MolNFT v1 · #15689 · protein

Structural basis of cell-cell adhesion by cadherins

1NCG · N-cadherin: “Structural basis of cell-cell adhesion by cadherins”. X-ray diffraction, 1 ligand (YB), 1 pocket (best druggability 0.37). MolNFT v1 #15689 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1NCG
Type: protein
Length: 99 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: N-cadherin
UniProt: P15116
Ligands: YB
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	N-cadherin	protein	99	5% helix, 39% strand	P15116

Ligands and binding sites

YB · Ytterbium (III) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.37	0.80	12	empty

Compared structures

1NCG · Structural basis of cell-cell adhesion by cadherins · the same entry in another collection · chain A against A, TM-score 1.00
P15116 · AlphaFold monomer V2.0 prediction for cadherin-2 (P15116) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15116
Elsewhere: RCSB PDB 1NCG · PDBe 1NCG · UniProt P15116

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.