UniProt P21836
Acetylcholinesterase (P21836)
Acetylcholinesterase (UniProt P21836), EC 3.1.1.7: 179 experimental structures and 1 predicted model on GenesisL1, 28 ligands bound, 79 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P21836
- Protein
- Acetylcholinesterase
- EC
- 3.1.1.7
- Experimental structures
- 179
- Predicted models
- 1
- Ligands
- 28
- Pockets
- 79 · 6 records with a druggable one
Structures
180 records of P21836 in the MolNFT archive: 179 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C2B | Electrophorus electricus acetylcholinesterase | x-ray diffraction | A | — | — |
| 1C2B | Electrophorus electricus acetylcholinesterase | x-ray diffraction | A | — | — |
| 1C2O | Electrophorus electricus acetylcholinesterase | x-ray diffraction | A, B, C, D | — | — |
| 1C2O | Electrophorus electricus acetylcholinesterase | x-ray diffraction | A, B, C, D | — | — |
| 1J06 | Crystal structure of mouse acetylcholinesterase in the apo form | x-ray diffraction | A, B | — | — |
| 1J06 | Crystal structure of mouse acetylcholinesterase in the apo form | x-ray diffraction | A, B | — | — |
| 1J07 | Crystal structure of the mouse acetylcholinesterase-decidium complex | x-ray diffraction | A, B | — | — |
| 1J07 | Crystal structure of the mouse acetylcholinesterase-decidium complex | x-ray diffraction | A, B | — | — |
| 1KU6 | Fasciculin 2-Mouse Acetylcholinesterase Complex | x-ray diffraction | A | — | — |
| 1KU6 | Fasciculin 2-mouse acetylcholinesterase complex | x-ray diffraction | A | — | — |
| 1MAA | Mouse acetylcholinesterase catalytic domain, glycosylated protein | x-ray diffraction | A, B, C, D | — | — |
| 1MAA | Mouse acetylcholinesterase catalytic domain, glycosylated protein | x-ray diffraction | A, B, C, D | — | — |
| 1MAH | FASCICULIN2-mouse acetylcholinesterase complex | x-ray diffraction | A | — | — |
| 1MAH | FASCICULIN2-mouse acetylcholinesterase complex | x-ray diffraction | A | — | — |
| 1N5M | Crystal structure of the mouse acetylcholinesterase-gallamine complex | x-ray diffraction | A, B | — | — |
| 1N5M | Crystal structure of the mouse acetylcholinesterase-gallamine complex | x-ray diffraction | A, B | — | — |
| 1N5R | Crystal structure of the mouse acetylcholinesterase-propidium complex | x-ray diffraction | A, B | — | — |
| 1N5R | Crystal structure of the mouse acetylcholinesterase-propidium complex | x-ray diffraction | A, B | — | — |
| 1Q83 | Crystal structure of the mouse acetylcholinesterase-TZ2PA6 syn complex | x-ray diffraction | A, B | — | — |
| 1Q83 | Crystal structure of the mouse acetylcholinesterase-TZ2PA6 syn complex | x-ray diffraction | A, B | — | — |
| 1Q84 | Crystal structure of the mouse acetylcholinesterase-TZ2PA6 anti complex | x-ray diffraction | A, B | — | — |
| 1Q84 | Crystal structure of the mouse acetylcholinesterase-TZ2PA6 anti complex | x-ray diffraction | A, B | — | — |
| 2C0P | Aged form of mouse acetylcholinesterase inhibited by tabun | x-ray diffraction | A, B | — | — |
| 2C0P | Aged form of mouse acetylcholinesterase inhibited by tabun | x-ray diffraction | A, B | — | — |
| 2C0Q | non-aged form of mouse acetylcholinesterase inhibited by tabun | x-ray diffraction | A, B | — | — |
| 2C0Q | Non-aged form of mouse acetylcholinesterase inhibited by tabun | x-ray diffraction | A, B | — | — |
| 2GYU | Crystal structure of Mus musculus Acetylcholinesterase in complex with HI-6 | x-ray diffraction | A, B | — | — |
| 2GYU | Crystal structure of mus musculus acetylcholinesterase in complex with hi-6 | x-ray diffraction | A, B | — | — |
| 2GYV | Crystal structure of Mus musculus Acetylcholinesterase in complex with Ortho-7 | x-ray diffraction | A, B | — | — |
| 2GYV | Crystal structure of mus musculus acetylcholinesterase in complex with ortho-7 | x-ray diffraction | A, B | — | — |
