UniProt P15116
Cadherin-2 (P15116)
Cadherin-2 (UniProt P15116): 18 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P15116
- Protein
- Cadherin-2
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 28 · 4 records with a druggable one
Structures
19 records of P15116 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NCG | Structural basis of cell-cell adhesion by cadherins | x-ray diffraction | A | YB | 1 (best 0.37) |
| 1NCG | Structural basis of cell-cell adhesion by cadherins | x-ray diffraction | A | YB | 1 (best 0.37) |
| 1NCH | Structural basis of cell-cell adhesion by cadherins | x-ray diffraction | A, B | YB | 4 (best 0.74) |
| 1NCH | Structural basis of cell-cell adhesion by cadherins | x-ray diffraction | A, B | YB | 4 (best 0.74) |
| 1NCI | Structural basis of cell-cell adhesion by cadherins | x-ray diffraction | A, B | IUM | 1 (best 0.38) |
| 1NCI | Structural basis of cell-cell adhesion by cadherins | x-ray diffraction | A, B | IUM | 1 (best 0.38) |
| 1NCJ | N-cadherin, two-domain fragment | x-ray diffraction | A | CA, IUM | — |
| 1NCJ | N-cadherin, two-domain fragment | x-ray diffraction | A | CA, IUM | — |
| 1OP4 | Solution Structure of Neural Cadherin Prodomain | solution nmr | A | — | 1 (best 0.35) |
| 1OP4 | Solution structure of neural cadherin prodomain | solution nmr | A | — | 1 (best 0.35) |
| 2QVI | Crystal structure of N-cadherin domains EC12 | x-ray diffraction | A | CA | — |
| 2QVI | Crystal structure of N-cadherin domains EC12 | x-ray diffraction | A | CA | — |
| 3Q2W | Crystal structure of mouse N-cadherin ectodomain | x-ray diffraction | A | NAG, CA, MAN | 2 (best 0.44) |
| 3Q2W | Crystal structure of mouse N-cadherin ectodomain | x-ray diffraction | A | NAG, CA, MAN | 2 (best 0.44) |
| 4NUM | Crystal structure of mouse N-cadherin EC1-2 A78SI92M | x-ray diffraction | A, B, C, D | CA | 4 (best 0.62) |
| 4NUM | Crystal structure of mouse N-cadherin EC1-2 A78SI92M | x-ray diffraction | A, B, C, D | CA | 4 (best 0.62) |
| 4NUQ | Crystal structure of mouse N-cadherin EC1-2 W2F | x-ray diffraction | A | CA | 1 (best 0.33) |
| 4NUQ | Crystal structure of mouse N-cadherin EC1-2 W2F | x-ray diffraction | A | CA | 1 (best 0.33) |
| P15116 | AlphaFold monomer V2.0 prediction for cadherin-2 (P15116) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4NUQ chain A against the predicted model P15116: TM-score 0.99, RMSD 0.60 Å
- 4NUQ chain A against the predicted model P15116: TM-score 0.99, RMSD 0.60 Å
- 2QVI chain A against the predicted model P15116: TM-score 0.99, RMSD 0.61 Å
- 2QVI chain A against the predicted model P15116: TM-score 0.99, RMSD 0.61 Å
- 4NUM chain B against the predicted model P15116: TM-score 0.99, RMSD 0.68 Å
- 4NUM chain B against the predicted model P15116: TM-score 0.99, RMSD 0.68 Å
- 4NUM chain C against the predicted model P15116: TM-score 0.98, RMSD 0.81 Å
- 4NUM chain C against the predicted model P15116: TM-score 0.98, RMSD 0.81 Å
- 4NUM chain D against the predicted model P15116: TM-score 0.97, RMSD 0.90 Å
- 4NUM chain D against the predicted model P15116: TM-score 0.97, RMSD 0.90 Å
Elsewhere
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