UniProt P14324
Farnesyl pyrophosphate synthase (P14324)
Farnesyl pyrophosphate synthase (UniProt P14324), EC 2.5.1.1, 2.5.1.10: 165 experimental structures and 1 predicted model on GenesisL1, 20 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P14324
- Protein
- Farnesyl pyrophosphate synthase
- EC
- 2.5.1.1, 2.5.1.10
- Experimental structures
- 165
- Predicted models
- 1
- Ligands
- 20
- Pockets
- 7 · 6 records with a druggable one
Structures
166 records of P14324 in the MolNFT archive: 165 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YQ7 | Human farnesyl diphosphate synthase complexed with risedronate | x-ray diffraction | A | — | — |
| 1YQ7 | Human farnesyl diphosphate synthase complexed with risedronate | x-ray diffraction | A | — | — |
| 1YV5 | Human farnesyl diphosphate synthase complexed with Mg and risedronate | x-ray diffraction | A | — | — |
| 1YV5 | Human farnesyl diphosphate synthase complexed with mg and risedronate | x-ray diffraction | A | — | — |
| 1ZW5 | X-ray structure of Farnesyl diphosphate synthase protein | x-ray diffraction | A | — | — |
| 1ZW5 | X-ray structure of farnesyl diphosphate synthase protein | x-ray diffraction | A | — | — |
| 2F7M | Crystal Structure of Unliganded Human FPPS | x-ray diffraction | F | — | — |
| 2F7M | Crystal structure of unliganded human fpps | x-ray diffraction | F | — | — |
| 2F89 | Crystal structure of human FPPS in complex with pamidronate | x-ray diffraction | F | — | — |
| 2F89 | Crystal structure of human fpps in complex with pamidronate | x-ray diffraction | F | — | — |
| 2F8C | Crystal structure of FPPS in complex with Zoledronate | x-ray diffraction | F | — | — |
| 2F8C | Crystal structure of fpps in complex with zoledronate | x-ray diffraction | F | — | — |
| 2F8Z | Crystal structure of human FPPS in complex with zoledronate and isopentenyl diphosphate | x-ray diffraction | F | — | — |
| 2F8Z | Crystal structure of human fpps in complex with zoledronate and isopentenyl diphosphate | x-ray diffraction | F | — | — |
| 2F92 | Crystal structure of human FPPS in complex with alendronate | x-ray diffraction | F | — | — |
| 2F92 | Crystal structure of human fpps in complex with alendronate | x-ray diffraction | F | — | — |
| 2F94 | Crystal structure of human FPPS in complex with ibandronate | x-ray diffraction | F | — | — |
| 2F94 | Crystal structure of human fpps in complex with ibandronate | x-ray diffraction | F | — | — |
| 2F9K | Crystal structure of human FPPS in complex with Zoledronate and Zn2+ | x-ray diffraction | F | — | — |
| 2F9K | Crystal structure of human fpps in complex with zoledronate and ZN2+ | x-ray diffraction | F | — | — |
| 2OPM | Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461 | x-ray diffraction | A | — | — |
| 2OPM | Human farnesyl diphosphate synthase complexed with bisphosphonate bph- 461 | x-ray diffraction | A | — | — |
| 2OPN | Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527 | x-ray diffraction | A | — | — |
| 2OPN | Human farnesyl diphosphate synthase complexed with bisphosphonate bph- 527 | x-ray diffraction | A | — | — |
| 2QIS | Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate | x-ray diffraction | A | — | — |
| 2QIS | Crystal structure of human farnesyl pyrophosphate synthase T210S mutant bound to risedronate | x-ray diffraction | A | — | — |
| 2RAH | Human FDPS synthase in complex with novel inhibitor | x-ray diffraction | A | — | — |
| 2RAH | Human fdps synthase in complex with novel inhibitor | x-ray diffraction | A | — | — |
| 2VF6 | Human FDPS synthase in complex with minodronate | x-ray diffraction | A | — | — |
| 2VF6 | Human fdps synthase in complex with minodronate | x-ray diffraction | A | — | — |
| 3B7L | Human farnesyl diphosphate synthase complexed with MG and minodronate | x-ray diffraction | A | — | — |
| 3B7L | Human farnesyl diphosphate synthase complexed with mg and minodronate | x-ray diffraction | A | — | — |
| 3CP6 | Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and… | x-ray diffraction | A | — | — |
| 3CP6 | Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with mg and… | x-ray diffraction | A | — | — |
| 3N1V | Human FPPS COMPLEX WITH FBS_01 | x-ray diffraction | F | — | — |
| 3N1V | Human fpps complex with FBS_01 | x-ray diffraction | F | — | — |
| 3N1W | Human FPPS COMPLEX WITH FBS_02 | x-ray diffraction | F | — | — |
| 3N1W | Human fpps complex with FBS_02 | x-ray diffraction | F | — | — |
| 3N3L | Human FPPS complex with FBS_03 | x-ray diffraction | F | — | — |
