UniProt P21695
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (P21695)
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (UniProt P21695), EC 1.1.1.8: 13 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 16 pockets. Binding sites, druggability and experiment against…
- UniProt
- P21695
- Protein
- Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
- EC
- 1.1.1.8
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 16 · 3 records with a druggable one
Structures
14 records of P21695 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WPQ | Ternary Complex Of Glycerol 3-phosphate Dehydrogenase 1 with NAD and dihydroxyactone | x-ray diffraction | A, B | — | — |
| 1WPQ | Ternary complex of glycerol 3-phosphate dehydrogenase 1 with NAD and dihydroxyactone | x-ray diffraction | A, B | — | — |
| 1X0V | Crystal Structure of Homo Sapien Glycerol-3-Phosphate Dehydrogenase 1 | x-ray diffraction | A, B | — | — |
| 1X0V | Crystal structure of homo sapien glycerol-3-phosphate dehydrogenase 1 | x-ray diffraction | A, B | — | — |
| 1X0X | Co-Structure of Homo Sapiens Glycerol-3-Phosphate Dehydrogenase 1 complex with NAD | x-ray diffraction | A | — | — |
| 1X0X | Co-structure of homo sapiens glycerol-3-phosphate dehydrogenase 1 complex with NAD | x-ray diffraction | A | — | — |
| 6E8Y | Unliganded human glycerol 3-phosphate dehydrogenase | x-ray diffraction | A, B | PO4, 3SY, K | — |
| 6E8Z | Binary complex of Human glycerol 3-phosphate dehydrogenase with NAD | x-ray diffraction | A, B | NAD, PO4, K | 3 (best 0.66) |
| 6E8Z | Binary complex of human glycerol 3-phosphate dehydrogenase with NAD | x-ray diffraction | A, B | NAD, PO4, K | — |
| 6E90 | Ternary complex of human glycerol 3-phosphate dehydrogenase | x-ray diffraction | A, B, C, D | NAD, 13P, CA, PO4 | 9 (best 0.77) |
| 6E90 | Ternary complex of human glycerol 3-phosphate dehydrogenase | x-ray diffraction | A, B, C, D | NAD, 13P, CA, PO4 | — |
| 6PYP | Binary Complex of Human Glycerol 3-Phosphate Dehydrogenase, R269A mutant | x-ray diffraction | A, B | NAD, PO4, 3SY, POP, K | 4 (best 0.60) |
| 6PYP | Binary complex of human glycerol 3-phosphate dehydrogenase, R269A mutant | x-ray diffraction | A, B | NAD, PO4, 3SY, POP, K | — |
| P21695 | AlphaFold monomer V2.0 prediction for glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic… | predicted | A | — | — |
Ligands
Experiment against prediction
- 6E90 chain A against the predicted model P21695: TM-score 0.99, RMSD 0.66 Å
- 6E90 chain A against the predicted model P21695: TM-score 0.99, RMSD 0.66 Å
- 6E90 chain B against the predicted model P21695: TM-score 0.99, RMSD 0.81 Å
- 6E90 chain B against the predicted model P21695: TM-score 0.99, RMSD 0.81 Å
- 1X0X chain A against the predicted model P21695: TM-score 0.98, RMSD 0.98 Å
- 1X0X chain A against the predicted model P21695: TM-score 0.98, RMSD 0.98 Å
- 1WPQ chain A against the predicted model P21695: TM-score 0.98, RMSD 1.02 Å
- 1WPQ chain A against the predicted model P21695: TM-score 0.98, RMSD 1.02 Å
- 1X0V chain B against the predicted model P21695: TM-score 0.98, RMSD 1.08 Å
- 1X0V chain B against the predicted model P21695: TM-score 0.98, RMSD 1.08 Å
Elsewhere
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