UniProt P21951
DNA polymerase epsilon catalytic subunit A (P21951)
DNA polymerase epsilon catalytic subunit A (UniProt P21951), EC 2.7.7.7, 3.1.11.-: 39 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 212 pockets. Binding sites, druggability and experiment against…
- UniProt
- P21951
- Protein
- DNA polymerase epsilon catalytic subunit A
- EC
- 2.7.7.7, 3.1.11.-
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 212 · 20 records with a druggable one
Structures
40 records of P21951 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4M8O | TERNARY COMPLEX OF DNA POLYMERASE EPSILON WITH AN INCOMING dATP | x-ray diffraction | A | — | — |
| 4M8O | Ternary complex of DNA polymerase epsilon with an incoming datp | x-ray diffraction | A | — | — |
| 4PTF | Ternary crystal structure of yeast DNA polymerase epsilon with template G | x-ray diffraction | A | — | — |
| 4PTF | Ternary crystal structure of yeast DNA polymerase epsilon with template G | x-ray diffraction | A | — | — |
| 5OKI | Crystal structure of the Ctf18-1-8 module from Ctf18-RFC in complex with a 63 kDa fragment of DNA… | x-ray diffraction | A, B | — | 11 (best 0.70) |
| 5OKI | Crystal structure of the CTF18-1-8 module from CTF18-rfc in complex with a 63 kda fragment of DNA… | x-ray diffraction | A, B | — | — |
| 6FWK | The crystal structure of Pol2CORE-M644G in complex with DNA and an incoming nucleotide | x-ray diffraction | A, B | DTP, CA, FE | 20 (best 0.79) |
| 6FWK | The crystal structure of POL2CORE-M644G in complex with DNA and an incoming nucleotide | x-ray diffraction | A, B | DTP, CA, FE | — |
| 6G0A | The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R… | x-ray diffraction | A | DTP, CA, FE | 12 (best 0.76) |
| 6G0A | The crystal structure of the POL2 catalytic domain of DNA polymerase epsilon carrying a P301R… | x-ray diffraction | A | DTP, CA, FE | — |
| 6H1V | The crystal structure of POL2CORE in complex with DNA and an incoming nucleotide, carrying an fe-S… | x-ray diffraction | A | SF4, DTP, MG | — |
| 6HV8 | Cryo-EM structure of S. cerevisiae polymerase epsilon deltacat mutant | electron microscopy | A | ZN | — |
| 6HV9 | S. cerevisiae cmg-pol epsilon-DNA | electron microscopy | A | ZN | — |
| 6I8A | The crystal structure of the Pol2 catalytic domain of DNA polymerase epsilon carrying a P301R… | x-ray diffraction | A, B | DTP, CA, FE | — |
| 6I8A | The crystal structure of the POL2 catalytic domain of DNA polymerase epsilon carrying a P301R… | x-ray diffraction | A, B | DTP, CA, FE | — |
| 6QIB | The crystal structure of Pol2CORE in complex with DNA and an incoming nucleotide, carrying an Fe-S… | x-ray diffraction | A | SF4, DTP, CA | 16 (best 0.77) |
| 6QIB | The crystal structure of POL2CORE in complex with DNA and an incoming nucleotide, carrying an fe-S… | x-ray diffraction | A | SF4, DTP, CA | — |
| 6S1C | P3221 crystal form of the CTF18-1-8/POL2(1-528) complex | x-ray diffraction | A, E | — | — |
| 6S2E | Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon | electron microscopy | A | SF4 | 15 (best 0.77) |
| 6S2E | Cryo-EM structure of CTF18-1-8 in complex with the catalytic domain of DNA polymerase epsilon | electron microscopy | A | SF4 | — |
| 6S2F | Cryo-EM structure of Ctf18-1-8 in complex with the catalytic domain of DNA polymerase epsilon… | electron microscopy | A | SF4 | 12 (best 0.83) |
| 6S2F | Cryo-EM structure of CTF18-1-8 in complex with the catalytic domain of DNA polymerase epsilon… | electron microscopy | A | SF4 | — |