| 2GYW | Crystal Structure of Mus musculus Acetylcholinesterase in Complex with Obidoxime | x-ray diffraction | A, B | — | — |
| 2GYW | Crystal structure of mus musculus acetylcholinesterase in complex with obidoxime | x-ray diffraction | A, B | — | — |
| 2H9Y | Crystal structure of mouse acetylcholinesterase complexed with… | x-ray diffraction | A, B | — | — |
| 2H9Y | Crystal structure of mouse acetylcholinesterase complexed with M-(N,N… | x-ray diffraction | A, B | — | — |
| 2HA0 | Crystal structure of mouse acetylcholinesterase complexed with 4-ketoamyltrimethylammonium | x-ray diffraction | A, B | — | — |
| 2HA0 | Crystal structure of mouse acetylcholinesterase complexed with 4- ketoamyltrimethylammonium | x-ray diffraction | A, B | — | — |
| 2HA2 | Crystal structure of mouse acetylcholinesterase complexed with succinylcholine | x-ray diffraction | A, B | — | — |
| 2HA2 | Crystal structure of mouse acetylcholinesterase complexed with succinylcholine | x-ray diffraction | A, B | — | — |
| 2HA3 | Crystal structure of mouse acetylcholinesterase complexed with choline | x-ray diffraction | A, B | — | — |
| 2HA3 | Crystal structure of mouse acetylcholinesterase complexed with choline | x-ray diffraction | A, B | — | — |
| 2HA4 | Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with acetylcholine | x-ray diffraction | A, B | — | — |
| 2HA4 | Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with acetylcholine | x-ray diffraction | A, B | — | — |
| 2HA5 | Crystal structure of mutant S203A of acetylcholinesterase complexed with acetylthiocholine | x-ray diffraction | A, B | — | — |
| 2HA5 | Crystal structure of mutant S203A of acetylcholinesterase complexed with acetylthiocholine | x-ray diffraction | A, B | — | — |
| 2HA6 | Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with succinylcholine | x-ray diffraction | A, B | — | — |
| 2HA6 | Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with succinylcholine | x-ray diffraction | A, B | — | — |
| 2HA7 | Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with butyrylthiocholine | x-ray diffraction | A, B | — | — |
| 2HA7 | Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with butyrylthiocholine | x-ray diffraction | A, B | — | — |
| 2JEY | Mus musculus acetylcholinesterase in complex with HLo-7 | x-ray diffraction | A, B | — | — |
| 2JEY | Mus musculus acetylcholinesterase in complex with hlo-7 | x-ray diffraction | A, B | — | — |
| 2JEZ | Mus musculus acetylcholinesterase in complex with tabun and HLo-7 | x-ray diffraction | A, B | — | — |
| 2JEZ | Mus musculus acetylcholinesterase in complex with tabun and hlo-7 | x-ray diffraction | A, B | — | — |
| 2JF0 | Mus musculus acetylcholinesterase in complex with tabun and Ortho-7 | x-ray diffraction | A, B | — | — |
| 2JF0 | Mus musculus acetylcholinesterase in complex with tabun and ortho-7 | x-ray diffraction | A, B | — | — |
| 2JGE | Crystal structure of mouse acetylcholinesterase inhibited by non-aged methamidophos | x-ray diffraction | A, B | — | — |
| 2JGE | Crystal structure of mouse acetylcholinesterase inhibited by non-aged methamidophos | x-ray diffraction | A, B | — | — |
| 2JGF | Crystal structure of mouse acetylcholinesterase inhibited by non-aged fenamiphos | x-ray diffraction | A, B | — | — |
| 2JGF | Crystal structure of mouse acetylcholinesterase inhibited by non-aged fenamiphos | x-ray diffraction | A, B | — | — |
| 2JGI | Crystal structure of mouse acetylcholinesterase inhibited by non-aged diisopropyl fluorophosphate… | x-ray diffraction | A, B | — | — |
| 2JGI | Crystal structure of mouse acetylcholinesterase inhibited by non-aged diisopropyl fluorophosphate… | x-ray diffraction | A, B | — | — |
120 records more on the page itself.
