å
Elsewhere
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