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Ligand · TZ4

TZ4 · 3,8-diamino-6-phenyl-5-[6-[1-[2-[(1,2,3,4-tetrahydro-9-acridinyl)amino]ethyl]-1H-1,2,3-triazol-4-yl]hexyl]-phenanthridinium

TZ4, 3,8-diamino-6-phenyl-5-[6-[1-[2-[(1,2,3,4-tetrahydro-9-acridinyl)amino]ethyl]-1H-1,2,3-triazol-4-yl]hexyl]-phenanthridinium (C42 H45 N8 +1, 661.9 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries).…

Component
TZ4
Formula
C42 H45 N8 +1
Class
ligand
Structures
12
PDB entries
6

Binding sites

TZ4 in 12 structures; the first of them:

  • 1Q84 · Crystal structure of the mouse acetylcholinesterase-TZ2PA6 anti complex · TZ4 A951 · binds TYR72, ASP74, GLY82, TRP86, GLY120, GLY121, TYR124, TYR133 and 18 more
  • 2XUF · Crystal structure of mache-Y337A-TZ2PA6 anti complex (1 mth) · TZ4 A1545 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 14 more
  • 2XUG · Crystal structure of mAChE-Y337A-TZ2PA6 anti complex (1 wk) · TZ4 A1545 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 13 more
  • 2XUH · Crystal structure of mache-Y337A-TZ2PA6 anti complex (10 mth) · TZ4 A1543 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 14 more
  • 2XUO · CRYSTAL STRUCTURE OF MACHE-Y337A mutant in complex with soaked TZ2PA6 ANTI inhibitor · TZ4 A1543 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 13 more
  • 2XUQ · CRYSTAL STRUCTURE OF the MACHE-Y337A mutant in complex with soaked TZ2PA6 ANTI-SYN… · TZ4 A1543 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 14 more
  • 1Q84 · Crystal structure of the mouse acetylcholinesterase-TZ2PA6 anti complex · TZ4 A951 · binds TYR72, ASP74, GLY82, TRP86, GLY120, GLY121, TYR124, TYR133 and 18 more
  • 2XUF · Crystal structure of mache-Y337A-TZ2PA6 anti complex (1 mth) · TZ4 A1545 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 14 more
  • 2XUG · Crystal structure of mache-Y337A-TZ2PA6 anti complex (1 wk) · TZ4 A1545 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 13 more
  • 2XUH · Crystal structure of mache-Y337A-TZ2PA6 anti complex (10 mth) · TZ4 A1543 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 14 more
  • 2XUO · Crystal structure of mache-Y337A mutant in complex with soaked TZ2PA6 anti inhibitor · TZ4 A1543 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 13 more
  • 2XUQ · Crystal structure of the mache-Y337A mutant in complex with soaked TZ2PA6 anti-syn… · TZ4 A1543 · binds TYR72, ASP74, LEU76, GLY82, THR83, TRP86, GLY120, GLY121 and 14 more

Residues it binds most

TYR 24, GLY 24, TRP 24, GLU 24, PHE 24, HIS 24, ASP 24, LEU 24, ALA 20, THR 20 (residue and the binding sites it lines).

Found with

  • P6G · Hexaethylene glycol
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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