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 19 records
- TOE · 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxyl · in 9 records
- I1X · 4-methyl-3-nitro-~{N}-[(2~{E},4~{E})-5-[2-[(oxidanylamino)methyl]pyridin-1-yl]penta-2,4-dienyl]benzamide · in 6 records
- P15 · 2,5,8,11,14,17-hexaoxanonadecan-19-ol · in 6 records
- 1PG · 2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol · in 3 records
- 7PG · 2,5,8,11,14,17,20,23-octaoxapentacosan-25-ol · in 3 records
- 9YU · 2-[2-[2-[2-[2-[2-(2-methoxyethoxy) ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol · in 3 records
- CL · Chloride ion · in 3 records
- 5NZ · 6-phenyl-5-[5-[3-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-1,2,3-triazol-4-yl]pentyl]phenanthridin-5-ium-3,8-diamine · in 2 records
- AE3 · 2-(2-ethoxyethoxy)ethanol · in 2 records
- E5H · 2-(4-phenylphenoxy)-~{N}-(3-piperidin-1-ylpropyl) ethanamide · in 2 records
- ETE · 2-{2-[2-2-(methoxy-ethoxy)-ethoxy]-ethoxy}-ethanol · in 2 records
- I62 · ~{N}-[(~{E})-3-(diethylamino)prop-2-enyl]-4-methyl-3-nitro-benzamide · in 2 records
- N2K · ~{N}-[2-(diethylamino)ethyl]-1-[4-(trifluoromethyl) phenyl]methanesulfonamide · in 2 records
- 5G8 · 1-[5-(2,4-dichlorophenoxy)pentyl]-1H-imidazole · in 1 record
- 5IK · 4-(hydroxymethyl)-7-[[4-[[methyl-(phenylmethyl) amino]methyl]phenyl]methoxy]chromen-2-one · in 1 record
- AJ9 · 3,4-dimethyl-7-[[1-(phenylmethyl)piperidin-4-yl]methoxy]chromen-2-one · in 1 record
- CO3 · Carbonate ion · in 1 record
- CVI · Crystal violet · in 1 record
- E5K · 1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]-2-[4-(4-methoxyphenyl)phenoxy]ethanone · in 1 record
- ETX · 2-ethoxyethanol · in 1 record
- FUC · alpha-L-fucopyranose · in 1 record
- G0W · 1,3-bis[5(diethyl-O-nitrobenzylammonium)pentyl]-6-methyluracil · in 1 record
- HI6 · 4-(aminocarbonyl)-1-[({2-[(E)-(hydroxyimino)methyl]pyridinium-1-yl}methoxy)methyl]pyridinium · in 1 record
- I4H · ~{N}-ethyl-4-methyl-3-nitro-benzamide · in 1 record
- SO4 · Sulfate ion · in 1 record
- SOF · 2-(biphenyl-4-yloxy)-1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]ethanone · in 1 record
- TZ2 · ~{N}-(2-azidoethyl)-1,2,3,4-tetrahydroacridin-9-amine · in 1 record
Experiment against prediction
- 1N5M chain B against the predicted model P21836: TM-score 1.00, RMSD 0.37 Å
- 1N5M chain B against the predicted model P21836: TM-score 1.00, RMSD 0.37 Å
- 1N5R chain B against the predicted model P21836: TM-score 1.00, RMSD 0.39 Å
- 1N5R chain B against the predicted model P21836: TM-score 1.00, RMSD 0.39 Å
- 1J06 chain B against the predicted model P21836: TM-score 1.00, RMSD 0.39 Å
- 1J06 chain B against the predicted model P21836: TM-score 1.00, RMSD 0.39 Å
- 2WHP chain B against the predicted model P21836: TM-score 1.00, RMSD 0.39 Å
- 2WHP chain B against the predicted model P21836: TM-score 1.00, RMSD 0.39 Å
- 2Y2V chain B against the predicted model P21836: TM-score 1.00, RMSD 0.40 Å
- 2Y2V chain B against the predicted model P21836: TM-score 1.00, RMSD 0.40 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.