| 6WJV | Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme | electron microscopy | A | ZN | 17 (best 0.88) |
| 6WJV | Structure of the saccharomyces cerevisiae polymerase epsilon holoenzyme | electron microscopy | A | ZN | — |
| 7PMN | S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II) | electron microscopy | Q | ZN | 2 (best 0.78) |
| 7QHS | S. cerevisiae CMGE nucleating origin DNA melting | electron microscopy | G | ZN | 3 (best 0.86) |
| 7R3X | The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming… | x-ray diffraction | A | DTP, CA | — |
| 7R3X | The crystal structure of the L439V variant of POL2CORE in complex with DNA and an incoming… | x-ray diffraction | A | DTP, CA | 13 (best 0.78) |
| 7Z13 | S. cerevisiae CMGE dimer nucleating origin DNA melting | electron microscopy | N, Q | ZN | 2 (best 0.86) |
| 8B67 | The crystal structure of M644G variant of DNA Pol Epsilon containing CTP in the polymerase active… | x-ray diffraction | A | CA, CTP | 12 (best 0.78) |
| 8B6K | The crystal structure of M644G variant of DNA Pol Epsilon containing dCTP in the polymerase active… | x-ray diffraction | A, B | CA, DCP | 20 (best 0.78) |
| 8B77 | The crystal structure of N828V variant of DNA Pol Epsilon containing dATP in the polymerase active… | x-ray diffraction | A | DTP, CA | — |
| 8B7E | The crystal structure of N828V variant of DNA Pol Epsilon containing UTP in the polymerase active… | x-ray diffraction | A, B | UTP, CA | 20 (best 0.76) |
| 8KG6 | Yeast replisome in state I | electron microscopy | M | ZN | 3 (best 0.84) |
| 8KG9 | Yeast replisome in state III | electron microscopy | M | ZN | 3 (best 0.87) |
| 8P62 | S. cerevisiae ssDNA-sCMGE after DNA replication initiation | electron microscopy | G | ZN | 3 (best 0.88) |
| 8P63 | S. cerevisiae consensus-sCMGE on ssDNA after DNA replication initiation | electron microscopy | G | ZN | 2 (best 0.89) |
| 8TW9 | Cryo-EM structure of S. cerevisiae PolE-Ctf18-8-1-DNA | electron microscopy | E | SF4 | 17 (best 0.79) |
| 8TWA | Cryo-EM structure of S. cerevisiae Ctf18-RFC-PCNA-PolE-DNA complex | electron microscopy | E | SF4 | 9 (best 0.79) |
| P21951 | AlphaFold monomer V2.0 prediction for DNA polymerase epsilon catalytic subunit a (P21951) | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 14 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 12 records
- ZN · Zinc ion · in 11 records
- SF4 · Iron/sulfur cluster · in 9 records
- FE · Fe (III) ion · in 6 records
- CTP · Cytidine-5'-triphosphate · in 1 record
- DCP · 2'-deoxycytidine-5'-triphosphate · in 1 record
- MG · Magnesium ion · in 1 record
- UTP · Uridine 5'-triphosphate · in 1 record
Experiment against prediction
- 6S1C chain E against the predicted model P21951: TM-score 0.99, RMSD 0.64 Å
- 8B67 chain A against the predicted model P21951: TM-score 0.99, RMSD 1.05 Å
- 6G0A chain A against the predicted model P21951: TM-score 0.99, RMSD 1.26 Å
- 6G0A chain A against the predicted model P21951: TM-score 0.99, RMSD 1.26 Å
- 4PTF chain A against the predicted model P21951: TM-score 0.99, RMSD 1.61 Å
- 4PTF chain A against the predicted model P21951: TM-score 0.99, RMSD 1.61 Å
- 6FWK chain A against the predicted model P21951: TM-score 0.99, RMSD 1.57 Å
- 6FWK chain A against the predicted model P21951: TM-score 0.99, RMSD 1.57 Å
- 4M8O chain A against the predicted model P21951: TM-score 0.99, RMSD 1.67 Å
- 4M8O chain A against the predicted model P21951: TM-score 0.99, RMSD 1.67 Å
Elsewhere
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