| 3N3L | Human fpps complex with FBS_03 | x-ray diffraction | F | — | — |
| 3N45 | Human FPPS complex with FBS_04 and zoledronic acid/MG2+ | x-ray diffraction | F | — | — |
| 3N45 | Human fpps complex with FBS_04 and zoledronic ACID/MG2+ | x-ray diffraction | F | — | — |
| 3N46 | Human FPPS complex with NOV_980 and zoledronic acid/MG2+ | x-ray diffraction | F | — | — |
| 3N46 | Human fpps complex with NOV_980 and zoledronic ACID/MG2+ | x-ray diffraction | F | — | — |
| 3N49 | Human FPPS COMPLEX WITH NOV_292 | x-ray diffraction | F | — | — |
| 3N49 | Human fpps complex with NOV_292 | x-ray diffraction | F | — | — |
| 3N5H | Human fpps complex with NOV_304 | x-ray diffraction | F | — | — |
| 3N5H | Human fpps complex with NOV_304 | x-ray diffraction | F | — | — |
| 3N5J | Human fpps complex with NOV_311 | x-ray diffraction | F | — | — |
| 3N5J | Human fpps complex with NOV_311 | x-ray diffraction | F | — | — |
| 3N6K | Human FPPS complex with NOV_823 | x-ray diffraction | F | — | — |
| 3N6K | Human fpps complex with NOV_823 | x-ray diffraction | F | — | — |
| 3RYE | Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate | x-ray diffraction | A | — | — |
| 3RYE | Human fdps synthase in complex with a N-methyl pyridinum bisphosphonate | x-ray diffraction | A | — | — |
| 3S4J | Human FDPS Synthase in Complex with a Rigid Analog of Risedronate | x-ray diffraction | A | — | — |
| 3S4J | Human fdps synthase in complex with a rigid analog of risedronate | x-ray diffraction | A | — | — |
| 4DEM | Crystal structure of human FPPS in complex with YS_04_70 | x-ray diffraction | F | — | — |
| 4DEM | Crystal structure of human fpps in complex with YS_04_70 | x-ray diffraction | F | — | — |
| 4GA3 | Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1260 | x-ray diffraction | A | — | — |
| 4GA3 | Crystal structure of human farnesyl diphosphate synthase in complex with bph-1260 | x-ray diffraction | A | — | — |
106 records more on the page itself.
Ligands
- PO4 · Phosphate ion · in 14 records
- CL · Chloride ion · in 5 records
- MG · Magnesium ion · in 3 records
- SO4 · Sulfate ion · in 3 records
- T93 · [[(4-hexoxypyridin-2-yl)amino]-phosphono-methyl]phosphonic acid · in 2 records
- YL5 · [(1R)-2-(3-fluorophenyl)-1-{[6-(4-methylphenyl) thieno[2,3-d]pyrimidin-4-yl]amino}ethyl]phosphonic acid · in 2 records
- YL6 · [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl) ethyl]phosphonic acid · in 2 records
- 5A7 · {(E)-2-[6-(acetylamino)-8-(naphthalen-1-yl)quinolin-2-yl]ethenyl}phosphonic acid · in 1 record
- 5B9 · 2-(naphthalen-1-ylmethoxy)benzoic acid · in 1 record
- 5BJ · 4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid · in 1 record
- 5BK · 1H,1'H-4,4'-biindole-2-carboxylic acid · in 1 record
- 5BL · 8-(naphthalen-1-yl)-6-(1H-pyrrol-2-yl)quinoline-2-carboxylic acid · in 1 record
- 6O3 · {[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-5-yl]methyl}phosphonic acid · in 1 record
- FPP · Farnesyl diphosphate · in 1 record
- KF7 · [(1S)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid · in 1 record
- KFA · [(1R)-1-{[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid · in 1 record
- M2V · [(1R)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid · in 1 record
- M2Y · [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-phenylethyl]phosphonic acid · in 1 record
- YF7 · [(1S)-1-{[6-(3-chloro-4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}-2-(3-fluorophenyl) ethyl]phosphonic acid · in 1 record
- YL4 · [(R)-(2,3-dihydro-1-benzofuran-5-yl){[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino}methyl]phosphonic acid · in 1 record
Experiment against prediction
- 4N9U chain A against the predicted model P14324: TM-score 1.00, RMSD 0.30 Å
- 4N9U chain A against the predicted model P14324: TM-score 1.00, RMSD 0.30 Å
- 2QIS chain A against the predicted model P14324: TM-score 1.00, RMSD 0.34 Å
- 2QIS chain A against the predicted model P14324: TM-score 1.00, RMSD 0.34 Å
- 3S4J chain A against the predicted model P14324: TM-score 1.00, RMSD 0.35 Å
- 3S4J chain A against the predicted model P14324: TM-score 1.00, RMSD 0.35 Å
- 4N1Z chain F against the predicted model P14324: TM-score 1.00, RMSD 0.35 Å
- 4N1Z chain F against the predicted model P14324: TM-score 1.00, RMSD 0.35 Å
- 4NKF chain A against the predicted model P14324: TM-score 1.00, RMSD 0.36 Å
- 4NKF chain A against the predicted model P14324: TM-score 1.00, RMSD 0.36 Å
Elsewhere
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